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Biomedical subjects

M Spadaro

Publications and source records attributed to M Spadaro.

70 records · Page 4Linked to original sources
PubMedDate not supplied

Recent results in ataxia research.

Five families with late onset spinocerebellar ataxia (SCA) were studied. A high association was found between the disease and HLA. A stronger association results with a marker called D6S89. Clinical data of 26 patients and neuropathological study in two are reported. The clinical phenotypes of other HLA-linked SCA kindreds shows differences when comparison is made. The Authors suggest that the phenotype might appear more homogeneous if disease duration is taken into account.

Adult↗
PubMedDate not supplied

[Clinical study of two families with late-onset autosomal dominant spinal-cerebellar ataxia linked with HLA. Preliminary results].

Two families with autosomal dominant spinocerebellar ataxia (SCA) of late onset were studied. These families originate in the same small rural area in a Southern Italian region (Calabria). We report the clinical study of 23 patients in different stages of the disease and neuropathological study in one patient. Linkage studies provided strong evidence for linkage of the SCA locus to the HLA loci (SCA1) in the subjects of these families. Our study allows to outline the clinical features of HLA linked SCA in order to trace a pattern of SCA1 phenotype thus making easier the identification of SCA1 heterozygotes in an early clinical stage.

Adolescent↗
PubMedDate not supplied

Reduction of circulating suppressor inducer T lymphocytes in the exacerbation phase of remitting-relapse multiple sclerosis.

We studied peripheral blood mononuclear cells (PBMC) from 34 multiple sclerosis (MS) patients: 8 had chronic progressive (CP) and 26 with a relapsing-remitting (RR) course. PBMC were tested with a panel of monoclonal antibodies (MoAbs) including anti-CD3, CD4, CD8, CD25 reagents. In addition, the suppressor inducer lymphocyte subset was investigated by using two color staining with anti-CD4 and G1-15 and/or anti-CD4 and anti-Leu-8 MoaAbs. A significant decrease of the suppressor inducer subset was found in the exacerbation phase of the RR form. Furthermore, a significant decrease of CD8+ (suppressor/cytotoxic) cells was shown in the remission phase of the RR group. Finally, CD25+ lymphocytes were significantly increased in both phases of RR form.

Adult↗
PubMedDate not supplied

[Hemicrania-epilepsy syndrome: clinical contribution and pathogenetic interpretation].

6 patients suffering from migraine and consciousness disturbances occurring together in a significant chronologic association were selected retrospectively. Clinical, radiologic and electroencephalographic data are reported; the hypothesis of a common pathogenesis of the two syndromes is discussed by means of the "neural" theory of migraine and the results of cerebral blood flow studies in migrainous subjects. In addition, the therapeutic effectiveness of the pharmacologic association between calcium-antagonists and antiepileptic drugs in some patients is remarked.

Adolescent↗
PubMedDate not supplied

Preliminary reports on a therapeutical trial in multiple sclerosis.

A therapeutic trial with azathioprine and steroids has been carried out on a group of definite MS subjects. Such pharmacologic association was suggested by many observations pointing out the possibility of balancing the adverse effects of azathioprine by steroid administration. The therapeutic protocol included an alternate administration of azathioprine 2 mg/Kg/die for 15 consecutive days, followed by triamcinolone 40 mg IM in a single dose during the following 15 days. The patient population was composed of 34 subjects, 7 of which showed a RR course, 15 a RP form and 12 a CP course. Our results showed that this treatment appeared particularly useful in RP forms; it could also be indicated in CP forms, at the beginning of chronic progression.

Adult↗
PubMedDate not supplied

Non-clinical tests for the diagnosis of multiple sclerosis.

Liquoral, Neurophysiological and Nuclear Imaging data were investigated in 29 patients suffering from Definite (11 cases), Probable (11 cases) and Possible (7 cases) Multiple Sclerosis (MS). The most sensitive tests were: Visual Evoked Potentials (VEPs), altered in 75% of patients, Motor Evoked Potentials (MEPs), abnormal in 75%, Nuclear Magnetic Resonance Imaging (MRI) in 72.4%. Somatosensory Evoked Potentials (SEPs) were altered in 69.2% in PN-SEPs and in 53.6% in MN-SEPs, whilst Brainstem Evoked Potentials (BAEPs) were altered in 30.8% of cases. The results suggest that patients with suspected forms of MS should be submitted, as routine diagnostic protocol, to a battery of EPs, including as a first choice VEPs, MEPs and PN-SEPs. MRI should be performed to confirm a diagnosis not supported by EP data, or for a comprehensive localization of the demyelinating plaques.

Adolescent↗
PubMedDate not supplied

[New proposals for the treatment of multiple sclerosis. Preliminary study].

The authors carried out therapeutic preliminary trial on 8 Multiple Sclerosis patients traited by Azathioprine and corticosteroids in alternated administration during a period of 8-24 months. Treatment was efficacious in all examined subjects and tolerance was very good. The authors discuss upon the use of long-term immunosoppressive therapy in the different clinic types of multiple sclerosis.

Adult↗
PubMedDate not supplied

[CNV and psychiatry].

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Contingent Negative Variation↗
PubMedDate not supplied

[Hemicrania comitata. Critical review and clinical case reports].

The AA. examined 24 subjects suffering from classic or common migraine and 42 subjects with complicated migraine. In 6 cases of complicated migraine, radiologic investigations (cerebral CT scan or scintigraphy) showed ischemic lesions. The AA. discuss their results, on the basis of the most recent acquisitions concerning the pathogenetic mechanisms involved in the complicated migraine; particularly, they dwell upon "the platelet hypothesis".

Adolescent↗