Glycuronic acid and glycuronamide detoxicating activity.
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Biomedical subjects
Publications and source records attributed to M Soscia.
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The Author points up a review on the argument accordingly to the most recent literatur. Particularly are treated the status of meningococcal vaccines anti-A, C and Y groups (their preparations and trends in Field-trials), and the status of proteic vaccines anti-B. In the second part the most important substances in chemio-antibiotic prophylaxis are considered (rifampin, minocyclin, sulphadiazine, TMP, etc.) accordingly to their efficacy, safety and side-effects. The status of the perspectives on the control of the desease is discussed at the end.
The immunizing capability of a new anticholera vaccine (choleric anatoxin + vibrios Ogawa and Inaba) was tested on a group of 113 subjects. The vaccination was carried out with two inoculations of the vaccine, administered a month apart. Testings were taken before the vaccination, before the second inoculation and 10 to 14 days after the vaccination was completed. The determination of the vibriocide antibodies was made following the test-tube method described by Verwey and al., and the research of the antitoxic antibodies following Craig's method, using a live rabbit. Eighty two per cent of the subjects vaccinated had antitoxic antibodies with a varying strength of from 10 to greater than 320 A.U. In all those subjects treated who had previously been vaccinated at the time of the cholera epidemic with traditional vaccine, the geometric average of strength in vibriocide antibodies had increased from 2,810 to 14,700.
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A subset of peripheral T cells, whose physiological function is little known, expresses a distinct CD3-associated receptor composed of gamma and delta chains. We used two monoclonal antibodies to characterize the TcR gamma/delta lymphocytes (TcR delta 1+) and their fraction (TcS delta 1+) in peripheral blood and cerebrospinal fluid of patients affected by AIDS dementia complex (ADC). Thirty patients with ADC and a control group of twenty individuals with other non-inflammatory neurological diseases (OND) were recruited. Our results demonstrate that the TcR gamma/delta cells were also present in cerebrospinal fluid of ADC patients, but we did not find any statistical difference between the two groups.
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