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Biomedical subjects

M Stone

Publications and source records attributed to M Stone.

At least 163 records · Page 9Linked to original sources
PubMed1978

Conditioning prostheses viewed from the standpoint of speech adaptation.

Subjects who had adapted to experimental alveolar-palatal prostheses for 2 weeks were able to speak naturally with them after a lapse of a month. Physiologic data on jaw motions and tongue-palate contacts during speech showed a rapid return to compensatory articulatory patterns. A single subject who had previously adapted to an experimental prosthesis over a period of a week made the same type of compensatory jaw adjustments when speaking with the prosthesis again 1 year later.

Acrylic Resins↗
PubMed1978

The use of Pro-Banthine to induce gastrointestinal hypotonia.

Immediate and satisfactory gastrointestinal hypotonia was induced in 48 patients with 5--10 mg of intravenous Pro-Banthine during radiographic examination; side-effects were minimal. If given intravenously in small doses, Pro-Banthine is a satisfactory alternative when glucagon is contraindicated or not available.

Digestive System↗
PubMed1978

Developments of computer-based estimation of pA2 values and associated analysis.

The standard statistical-computing package GLIM is used to analyze data from agonist-antagonist studies for the estimation of the dissociation constant of the antagonist. The method follows the general approach of D.R. Waud (Analysis of dose-response curves. In Methods in Pharmacology, vol. 3, Smooth Muscle, ed. by E.E. Daniel and M. Paton, Plenum Press, New York, 1975) in employing an iterative nonlinear least-squares curve-fitting procedure. However, it differs in two important respects: 1) it is interactive; and 2) it allows linear adjustments for covariates and experimental design variables. This paper develops develops an alternative useful formulation of departure from simple competitivity and also a graphical display called a "Clark plot" showing how the spacings of the dose-response lines fit the theory of simple competitive antagonism. This plot provides an alternative to the popular Schild plot for which, of necessity, the zero antagonist (control) dose-response line is heavily used both in the experimental design and in the analysis associated with it.

Computers↗
PubMed1977

Beta-human chorionic gonadotrophin and carcino-embryonic antigen in the management of ovarian carcinoma.

Measurements of HCG and carcino-embryonic antigen (CEA) were made in 26 patients with ovarian cancer to evaluate these substances as tumour markers; 13-4 per cent of 194 CEA estimations and 14-6 per cent of 144 HCG estimations were abnormal. CEA values were abnormal in 9 out of 26 patients and HCG values in 13 out of 26 patients. The implications of these findings particularly the presence of HCG are discussed.

Adenocarcinoma↗
PubMed1977

Growth and development of gastrocnemius muscle in S 5B/PL and Osborne-Mendel rats overfed during nursing.

Three techniques for overfeeding rat pups were used from birth to 24 days of age to assess their effect on growth and development in an obesity susceptible (OM) and an obesity resistant (S 5B/P1) strain of rat. These included: (1) Feeding a semi-purified high fat rather than low fat diet to the dams (alters the energy content of milk); (2) Raising pups in litters of 3 rather than 6; and (3) Force feeding of milk in lieu of any force feeding. In OM rats there was no difference in lean body mass (excludes heart, liver and kidney) (LBM) gastrocnemius muscle weights, cell number and protein content of muscle. Body weights and gastrocnemius muscle triglycerides were significantly higher in OM rats fed the high fat diet than in those fed the low fat diet. S 5B/P1 (S) rats treated in the same manner as OM, showed no significant differences in body weight, LBM, gastrocnemius muscle weight or content of DNA, protein or triglycerides. Protein and DNA for 100 g fresh gastrocnemius muscle were similar for the two strains even though the muscle was 1 1/2 times heavier in OM than in S rats. Muscle triglycerides were higher in OM than in S rats.

Animals↗
PubMed1976

Relationship of oral contraception to development of trophoblastic tumour after evacuation of a hydatidiform mole.

The need for chemotherapy for trophoblastic tumour after evacuation of a hydatidiform mole was found to be significantly increased in patients taking oral contraceptives before normal human chorionic gonadotrophin (HCG) values were obtained. Oral contraception was also found to delay the fall in HDG excretion in patients not requiring treatment with cytotoxic drugs.

Chorionic Gonadotropin↗
PubMed1976

Papillary necrosis in kidney transplant patients.

Of 158 renal transplant recipients, 75 underwent excretory urography at some point during a six-year period, 24 hours to 7 years after transplantation. In 11 patients, renal papillary necrosis (RPN) was found. RPN was associated in 9 patients with one or more disease entities known to be the etiologic factor to RPN in nontransplanted kidneys. In 2 patients, previous rejection episodes were the probable case for RPN. Renal papillary necrosis, a rather late complication with renal allograft, was demonstrated in this population on an average of 28.1 months after transplantation.

Adult↗