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Biomedical subjects

M Sood

Publications and source records attributed to M Sood.

At least 37 records · Page 2Linked to original sources
PubMed1999

Left ventricular diastolic function in congenital myotonic dystrophy.

OBJECTIVE: Examination of left ventricular function and conduction abnormalities in myotonic dystrophy. DESIGN: Twelve patients (median age, 13.7 years) with myotonic dystrophy had detailed electrocardiography and echocardiography performed. Echocardiographic parameters were compared with body surface area (BSA) matched median normal values. RESULTS: Fractional shortening was slightly reduced (by 28-29%) in three patients and three patients had mild mitral valve prolapse. Diastolic function was abnormal; isovolumic relaxation time (IVRT) and duration of early filling were prolonged compared with control values (median IVRT, 74 v 61 ms). Peak E velocity was increased (median, 0.82 v 0.78 m/s) but atrial phase filling was normal. Heart rate was reduced (median, 68 v 81 beats/min). Conduction abnormalities were common but showed no clear relations with diastolic abnormalities. CONCLUSIONS: Young patients with myotonic dystrophy have myocardial diastolic dysfunction as well as abnormal electrophysiology. The prognostic implications of such abnormalities require further study.

Adolescent↗
PubMed1998

The use of human glutathione S-transferase A1 in the detection of cystic fibrosis liver disease.

OBJECTIVE: To determine the value of serum human glutathione S-transferase A1 (hGST A1) in the detection of cystic fibrosis liver disease (CFLD). METHODS: Sixty-three children (aged 0.5-16 years) with cystic fibrosis (CF) were screened prospectively for evidence of hepatobiliary abnormalities between February 1993 and February 1996. Comparison was made between clinical examination, abdominal ultrasonic scan, measurement of conventional liver enzymes (LFTs) and serum hGST A1 concentration in the detection of hepatobiliary abnormalities in children with CF. RESULTS: The 5-95% concentration of serum hGST A1 was 1.7-4.27 micrograms L-1 for the control group. The hGST A1 levels in the CF patients were significantly higher than in the non-CF group. Thirty-eight (60%) children had detectable hepatobiliary abnormalities. Ultrasound scanning detected the highest number of abnormalities (41%), followed by hGST A1 (30%). The presence of clinical liver disease was found in 19% of the children. The estimated sensitivities of detecting CFLD by clinical method, ultrasound scan, serum hGST A1, and LFTs would be 32%, 68%, 50% and 16%, respectively. CONCLUSIONS: Serum hGST A1 measurement increases the sensitivity of detecting hepatic abnormalities when included with clinical and ultrasound evaluation although, in some cases with advanced liver disease, serum hGST A1 may be normal. Conventional liver enzyme tests add little information in the detection of CF liver disease.

Adolescent↗
PubMed1997

Nonunion of uterine incision: a rare cause of secondary postpartum haemorrhage: a report of 2 cases.

Secondary postpartum haemorrhage after Caesarean section due to non-union of the uterine incision is an unusual complication. Two women who had had lower segment Caesarean section for placenta praevia presented after 2 and 3 weeks respectively with shock due to massive postpartum haemorrhage. The uterine scars had not healed in both of these women who were managed by emergency subtotal hysterectomy.

Adult↗
PubMed1997

Role of hysteroscopy in infertile women.

The diagnostic accuracy and therapeutic value of hysteroscopy were evaluated in 32 infertile women aged 21-35 years who underwent the procedure as part of their infertility evaluation. In 19 cases (59.4%) visually recognisable abnormalities were detected on hysteroscopy. These included intra-uterine adhesion (25%), submucous fibroid (9.4%), endometrial atrophy (9.4%), uterine septum (6.1%) and muellerian fusion defect (6.1%). The results of hysterosalpingography corresponded with hysteroscopy in 56.2% cases with a false positive of 30.7% for hysterosalpingography over hysteroscopy, and a false negative of 52.6%. Adhesion, fibroid and uterine septum accurately diagnosed were treated under hysteroscopic visualisation in the same sitting.

Adult↗
PubMed1997

Patterns of various modes of delivery in relation to presence of different risk factors in term pregnant mothers--a case-control study.

A case-control study, was carried out, which aimed to determine whether a relation exists between risk factors present in mother and the mode of delivery i.e., outcome. Cases were those mothers who had one or more risk factors present during pregnancy (namely, short stature, malpresentation, antepartum haemorrhage, pre-eclamptic toxaemia/eclampsia, anaemia-haemoglobin less than 10 g/dl, twins, bad obstetric history, prolonged pregnancy, history of previous caesarean section and instrumental delivery, pregnancy associated with general diseases, prolonged difficult labour and RH-iso-immunisation). Controls were those mothers who did not have any of the above mentioned risk factors. Total of 250 cases and 250 controls were taken. Results showed that surgical and instrumental deliveries were strongly associated with presence of risk factors (odd's ratio: 5.94; attributable risks: 72%). Out of risk factors among cases, most common indication of caesarean section, was previous caesarean section followed by malpresentation, prolonged difficult labour and short statured mothers in descending order.

Case-Control Studies↗
PubMed1995

Towards a safer motherhood.

One hundred cases each, in induced and spontaneous labour, were analysed to compare which group could achieve safer motherhood. It was observed that induced group with controlled labour has many maternal and foetal advantages like undisturbed domestic arrangements, avoidance of fatigue of patients and her relations, short duration of labour and minimal exposure to stress of labour, lower incidence of caesarean section and minimised perinatal morbidity and mortality.

Case-Control Studies↗
PubMed1994

Changing trends in maternal mortality over a decade.

OBJECTIVES: To study the change in trend in maternal mortality over the last decade and to find out specific causes of death. METHOD: A retrospective study was carried out at Lady Harding Medical College, New Delhi, to analyze the causes of maternal deaths. The admission ledgers of patients admitted over two 3-year periods (1979-1981 and 1989-1991) were studied to ascertain the total number of maternal deaths and the specific causes of death. RESULTS: One hundred fifty-eight deaths occurred during 1979-1981 and 149 deaths during 1989-1991. During the same period there were 23,098 and 37,763 total births, respectively, the overall maternal mortality rate thus significantly declining from 684/100,000 total births in 1979-1981 to 394/100,000 total births in 1989-1991. Sepsis followed by hemorrhage and hepatitis were the leading causes of maternal deaths over the decade. CONCLUSION: Health education and availability of health services, largely at a community level, would contribute to reducing the incidence of preventable causes of maternal deaths such as sepsis and hemorrhage.

Birth Rate↗
PubMed1994

Role of screening tests for gestational carbohydrate intolerance.

A variety of tests are available to screen gestational diabetes mellitus but there is disagreement about the value of these tests in screening it. One hundred-pregnant patients were selected at random for sequential gestational carbohydrate intolerance test (GCIT) with the purpose of identifying gestational diabetes mellitus (GDM) at its earliest. Patients with values of GCIT above 120 mg% were advised to undergo glucose tolerance test (GTT). GCIT at random is a great strain on hospital resources. But GCIT can identify the patients who need a GTT for diagnosing GDM. In many cases of abnormal GCIT, GTT may be normal.

Adult↗
PubMed1992

Taurodontism and pyramidal molars.

The present study was conducted to investigate the occurrence of taurodontism and pyramidal molars in Goa children, hitherto considered rare in Indians. Radiographs of 300 children of 9 to 13 years were evaluated. The criteria of Keene (1966) was used to designate taurodonts. Ten children showed taurodontism: involving mandibular second molars in eight cases, maxillary first molars in three cases; and pyramidal molars in three cases, four cases showed associated findings. Hypodontia of one to fourteen teeth was observed in all four cases. In addition one case showed thinning of maxillary central incisors, rotation of lateral incisors, impacted supernumerary and a canine and polydactyly of hands and feet. The condition does not appear rare in this population group.

Adolescent↗
PubMed1990

Perinatal mortality and morbidity in caesarean section.

The study was conducted on 350 babies born by caesarean section. There were 29 perinatal deaths among 350 births giving a gross perinatal mortality rate of 8.3 per 1000 live births. Corrected perinatal mortality rate was 7.1%. The stillbirth rate was 2%. It was high for cases of abruptio placentae, transverse lie and cord prolapse. Septicaemia was the commonest cause of perinatal death followed by asphyxia and prematurity. Birth weight played an important role in the survival of babies. There was no foetal loss among babies in weight group of 3501-4000 g. Perinatal morbidity was mainly due to asphyxia, septicaemia, prematurity and cord infection.

Birth Weight↗