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Biomedical subjects

M Spatz

Publications and source records attributed to M Spatz.

At least 127 records · Page 7Linked to original sources
PubMed1979

Histochemical investigation of the Mongolian gerbil's brain during unilateral ischemia.

The ischemic effect on cerebral enzymes and glycogen content was histochemically evaluated in mongolian gerbils subjected to unilateral common carotid artery occlusion for various periods of time from 1/2 to 9 h. In early stages (up to 2 h), the only enzyme affected was the phosphorylase which revealed a decreased activity. Thereafter, the observed changes inclusive of glycogen and other enzymes such as the dehydrogenase, nonspecific acid and alkaline phosphatases, leucine aminopeptidase and thiamine pyrophosphatase progressed proportionally to the duration of ischemia. There was an overall inverse appearance of histochemically demonstrated enzymatic disturbances between the severely damaged ischemic regions and its marginal zones; the former revealing a conspicuous decrease and/or loss of enzymatic activities while the latter showing an increase of the same enzymes. Correlating the various ischemic responses of the intracellular organelles it appears that the changes in the lysosomes and Golgi apparatus occurred slower than those of mitochondria.

Acid Phosphatase↗
PubMed1978

Transient ischemic alteration of synaptosomal neutral amino acid uptake.

The effect of cerebral ischemia and postischemia on the synaptosomal uptake of some neutral amino acids was determined in mongolian gerbils at various periods of time. A transiently increased uptake of 3H isoleucine, 14C cycloleucine and 3H phenylalanine in the synaptosomes was found after 3 min of bilateral common carotid occlusion which returned to normal at 30 min of reestablished cerebral blood circulation.

Amino Acids↗
PubMed1978

Uptake of radiolabeled glucose analogues by organotypic cerebellar cultures.

Permeability of brain cells to radiolabeled glucose analogues with sucrose or inulin or L-glucose was studied in the living, intact state of the organotypic cerebellar cultures. In vitro uptake of 3H 3-O-methyl D-glucose and 3H 2-deoxy-D-glucose exhibited saturation kinetics with increasing substrate concentrations. Each of the labeled sugars uptake could be self-inhibited in the presence of unlabeled (cold) substrate and cross-inhibited with cold glucose or xylose or phlorizin present in the incubating medium. The uptake was Na-independent and stereo-specific for D-form.

Animals↗