Clinico-pathological conference. Case 16, part 1.
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Biomedical subjects
Publications and source records attributed to M Stern.
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Burn units that treat relatively few patients need a technique by which they may make valid comparisons between their results and mortality curves derived from larger series of data. While the technique described is consistent with the probit mode, the most widely accepted statistical model for studying burn mortality, it aboids the cumbersome calculations associated with probit analysis.
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No one method of burn treatment has been shown to give results clearly superior to any other, although results of therapy in units using different methods do vary significantly. Probit analysis can be used to see whether or not a burn unit meets the standard of care of representative units.
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After initial neurosurgical treatment, 40 patients who regained consciousness 1 to 90 days after major cerebral trauma, were admitted for rehabilitation. Six months after their injury they were assessed in terms of: 1) Locomotor function, 2) Intellectual performance, 3) Communication disorder, and 4) behaviour disturbances. The usefulness of these parameters as prognostic factors in rehabilitation is discussed. Eight patients without significant disabilities in all 4 parameters returned to normal life. Patients who showed locomotor, communicative and behaviour impairment but no gross intellectual deficits, were considered capable of being retrained. The poorest prospects for social and vocational rehabilitation were found in 15 patients with cognitive defects.
Pyrogallol and N1-(d,1-seryl)-N2-(2,3,4-trihydroxy-benzyl)-hydrazine (RO-4-4602), two inhibitors of catechol-O-methyl-transferase, produce exophthalmus in mice and rats. This exophthalmus can be suppressed by local application of guanethidine.
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