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Biomedical subjects

M Starlinger

Publications and source records attributed to M Starlinger.

97 records · Page 6Linked to original sources

[The proximal gastric vagotomy in the treatment of uncomplicated duodenal ulcer (author's transl)].

Of 97 patients, who had a PGV since July 1971, 86 were checked intraoperatively on completeness of vagotomy with various methods, including Kongo-red-staining, pH-electrode and Burge-test. On theoretical grounds, the Burge-test combined with pH-measurement seems the most reliable procedure. In 14 cases an incomplete Vagotomy could such be avoided. 72 patients, who met the critiria of more than 6 months follow-up, were graded according to VISICK with 89% good results (I, II) and 11% VISICK III, IV. Two Patients needed reoperation, one with recurrent ulcer. Our results confirm the good impression we had initially, regarding the low postoperative morbidity, effective reduction of acidity and recurrence rate, but longterm follow-up studies are still required to form a final judgement.

Drainage↗

[Postoperative enterocutaneous fistulae of the small gut (author's transl)].

Postoperative enterocutaneous fistulae are fortunately rate (1 : 1000), but they carry a mortality of about 50%. The authors analyse the development and treatment of fistulae in 30 patients. This depends on whether the cause of the fistula is connected with an anastomosis or not, on a variety of pathologic-anatomical criteria and in particular on the amount of fluid lost daily. If this loss is less than 500 ml/24 h the fistula can be regarded as relatively benign and in all probability conservative treatment alone will succeed. Fistulae with a fluid loss of more than 500 ml/24 h have a worse prognosis and require a combined conservative and surgical therapy. The key to this problem is the optimal time for surgical intervention, it lies around the 4th week. In case an early operation is necessary one must be prepared for an enterostomy or by-pass procedure.

Drainage↗

LaparoLith. A new instrument for stone fragmentation in laparoscopic cholecystectomy.

Laparoscopic cholecystectomy can be performed with incisions of a maximum diameter of 10 mm. The removal of a stone-filled gallbladder at the end of an operation via the 10-mm port needs often-extensive tissue-consuming manipulations for stone removal or minilaparotomy. Stone fragmentation can be achieved by mechanical crushing and by ultrasound-, electrohydraulic-, and tunable dye laser lithotripsy. The clinical employment of the LaparoLith (Baxter Healthcare Corporation), an instrument which allows mechanical fragmentation of stones inside the gallbladder, is presented here. We have used the LaparoLith in nine patients and have been successful in stone fragmentation in seven of these. The LaparoLith seems to be helpful in laparoscopic cholecystectomy, preventing extension of the subnavel incision.

Cholecystectomy, Laparoscopic↗

Effect of the protease inhibitor aprotinin on renal hemodynamics in the pig.

Aprotinin, the serine protease inhibitor that also inhibits glandular (urinary) kallikrein, or vehicle was infused into the aorta above the renal arteries of anesthetized pigs. Renal hemodynamic and functional parameters were followed over time and during hemorrhagic hypotension. Both renal cortical blood flow and glomerular filtration rate were maintained in vehicle-treated animals at mean arterial pressures as low as 70 mm Hg. As long as renal cortical blood flow and glomerular filtration rate were maintained during the progressive hypotension, urinary excretion rate of kallikrein (as defined by kinin-generating activity) was increased. In contrast, all aprotinin-treated animals had a decreased excretion rate, and the renal cortical blood flow declined with the mean arterial pressure during hemorrhage. The pattern of glomerular filtration rate and plasma renin activity was comparable in both aprotinin-treated and vehicle-treated hemorrhaged animals. Our findings suggest that the endogenous renal kallikrein-kinin system is required for functional renal vasodilatation to maintain renal cortical blood flow during hemorrhage and is therefore directly or indirectly responsible for adjustment of preglomerular resistance.

Analysis of Variance↗