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Biomedical subjects

M Speich

Publications and source records attributed to M Speich.

35 records · Page 2Linked to original sources
PubMed1987

Se, Zn, Mg, Ca, K, cholesterol, and creatine kinase concentrations in men during the 12 days after an acute myocardial infarction.

We determined concentrations of selenium, zinc, magnesium, calcium, potassium, total and high-density lipoprotein cholesterol, and total creatine kinase (EC 2.7.3.2) in plasma (P) and (or) erythrocytes (E) of 32 men at the time of hospital admission for acute myocardial infarction and then on subsequent days 2, 3, 6, 10, and 12. During these 12 days, only P-selenium and high-density lipoprotein cholesterol concentrations remained unchanged. For the other variables, individual comparison of means indicated the dates of significant changes in concentration (p less than 0.05).

Adult↗
PubMed1985

[Magnesium, calcium, zinc, potassium, total and HDL cholesterol and total creatine kinase in 37 cases of instable angina: a correlation study].

Plasma and erythrocyte magnesium (P-Mg, E-Mg), zinc (P-Zn, E-Zn) and potassium (P-K, E-K), plasma calcium (P-Ca), HDL-cholesterol and total cholesterol and total creatine kinase (TCK) were determined in 37 cases (26 men, 11 women) of unstable angina pectoris (UAP) on the first day of hospitalization. The same variables, except P-K and TCK, were measured in 58 male and 53 female reference subjects. The methods of measurement were emission spectrometry for K, atomic absorption spectrometry for Mg, Ca and Zn, and the R CK NAC-activated Merckotest for TCK. According to the normality of distributions, statistical analysis of results was performed either by parametric or nonparametric tests. Multiple (R), simple (r) and Spearman (rs) correlation coefficients were calculated, and only significant correlations (p less than or equal to 0.05) were accepted. There was no significant R for UAP patients. For UAP men, r was negative and significant between P-Mg and E-K, but positive between P-Ca and P-Zn, as for reference subjects; and rs was negative and significant between P-Zn and TCK. For UAP women, only rs was positive and significant, between P-Mg and TCK. In the UAP population, contrary to the reference population, there were no significant differences relative to sex. In comparison with reference men, UAP men presented a significant (p less than 0.005) increase in E-Mg and significant (p less than 0.001) decreases in P-Ca and P-Zn.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Low lead doses and atherogenic diet in rabbits: biochemical results in blood.

Changes in concentrations of blood lead, cholesterol, triacylglycerols, GOT and GPT enzymes, phosphorus, proteins, plasma calcium and magnesium, and erythrocyte magnesium were studied for 25 weeks in 4 groups of 6 rabbits each receiving different diets: I (controls), II (water with 9.66 mumol/l of lead), III (atherogenic) and IV (atherogenic + 9.66 mumol/l of lead). Differences observed, with respect to the diets, for lead, cholesterol, enzymes, proteins and erythrocyte magnesium were evident from the 42nd day on. Low lead doses raised the levels of cholesterol and triacylglycerols in group II, whereas triacylglycerols were lower in the plasma of group IV in comparison with group III and were accumulated in the aorta. The elevation of enzymes in groups III and IV indicated heart and liver dysfunctions. There was a significant drop in erythrocyte magnesium in groups III and IV, which was especially marked in the latter group, with an interaction between the two diets.

Alanine Transaminase↗
PubMed1983

Concentrations of lead, magnesium, calcium, zinc and cadmium in twenty rabbit tissues after exposure to low lead doses and atherogenic diet.

Four groups of 6 rabbits were subjected to the following diets for 25 weeks: I (controls), II (water with 9.66 mumol/l of lead), III (atherogenic) and IV (atherogenic + 9.66 mumol/l of lead). Lead, magnesium, calcium, zinc and cadmium were then analyzed in 20 dry tissues. At the level of the arteries, veins and skin a tendency was observed toward increased lead concentration in rabbits of groups II and IV, elevated calcium levels in groups III and IV (a tenfold increase of calcium in the aortas), and a higher concentration of cadmium in animals of group II. There was a significant reduction in lead and magnesium concentrations in the liver of animals in groups III and IV because of fibrosis and overabundance of fatty liver cells. The lead level in the liver of animals in group II had slightly increased. Lead concentrations were higher in the kidneys and spleen in groups II and IV. Cadmium levels were significantly lower in the liver, kidneys, adrenal glands and spleen of animals in groups III and IV, whereas in group II they were particularly increased in the liver and kidneys. Very little significant interaction between the two diets was noted. Rabbits in groups III and IV showed notable histopathological alterations in aorta, carotid and femoral arteries, left ventricle and liver. Extrapolation from rabbit to man would be inadvisable.

Animals↗
PubMed1982

Concentrations of lead, cadmium, and zinc in human heart muscle and aorta after acute myocardial infarction.

Zinc, lead, and cadmium were measured in the myocardium (left and right ventricles) and aorta of 14 women and 12 men who had died from acute myocardial infarction (MI), and of 12 control women and 15 control men who had died of acute trauma. Mineral content of the necrotic areas of the MI patients was also determined. There was little significant correlation with age, and sex could not be shown to influence the cation concentrations. Significantly larger concentrations of lead and cadmium were observed in the right ventricle of women controls. In the four populations, significantly higher zinc concentrations were found in the left ventricle. Lead and cadmium levels in aortas were consistently higher than those in left ventricles, whereas zinc levels were always lower. The lead content in the ventricles and aorta of MI victims was consistently greater than for control subjects, though the difference was not significant. However, in the necrotic area, a significant decrease in zinc concentration was noted. These results are discussed and compared with other results published previously. It is concluded that studies in this area must be continued as there are still many uncertainties.

Adolescent↗
PubMed1981

Reference values for ionized, complexed, and protein-bound plasma magnesium in men and women.

Of the three magnesium fractions in plasma, free ionized magnesium (Mg2+) has the greatest biological activity. Accordingly, information concerning this form in plasma is of cardinal importance to investigations in biometry and human pathology. For this reason, we developed an indirect assay for ionized magnesium in which Mg2+ is determined as the difference between ultrafiltrable magnesium, as measured in plasma water after ultracentrifugation, and complexed magnesium, as obtained after fixation of the ionized and protein-bound magnesium on Amberlite IR-120(H) cation-exchange resin. All magnesium assays were performed by atomic absorption spectrometry. We used this methodology to compare ionized, complexed, and protein-bound plasma magnesium in 34 normal men and 12 normal women. Sex-related differences between the values for these fractions were not significant. Interesting preliminary results for cases of myocardial infarction prompt us to continue our investigations concerning these three states of plasma magnesium in cardiac pathology.

Adult↗
PubMed1980

Concentrations of magnesium, calcium, potassium, and sodium in human heart muscle after acute myocardial infarction.

Atomic absorption spectrometry was used to measure magnesium, calcium, and sodium, and emission spectrometry to measure potassium, in myocardium (left and right ventricles) of 26 control subjects who died of acute trauma. Results were expressed in mumol/g of proteins. Mg/Ca and K/Na ratios were also determined. The same measurements were made in 24 patients who died from acute myocardial infarction. Samples were also taken from the necrotic area. Mg/Ca and K/Na ratios were significantly higher in the left ventricle of both populations, thus providing evidence of anatomical and physiological differences between the two ventricles. As a result of cytolysis and anoxia, the Mg/Ca ratio was very significantly inverted, and the K/Na ratio very significantly smaller, for samples from the necrotic area. In these clinical conditions arrhythmias could certainly be considered likely, and there is reason to believe that magnesium depletion may be a cause of arrhythmias.

Adolescent↗
PubMed1977

[Study of magnesium level in myocardium and aorta tissues from subjects free of ishemic necrosis (author's transl)].

Before carrying out a study on the levels of magnesium in the myocardium and the aorta in subjects who had died of coronary thrombosis, we determined the reference levels of magnesium in the right and left ventricles and in the aorta of sixteen normal subjects. The samples were homogenized and digested with nitric acid/hydrochloric acid mixture before the measurement itself was made; this was carried out by atomic absorption spectrophotometry. The magnesium values are expressed in microng/g of wet tissue, in mg/g of tissular proteins, in mg/ of total lipids in the aortic wall. The differences between the concentrations of proteins or magnesium in the left and right ventricles are significant magnesium in the left and right ventricles are significant (P less than 0,001). They probably derive from anatomic and physiological differences. We have found a correlation which is significantly positive between magnesium level and protein level in the ventricle. In the aorta, the results for proteins, lipids and magnesium are extremely dispersed because of the heterogeneous nature of biochemical composition of this tissue according to age and area which it has been taken from.

Aorta↗
PubMedDate not supplied

[Circadian rhythms in man. Their incidence in endocrinology (author's transl)].

The authors, after a classification of the main biological rhythms, mention the parameters of the circadian rhythm deduced by mathematical analysis of so-called "Cosinor". They then devote their study to the main hormones, the secretion of which depends on circadian periodicity. They emphasize the effect that their biorhythm has on the value of plasma concentrations depending on the time of sampling. They suggest standardisation of this time in drawing up international norms.

Adolescent↗