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Biomedical subjects

M Strobel

Publications and source records attributed to M Strobel.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Natural resistance to mycobacteria: antimicrobial activity and reactive oxygen intermediate releasing functions of murine macrophages.

After infection with Mycobacterium lepraemurium or with M. bovis strain BCG (bacillus Calmette-Guérin), splenic macrophages from mice naturally resistant (NR) to these pathogens (C3H and A/J) spontaneously produced H2O2, whereas splenic macrophages from naturally susceptible (NS) mice (C57BL/6 and Swiss) did not. None of them produced superoxide anion O2-. In addition, NR macrophages had higher levels of superoxide dismutase (SOD) than did NS macrophages. In vivo treatments thought to enhance H2O2 metabolism (phorbol myristate acetate, SOD, Zymosan) decreased M. lepraemurium survival, whereas treatment with diethyl-dithiocarbamate, a potent inhibitor of SOD, had the converse effect. These results favour the hypothesis of a link between natural resistance to BCG (and M. lepraemurium) and H2O2 metabolism, with higher producers being naturally resistant.

Animals↗
PubMedDate not supplied

[Enchondroma of the hand].

Enchondromata are the most frequent benign tumours of the bones of the hand. From 1973 to 1990 77 patients were treated at the trauma- and hand surgery department of the Westfälische Wilhelms-University in Münster because of a histologically confirmed enchondroma. Those 52 patients (32 female, 20 male, average age 32 years), who were operated on until 1986 were reviewed. After an average history of 16 months the diagnosis was made most often because of a painful swelling. In 15% a spontaneous fracture was seen and in 17% the enchondroma was diagnosed by chance. The enchondroma was merely exstirpated or in other cases the defect was filled with a bone graft. The follow-up with a maximal time of 14 years postoperatively yielded in 81.6% an excellent and good result. A 5.7% (3 pat.) recurrence rate was observed and was attributed to an incomplete resection of the underlying pathology. Follow up X-rays are therefore recommended.

Adolescent↗
PubMedDate not supplied

[Leprosy in Guadeloupe (French West Indies): declining disease, increasing diagnosis delay].

INTRODUCTION: Endemic for nearly three centuries, leprosy is declining in Guadeloupe: its prevalence has decreased by 75 p. 100 over the last decade. Because it has become rare, it may well be overlooked. PATIENTS AND METHODS: Retrospective study of all the new cases of leprosy diagnosed in Guadeloupe from May 1996 to May 2001. RESULTS: In 10 cases of the 41 reported in this study, diagnosis had been delayed by more than 6 months. Nine of these 10 cases presented with classical clinical signs. The mean delay before diagnosis in these 10 cases was of 22 months (range: 7-36 months); the mean number of consultations with a physician before the final diagnosis was of 3.2 (range: 2-8). The mean age at the time of diagnosis in patients in whom diagnosis was delayed was significantly greater than those in whom diagnosis was confirmed rapidly (55 vs. 37 years). DISCUSSION: In Guadeloupe, one patient out of 4 presenting with leprosy is diagnosed with a delay of more than 6 months, despite a classical clinical presentation. This is deleterious to the patients and health economics. The patients in whom diagnosis was delayed were older. This epidemiological tendency appears inherent to this form of "residual leprosy". The present rareness of the disease is responsible for a lack of knowledge of the disease by the physicians through lack of experience. This phenomenon is also observed for syphilis and measles. There is a real risk of underestimation or erroneous diagnosis.

Adolescent↗
PubMedDate not supplied

[Psychosocial guidance of nursing home personnel by group therapy. Basic considerations and initial experience].

Support groups for those professional caregivers who work in homes for the aged are seldom. Focussing on occupational stressors in this profession and the burnout research as a conceptual framework, a support group is introduced. To sustain the social competence and the coping skills of the caregivers are the basic aims of this group. Based on role taking and psychodrama as intervention techniques, outcomes from this group are discussed. Recommendations for future groups as a support system for caregivers in homes for the aged are derived.

Adaptation, Psychological↗
PubMedDate not supplied

[Acquired immunodepression syndrome in Guadeloupe].

Guadeloupe is a small Caribbean Island, with racial intermixed population. AIDS prevalence is four time higher than in France. Socio-economical and sanitary levels are similar to those of developed countries. On the other hand, AIDS has epidemiological patterns close to those of under developed countries. This contradiction is discussed. Epidemiological, clinical and psycho-sociological aspects are reviewed.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Ecology of a focus of cutaneous leishmaniasis in the Thies region (Senegal, West Africa). 2. Epidemiological and clinical peculiarities of the human disease].

During their epidemiological survey of a cutaneous leishmaniasis focus, the authors study the epidemiological and clinical aspects of 60 proven human cases observed in the studied area (Thies region). The disease can occur at any age but is more frequently seen in the pre-adolescent (10-15 years), adolescent (15-20 years) and adult (20-40 years) age classes. During the year, 76.5% of the lesions appear between july and the end of november. The spontaneous evolution of the disease seems to have a one year duration. Less than 10 lesions are observed in the majority of the cases (91.5%). The lesions are mainly located on upper and/or lower limbs and are generally of humid ulcerated type, often covered by a deep scar; a lymphatic nodular dissemination from a lesion occurs in 25% of the cases.

Adolescent↗
PubMedDate not supplied

[Leprosy tests: diagnostic problems (apropos of 2 cases)].

Two cases of reactional leprosy leading to wrong diagnosis are reported. The first one concerns a reversal reaction predominantly neuritic, initially taken for polyarthritis. The second one concerns an erythema nodosum leprosum with extensive cutaneous necrosis (Lucio's phenomenon or ulcerative lazarine leprosy). Main aspects and mechanisms of leprosy reactional states are reviewed. It is emphasized that errors or delays in diagnosis are often caused by failing to recognize cutaneous or neuritic symptoms.

Adult↗
PubMedDate not supplied

[Red grain mycetomas (A. pelletieri). Apropos of 20 new cases in Dakar].

20 cases of mycetoma A. pelletieri coming from Sénégal are reported. This series confirms the peculiar localisation, extension and severity of this type of mycetoma: 14 cases located outside the foot (buttock, perineum, scrotum, inguinocrural area, abdominal and chest wall); frequency of lymph node involvement; importance of superficial extension; surgical possibilities overreached in more than 1/3 of the cases. Effectiveness of sulfa-methoxy-trimethoprime in the medical management is outlined.

Actinomycetales Infections↗