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Biomedical subjects

M Stewart

Publications and source records attributed to M Stewart.

At least 487 records · Page 27Linked to original sources
PubMed1978

Impaired granulocyte adherence. A reversible defect in host defense in patients with poorly controlled diabetes.

When the ability of granulocytes from 10 poorly controlled diabetic patients with fasting hyperglycemia and no evidence of ketoacidosis (mean fasting glucose 293 +/- 20 mg. per 100 ml.; mean +/- S.E.M.) to adhere to a nylon fiber column was assessed, the number of adherent granulocytes from whole blood was only 53 +/- 6 per cent of the values observed in controls. After antidiabetic treatment for one to two weeks and lowering of fasting glucose levels (mean 198 +/- 29 mg. per 100 ml.), adherence improved significantly (p less than 0.01) in the diabetics; however, their values were still subnormal (diabetic 74 per cent +/- 8 of control; p less than 0.02). Adherence values before and after treatment correlated with the fasting glucose level (r = 0.88, p less than 0.001). These findings suggest that, in addition to previously reported abnormalities in migration and the ingestion and killing of bacteria, granulocyte adherence may also be impaired in poorly controlled diabetic patients. This functional abnormality correlates directly with the fasting glucose and is reversed by insulin treatment. A defect of this type may compromise the normal inflammatory response in some diabetics and impair their capacity to resist infection.

Blood Glucose↗
PubMed1978

Attitudes and patterns of practice: a comparison of graduates of a residency program in family medicine and controls.

Two groups of graduates of the University of Western Ontario Faculty of Medicine were compared. The study group had satisfactorily completed a two-year residency program in family medicine at the University, commencing at graduation from medical school; the controls had completed a one-year internship after graduation, but had not pursued specific residency training in family medicine. Both groups were engaged in family practice in Ontario at the time of the study. As predicted, the groups differed in their attitudes; the graduates were more satisfied with practice than the controls and placed more importance on emotional factors in illness. Anticipated differences in patterns of care provided were also found. Family medicine graduates of conducted proportionately more noninstitutional care. The findings were not generalized beyond the one program. The advantages and limitations of program evaluation through studies of graduates are discussed.

Attitude of Health Personnel↗
PubMed1977

A controlled study of siblings of hyperactive children.

A controlled study of siblings of hyperactive boys resulted in the following findings. The hyperactive child syndrome is more common among brothers of hyperactive children than among brothers of controls (26 per cent vs. 9 per cent). Both probands and their brothers presented with more symptoms of depression-anxiety than controls. The probands, but not their sibs, presented with more antisocial symptoms than controls. Although differences in intelligence and achievement scores were found between probands, their sibs, and controls, both intelligence level and academic achievement were within normal limits in all groups.

Achievement↗
PubMed1976

Muscle structure and function--an explanation.

The structure of vertebrate skeletal muscle is reviewed. The mechanism of muscular contraction and its control is then discussed from the point of view of molecular structure. Contraction takes place by a sliding filament mechanism produced by cross-bridges which form between thick and thin filaments. Control is exercised by tropomyosin and troponin. When the calcium concentration is low, these proteins interfere with the formation of cross-bridges and prevent contraction, but when the calcium concentration is increased, they no longer interfere and contraction proceeds.

Actins↗