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Biomedical subjects

M Sorin

Publications and source records attributed to M Sorin.

32 records · Page 2Linked to original sources
PubMed1976

[Isovaleric acidemia. Study and treatment in 3 brothers].

The cases of 3 sibs presenting with isovaleric acidemia are reported. The first infant died when he was 9 day-old. The two others appear to have benefited from a controlled leucine diet which was introduced from the first days on of life. The clinical symptomatology, highly typical of the disease, is described. Diagnosis was not assessed on amino-acids chromatography but on the chromatography of volatile fatty acids. The mode of treatment is described: peritoneal dialysis, with the object of rounding a crucial cape, and overall controlled leucine diet, but supplemented by essential amino-acids.

Amino Acid Metabolism, Inborn Errors↗
PubMed1974

[Inflammatory rheumatism in immunologic deficiencies].

The authors give a general review of rheumatic manifestations associated with immunodeficiency in children with reference to 7 personal observations. The review demonstrates the high frequency of this association, the variable clinical picture in one, a few, or many joints, the prolonged, relatively mild evolution that is never deforming or ankylosing, the existence of frequent auto-immune and rheumatic manifestations in families, and the usual but variable effectiveness of gammaglobulins. The possibility of immunodeficiency should be considered in cases of mono-, oligo-, and polyarthritis. The results of humoral and cellular immunological studies demonstrated a low level of immunoglobulins, the presence of nonfunctional B cells, and the presence of T cells that were probably qualitatively modified. A physiopathological interpretation is suggested.

Adolescent↗
PubMedDate not supplied

[Plasma concentrations of ornidazole in newborn infants and infants after iterative administration].

Ornidazole was administered for ten days to twelve hospitalized neonates at the same daily dose of 20 mg/kg either by one or two IV infusions. Minimum steady-state concentrations measured between the 4th and 10th day ranged from 7.8 to 17.3 (mean = 11.8 +/- 3.2 mg/l) for one daily infusion and from 10.9 to 26.6 (mean = 20.5 +/- 6 mg/l) for two infusions. These minimum concentrations were all above the minimum inhibitory concentration for the most clinically significant anaerobic bacteria. So the single daily administration of ornidazole at the dose of 20 mg/kg is sufficient to obtain therapeutic efficiency.

Bacterial Infections↗
PubMedDate not supplied

[Two viruses].

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Animals↗