Search PubMed⌕ Search

Biomedical subjects

M Stolte

Publications and source records attributed to M Stolte.

At least 433 records · Page 24Linked to original sources
PubMed1990

Differences in Helicobacter pylori associated gastritis in the antrum and body of the stomach.

In 1,265 patients with Helicobacter pylori (HP)-associated gastritis, the degree of HP colonisation correlated in a highly significant manner with the degree and the activity of gastritis in the antrum and body. The degree of HP colonisation is identical in both body and antrum in 49.3%, the antrum being more markedly colonised in 38.7% and the body in 12.0%. In comparison, the degree and activity of gastritis is more pronounced in the antrum in 71.3% and 72.5%, respectively, the corresponding figures for the body being only 3.4% and 7.3%, respectively. The degree of HP colonisation, and also the degree and activity of gastritis, are not age-related. In the body, the degree of colonisation by HP increases with advancing age. In parallel to this, there is also a statistically significant increase in the degree and activity of gastritis in the body. In comparison with the antrum, however, the inflammatory reaction in the body is less pronounced than in the antrum, even with increasing age. The different milieu in the antrum vis-a-vis the body, with changes in acid secretion behaviour is discussed as a possible cause of these differences.

Adult↗
PubMed1989

[Lambliasis: a cause of malabsorption and diarrhea?].

Multiple biopsies from the lower duodenum were obtained during endoscopy of 171 patients with dyspepsia, diarrhoea and/or suspected malabsorption. Histological evidence of lambliasis was obtained in six (3.5%). Antibiotic treatment with metronidazole, 250 mg two or three times daily for seven to 11 days (which had to be repeated in two cases), improved symptoms in four. In most of the patients "functional upper-abdominal symptoms" had been diagnosed after extensive examinations. In case of unclear upper-abdominal symptoms, chronic or chronic-recurrent diarrhoea and/or malabsorption lambliasis should be considered and histological examination of the duodenal mucosa undertaken.

Adult↗
PubMed1989

Lymphoid follicles in antral mucosa: immune response to Campylobacter pylori?

The prevalence of lymphoid follicles in endoscopic biopsy specimens from normal antral mucosa (n = 220), mucosa with reflux gastritis (n = 104), and in cases with Campylobacter pylori-associated gastritis (n = 2544) was studied. In the latter group whether there were associations between degree and activity of gastritis and the prevalence of lymphoid follicles and between the occurrence of lymphoid follicles and the presence of intestinal metaplasia in the antrum were investigated. In cases with normal mucosa and in those with reflux gastritis lymphoid follicles were not detected, but mucosal lymphoid follicles were found in 1297 (54%) of the cases with C pylori-associated gastritis. The prevalence of lymphoid follicles in the antral mucosa depended on the degree and activity of the gastritis and also correlated with the presence of intestinal metaplasia. The development of lymphoid follicles in the mucosa of the antrum probably represents, primarily, an immune response to the colonisation of the mucosa by C pylori.

Adolescent↗
PubMed1989

Topographic association between active gastritis and Campylobacter pylori colonisation.

One thousand biopsy specimens obtained from 10 sites in the stomachs of 50 patients were examined for the presence of active chronic gastritis and Campylobacter pylori. All 32 patients with active chronic gastritis at 234 out of 320 sites were positive for C pylori: 227 showed colonisation with C pylori by the Warthin-Starry stain; and 222 were positive by culture. C pylori was not found in 18 patients with inactive chronic gastritis or histologically normal mucosa. The area of C pylori colonisation was larger than the area of active chronic gastritis in 289 positive specimens on culture and 261 on staining, respectively, suggesting that C pylori colonisation may precede the development of active chronic gastritis. It is concluded that patchy distribution of active chronic gastritis and C pylori colonisation must be considered, particularly in serology or breath test studies where the histological examination serves as a reference. Furthermore, it may have important implications for the follow up of patients after antibacterial treatment. The topographic and specific association of C pylori and active chronic gastritis provides further evidence for the pathogenic role of C pylori in active chronic gastritis.

Adult↗
PubMed1989

Gastric glandular cysts--investigations into their genesis and relationship to colorectal epithelial tumors.

One thousand five hundred cases presenting with glandular cysts of the gastric mucosa (Elster's polyps) (64.2 per cent women, 38.8 men) were investigated. The average age of 57.1 +/- 14.5 years militates against the possibility of these polyps being Hamartomas. In 41 out of 100 cases submitted to follow-up gastroscopies, these Elster's polyps were either reduced in number and sitze, or else had newly formed in previously unremarkable mucosa--which is further argument against the hamartoma hypothesis and in favour of a functional-secretory genesis. The results of 596 cases submitted to examinations of colorectal epithelial tumours (24.8 per cent in the overall group, and 35.6 per cent in those patients submitted to examination of the entire colon by means of colonoscopy and/or colon contrast enema). In 21 patients with adenomatosis coli (including 11 patients with Gardner's syndrome), in addition to Elster's polyps, a higher incidence of adenomas in the upper gastrointestinal tract was also observed (57.1%), in 5 cases taking the form of initial tubular adenomas in the apex of Elster's polyps. After surgical treatment, some of the patients (28.6%) revealed a reduction in the number of polyps in the stomach. On the basis to these results, a thorough diagnostic work-up of the colon in patients with Elster's polyps is recommended.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenomatous Polyposis Coli↗
PubMed1989

[The solid-cystic pancreas tumor].

Solid-cystic pancreas neoplasia is a rare condition mostly observed in young adults and women. We report three cases of this rare tumor. In all three instances the patients were young, slender women. The tumors were removed by total resection of the pancreas. In two cases these tumors were very large. In two cases we also observed criteria which could indicate that these tumors were malignant: the tumors had infiltrated the adjacent spleen and adjoining lymphnode or displayed a destroyed capsula. Until now, such infiltrative or malignant qualities have not been reported. That such criteria can be conclusively evaluated as an indication of malignancy, remains, however, unclear.

Adenoma, Islet Cell↗
PubMed1989

[Campylobacter pylori in heterotopic gastric mucosa in Meckel's diverticulum].

We report a case of Meckel's diverticulum with heterotopic gastric body mucosa, active gastritis in the heterotopic mucosa and dense colonisation by Campylobacter pylori. This case, together with four identical cases recently reported, and a further case with C. pylori colonisation of heterotopic gastric mucosa in the rectum, shows that C. pylori obviously traverses the length of the Gl tract--a fact that makes the faecal-oral route of infection probable.

Appendectomy↗
PubMed1989

[Endoscopic biopsy diagnosis of malignant lymphoma of the stomach and early stomach lymphoma].

From 1978 to 1988 a malignant lymphoma of the stomach was diagnosed endoscopic-bioptically in 47 patients. In 41 patients it was a primary gastric lymphoma, in 6 a generalized lymphoma. In 20 cases an advanced gastric lymphoma was present which was diagnosed endoscopic-bioptically without problems. In 27 cases, however, lymphomas showed polymorphous lesions which did not look tumorous. In such cases the lymphomas were found in an early stage and bioptic verification was difficult. On an average three bioptic series were needed for histological proof. In 16 lymphomas of this group the malignant infiltration was limited to mucosa/submucosa on operative resection specimens ("early gastric lymphomas") The endoscopic appearance of these early lymphomas was: thickening mucosa-folds (2 cases), extended areas of "regenerative mucosa" and granular pattern (6 cases), mainly multiple irregular ulcerations (8 cases). The above mentioned endoscopic findings are strongly suspected for an early gastric lymphoma and should be clarified by, if needed repeated, bioptic series.

Adult↗
PubMed1988

[The prognosis of carcinoid tumors of the stomach].

Follow-up examinations were carried out in 55 patients with small carcinoid tumours in the stomach (diameter 0.5-1.7 cm). For the most part, the tumours were located within the body and fundus of the stomach, with only 3 being found in the antrum. Thirty-five of the 55 patients (63.6%) had multiple gastric carcinoids, while in 46 patients (83.6%) concomitant chronic atrophic gastritis was also present. Eight patients were treated surgically, while 47 patients were merely kept under endoscopic/bioptic surveillance. In 34 out of 40 patients in whom the diagnosis had been established more than 6 months previously (longest observation period 13 years), follow-up findings were available (7 surgical patients, 27 non-operated patients). The patients submitted to surgery (average follow-up period 3.5 years) are alive and free of complaints between 1 and 9 years post-op; no metastases have occurred, but a recurrent tumour has developed in a single patient. Among the 27 non-operated patients (average follow-up period 3.6 years), 3 have died of diseases unrelated to the carcinoid tumours, in none of the other patients has there been any change in the findings. On the basis of these results it is concluded that, in carcinoid tumours of the stomach with a diameter of less than 1.0 cm, surgical treatment is not absolutely necessary, and that, in comparison with the risks represented by surgical mortality and post operative morbidity, regular endoscopic/bioptic follow-up can be considered to be adequate.

Adult↗
PubMed1987

[Are stomach polyps an indicator of colonic carcinoma and colonic polyps an indicator of stomach carcinoma?].

Over a period of six years a total of 407 patients with polyps of the gastrointestinal tract were examined by gastroscopy and coloscopy and the findings analysed retrospectively. Among patients with colon polyps 10.5% were found also to have polypoid gastric lesions, among those with adenoma of the colon the prevalence was 11.7%. Only 2.4% of simultaneously diagnosed gastric lesions were found to be malignant or premalignant, a figure similar to the population average. But in patients with more than ten polyps of the colon both the prevalence of polypoid gastric changes and the significance of polyps with respect to precancerous lesions were clearly increased. On the other hand, in patients with epithelial polyps and/or glandular cysts colon polyps were found in 45%, in 42% with precancerous changes (adenoma). Thus patients with epithelial gastric polyps and glandular cysts probably constitute a group with a real additional risk of colon carcinoma. Regular coloscopy will thus reveal precancerous changes (adenoma) in the colon of 42% of such patients; coloscopic polypectomy will be an effective prophylactic measure against carcinoma of the colon.

Adenomatous Polyposis Coli↗
PubMed1987

Somatostatinoma of Vater's papilla and of the minor papilla.

Two cases of somatostatinomas of the major and minor papilla are reported. The tumors were characterized by solid trabecular and tubular arrangements of tumor cells and in one case by the presence of microvilli and psammoma bodies. The tumor cells contain many amine precursor uptake and dicarboxylation (APUD)-granules with a diameter of 300 to 500 nm and low electron density. Immunoperoxidase stain showed intense staining only for somatostatin and low density of neuron-specific enolase. Those tumors either resulted from pluripotent endocrine cells or from D-cells of the mucosa or glands of the papilla.

APUD Cells↗