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Biomedical subjects

M Strober

Publications and source records attributed to M Strober.

66 records · Page 4Linked to original sources
PubMed1981

Phenomenology and subtypes of major depressive disorder in adolescence.

The authors systematically evaluated the prevalence and reliabilities of a large set of depressive symptoms and subtypes of major depressive disorder in 40 hospitalized adolescents, aged 12-17. Results indicated that the phenomenology of depressive illness in this age group is distinguished by descriptive features akin to traditional clinical formulations. Psychotic, retarded and endogenous subtypes were documented, although they are less prevalent than in adult depressives. Overall, the reliabilities of symptom and subtype ratings were found to be very satisfactory. Results were discussed with respect to current theoretical conceptions of juvenile affective illness and directions for further research.

Adolescent↗
PubMed1981

The relation of personality characteristics to body image disturbances in juvenile anorexia nervosa: a multivariate analysis.

The relationship between Minnesota Multiphasic Personality Inventory (MMPI) factors and two separate measures of body image-estimation of body size and subjective report of distorted bodily experiences-was investigated using multivariate analyses in adolescent females with anorexia nervosa. A canonical correlational analysis of these data indicated the presence of two orthogonal dimensions defining the relation between personality and body image scores. In the first canonical variate, size overestimation and subjective body image distortion were both associated with MMPI scales reflecting somatization, anxiety, and atypical thinking; in the second variate, size overestimation alone was found to be associated with introversion and depression, while subjective body image distortion aligned with somatization and atypical thinking. The results suggest that different measures of body image disturbance are associated with different personality characteristics. Results are discussed in terms of the importance of personality factors in the pathogenesis of body image disturbances in anorexia nervosa.

Adolescent↗
PubMed1979

The structuring of interpersonal relations in schizophrenic adolescents: a decentering analysis of Thematic Apperception Test stories.

This study tested the hypothesis that schizophrenics employ more developmentally immature levels of decentering in their structuring of interpersonal relations. A 9-point scale of interpersonal decentering, developed originally by Feffer, was applied to Thematic Appercetion Test stories produced by schizophrenic adolescents and a control group of psychiatrically disturbed patients equivalent in age and intellectual functioning. Results provided convincing support for the hypothesis tested and suggest the theoretical utility of viewing interpersonal deficit in schizophrenia from a cognitive-developmental perspective.

Adolescent↗
PubMed1979

Body image disturbance in anorexia nervosa during the acute and recuperative phase.

Perception of body size, subjective experience of body image distortions and differentiation of body concept in the human figure drawing were assessed in adolescent anorexia nervosa patients and controls shortly after hospital admission, and again 6 months later during the recuperative phase. Size estimation was not found to be a distinguishing variable, as both groups exhibited overestimation tendencies of comparable magnitude at both time periods. By contrast, experiences denoting estrangement from the body, insensitivity to body sensations, and weakness of body boundaries were more prevalent in anorexics, and persisted at high levels after frank symptoms of weight and eating disorder had subsided. Anorexics were also shown to depict the human figure with less differentiation relative to controls. Within the anorexic sample the presence of vomiting was linked to greater subjective experience of body image distortion, and such phenomena appear to be a more enduring feature in this subgroup. Overall, the results were viewed as lending support to the argument that defects in body image formation render the anorexic vulnerable to their manifest pathology, which is itself activated by maturational conflicts unique to adolescence.

Acute Disease↗
PubMed1978

Medicaid madness.

Explore the source record for details and available documents.

Ethics, Medical↗
PubMed1978

Affective disorder in adolescence: issues in misdiagnosis.

This case report describes a young adolescent female with bipolar manic-depressive illness, (MDI), whose behavioral symptomatology was originally attributed to non-affective forms of psychopathology. We review her entire clinical course to date and elucidate several factors that may account for diagnostic error.

Adolescent↗
PubMedDate not supplied

A family study of bipolar I disorder in adolescence. Early onset of symptoms linked to increased familial loading and lithium resistance.

Lifetime rates of psychiatric illness were compared in relatives of adolescent probands with bipolar I disorder and in relatives of age-matched schizophrenic controls. Familial aggregation of major affective disorders was observed in bipolar probands, the rate of bipolar I disorder greatly exceeding that reported in relatives of adult bipolar probands. Adolescent probands with childhood onset of psychiatric disturbance were distinguished from probands who had no premorbid childhood psychiatric abnormality in two ways: (1) significantly increased aggregation of bipolar I disorder in first-degree relatives; and (2) poorer antimanic response to lithium carbonate. These data underscore important heterogeneity in adolescent-onset bipolar disorder.

Adolescent↗
PubMedDate not supplied

Effects of intravenous and oral dexamethasone on selected lymphocyte subpopulations in normal subjects.

Our studies describe the effects of 1 mg oral (PO) and intravenous (IV) administration of dexamethasone (DEX) on certain subpopulations of circulating lymphocytes in normal subjects. We compared the outcomes of PO and IV DEX administration because of individual differences in gastro-intestinal absorption of DEX and the issue of noncompliance in patients undergoing the dexamethasone suppression test (DST). Both routes of DEX administration were equally effective in suppressing plasma cortisol levels below 5 micrograms/dl, the customary criterion level. Both routes of DEX administration also significantly decreased the percent and absolute number of CD4+ cells, the CD4+/CD8+ ratio, and the percent and absolute number of virgin, but not of memory, CD4+ cells.

Administration, Oral↗
PubMedDate not supplied

Personality factors in anorexia nervosa.

Evidence concerning the role of personality factors in the etiopathogenesis of anorexia nervosa is reviewed. Although data are sparse and limited by a variety of methodologic problems, certain traits, such as poor self-esteem, compliancy and perfectionism, and impaired autonomy have been described with impressive consistency, suggesting they are part of a continuum of causative factors giving rise to anorexia nervosa. Furthermore, other personality characteristics appear to modify the clinical expression, course, and prognosis of this condition.

Anorexia Nervosa↗