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Biomedical subjects

M Stefan

Publications and source records attributed to M Stefan.

89 records · Page 5Linked to original sources
PubMedDate not supplied

Ultrastructural peculiarities of intercellular junctions in bronchopulmonary carcinomas.

Six bronchopulmonary carcinomas of various histological types (macrocellular, epidermoid) were electronmicroscopically studied on bronchial biopsy samples. The scarcity of intercellular junctions was observed in all of them, especially in carcinoma types or zones (i.e. of epidermoid carcinoma) less differentiated. Close and gap junctions, zonulae adherentes and maculae adherentes dominated the structure of poorly differentiated carcinomas, while the differentiated types also presented frequent desmosomes. Also the reduction of intercellular junctions frequency was accompanied by their ultrastructural aberrations. The ultrastructural changes observed were correlated to the capacity for invasion of investigated carcinomas without reducing this basic property of cancer cells to the former.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Liver enzymatic induction after repeated or prolonged stress.

Changes in liver tyrosine aminotransferase induction were measured in mice after repeated or prolonged stressing. In the repeated chloroform stress variant the first impulse determines the amplitude of TAT induction; the second stress can only produce superinduction if repeated 40 minutes after the onset of the first one. In the prolonged irradiation stress variant the response was dependent on both the dose rate and duration of irradiation.

Animals↗
PubMedDate not supplied

Biochemical and cytogenetical study of the mycoplasmal antigen and of the cyclophosphamide action in mammalians, in vivo. The action of some immunomodulatory antioxidants.

It was proved spectrophotometrically that Mycoplasma agalactiae antigen inoculated in vivo in sheep modifies the corresponding erythrocyte lysates reactivity toward methylene blue and neutral red and induces several types of chromosomal rearrangements. The treatment in vivo of sheep with an original preparation obtained from the Phaseolus vulgaris pods restores the erythrocyte lysates reactivity toward the two redox dyes and reduces the chromosomal abnormalities frequency induced by the mycoplasmal antigen. It was also demonstrated by optical and electronical microscopy that the Smise line mouse meiocytes exhibit chromosomal abnormalities induced by the cyclophosphamide treatment in vivo. In the case of concomitant treatment with the cyclophosphamide and C vitamin the same frequency of abnormalities was recorded as in the simple treatment with the drug.

Adjuvants, Immunologic↗