Search PubMed⌕ Search

Biomedical subjects

M Sonobe

Publications and source records attributed to M Sonobe.

At least 55 records · Page 3Linked to original sources
PubMed1988

A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats.

A new prostaglandin E1 analogue (TFC-612) was orally given to streptozocin-diabetic rats for 4 weeks after the induction of diabetes and its effects on motor nerve conduction velocity were studied. The compound significantly prevented a decrease of the velocity but did not reverse abnormal sorbitol and myo-inositol contents of the sciatic nerve. The results suggest that TFC-612 has a potent effect on diabetic nerve dysfunction via other mechanism than the correction of sorbitol and myo-inositol metabolisms and could be a potential compound for therapy of diabetic polyneuropathy.

Alprostadil↗
PubMed1988

Evaluation of dead cases of ruptured intracranial aneurysms with special reference to a comparison between patients with early operations and unoperated cases.

The authors have analysed dead cases of ruptured intracranial aneurysms. This analysis included 270 patients with ruptured intracranial aneurysms, admitted to Mito National Hospital over an 8 yr period. Of the 98 patients who had surgery within 48 h after SAH, 17 cases died (mortality rate 17.3%); 7 deaths were due to massive haemorrhage, 5 due to vasospasm and 5 to other causes. Analysis of the causes of death in the non-surgical group (62 cases) disclosed that massive haemorrhage was the most common (29 cases), followed by rerupture after admission (14 cases), vasospasm (7 cases) and miscellaneous cases (5 cases). The possibility of improving the mortality rate in the early surgical group and the non-surgical group is discussed.

Adult↗
PubMed1988

[Subacute subdural hematoma associated with moyamoya phenomenon--a case report].

A case of subacute subdural hematoma associated with moyamoya phenomenon is reported. On May 8, 1986, a 61-year-old female was referred to Mito National Hospital for evaluation of a left-sided hemiparesis and headache 8 days after minor head injury. Seventeen years ago she experienced the sudden onset of a left-sided hemiparesis which improved by rehabilitation. CT scans showed a thin high density area on the right cerebral convexity and a small low density area in the right semiovale center. On May 12, she was admitted because of aggravation of her symptoms. A repeat CT scan showed an enlarged right temporoparietal subdural hematoma with significant mass effect. Cerebral angiograms revealed the occlusion of right internal carotid artery. There were so-called moyamoya vessels bilaterally and transdural anastomosis on the right side. Avascular area confirmed subdural hematoma. The hematoma was evacuated via two burr holes with preservation of the middle meningeal and superficial temporal arteries. By the time of discharge two months postoperatively, she was walking well without assistance. We reviewed four cases of acute or subacute subdural hematoma associated with moyamoya phenomenon and emphasized the possibility of occurrence of acute or subacute subdural hematoma due to rupture of vault moyamoya vessels.

Arterial Occlusive Diseases↗
PubMed1987

Continuous recording of cerebral blood flow by means of a thermal diffusion method using a Peltier stack.

The thermal diffusion method is known to be effective for making quantitative measurements of blood flow, but cannot be easily applied to problems concerning quantitative changes in blood flow. Carter et al. found that the thermal diffusion technique using a Peltier stack as the probe produced extremely stable recordings and was suitable for quantitative work. We made a more stable probe containing an air space and having a stainless cap that added weight. A stable recording of blood flow was then possible. For calibration of the probe, we used blood flow values measured by means of an electrolytic technique and the equation proposed by Carter et al. In the present study, we have shown that it is theoretically possible to perform the calibration even without obtaining data on blood flow after cardiac arrest. Experimentally, the validity of such calibration was confirmed. This technique for measuring blood flow should be applicable in various fields and its use in a clinical setting, particularly in the monitoring of blood flow during neurosurgical operations, can be expected.

Animals↗
PubMed1985

Spontaneous bilateral extradural hematomas. Case report.

Spontaneous extradural hematomas are rare and may be caused by pericranial infections, bleeding tendencies, or vascular abnormalities of the dura mater. The authors describe a case of spontaneous bilateral extradural hematomas assumed to be caused by a bleeding tendency with hypofibrinogenemia. A brief review of the literature is reported.

Adult↗
PubMed1985

[Neurofibromatosis with occlusion of the internal carotid artery: case report].

Vascular lesions of the central nervous system in neurofibromatosis (NF) are uncommon. Cerebral arterial occlusive diseases in NF have been documented in only 29 patients. This paper reports a case of a 16-year-old male having occlusion of the right internal carotid artery with NF. He was admitted with an episode of clonic convulsion and left hemiparesis at the age of five years. On admission, he had multiple café-au-lait spots, depigmentation and fibroma molle throughout his body. Neurological examination revealed left hemiparesis with hypereflexia and pathological reflex on the left side. CT scan showed brain atrophy of the right hemisphere and low density area in the white matter of the right frontal lobe. Cerebral angiography showed occlusion at the extracranial portion of the right internal carotid artery. He underwent STA-MCA bypass on the right side. On histological examination of a section of STA, the intimal layer was thickened by elastofibrosis. The mechanisms of arterial occlusion in patients with NF are discussed with review of the literature.

Adolescent↗
PubMed1984

[A case of multiple aneurysms at the distal portion of the posterior inferior cerebellar artery].

We present a case of multiple aneurysms of the posterior inferior cerebellar artery (PICA) at the distal portion, which is very rare. A 62-year-old woman was admitted to our hospital with complaint of a severe headache. Four-vessel study was carried out and we found one aneurysm in the retromedullary segment of the right PICA. The aneurysm was clipped through the median suboccipital approach. But postoperative angiography showed that aneurysm was not being clipped and the clip was seen about 1 cm proximal to the aneurysm. We concluded that she had two aneurysms and the second operation was performed. The second aneurysm was found about 1cm distal of the one first clipped. The histological finding of the first clipped aneurysm was a degenerative change of slight cellular swelling of the muscle layer. The patient died 10 days after the second operation from fluminant hepatitis and autopsy was not performed. We made a review of the literature about the incidence of multiple aneurysms at the distal portion of PICA.

Arteries↗
PubMed1984

[Spontaneous bilateral extradural hematomas: a case report].

A rare case of spontaneous bilateral extradural hematomas probably due to hypofibrinogenemia is reported. On April 17, 1983, a 21-year-old woman was referred to our hospital because of her comatose state. She has complained of her longer duration of menstrual bleeding lasting 10 days to 2 weeks, but has had no history of hemorrhagic diseases. At the last night, she complained of headache and vomited several times, after drinking some beer but she went to bed without therapy. We cannot see a history of her head injury several days before admission. On admission, she was comatose with bilateral dilated pupils and flexed her upper extremities against painful stimuli. There was a tendency for subcutaneous hematomas to form immediately in places where the stimuli were applied. Skull fracture was not found on craniogram and CT scan showed bilateral extradural hematomas (60 ml on the right side and 130 ml on the left side). Laboratory data showed leukocytosis (14800), longer prothrombin time (15.2 seconds with a control of 11.9 seconds), markedly elongated activated partial thromboplastin time (90 seconds with a control of 15-45 seconds) and decreased fibrinogen concentration (114 mg/dl with a control of 200-400 mg/dl). At the bilateral decompressive craniectomies with infusion of 5 gram of fibrinogen and 300 ml of fresh blood, we found neither scalp hemorrhage nor skull fracture and after removal of coagulated hematomas no dural anomaly was found. After operation she improved gradually and laboratory re-examination was normal including bone marrow puncture. Now, 5 months after operation she is clear with slight tetraparesis on her rehabilitating course.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Case of multiple calcifications of the cerebellar hemisphere].

A 38-year-old woman with three intracerebellar calcifications visible in roentgenogram was reported. She had not suffered from any disease that should induce intracranial calcification. Plain x-ray films of the skull showed three small calcifications in the posterior fossa. The laboratory study and neurological examination revealed no abnormality. Computerized tomography showed no abnormal findings either. Histological examination was carried out. The tissue surrounding the calcification seemed to be gliosis.

Adult↗
PubMed1982

Computer tomography of ruptured intracranial arteriovenous malformations in the acute stage.

We studied the CT findings of 23 AVM cases confirmed by cerebral angiography and their clinical findings, and discussed mainly the lesions of ruptured AVM in the acute stage. The 10 cases, in which CT was performed within 7 days after the onset of a ruptured AVM, presented with blood stained CSF except for two cases. All of the 10 cases showed intracerebral haemorrhages in the CT findings, and four of these cases were associated with ventricular rupture. In the plain CT of these 10 cases, high density in the cerebral cistern, such as seen in the acute stage of ruptured intracranial aneurysms, was not found except for 1 case. In the enhanced CT within 7 days after the onset of ruptured AVM, no enhanced findings were found in eight cases. On the contrary, in 12 cases in which CT was performed later than the 8th day after the onset, enhanced findings were found in 11 cases. It has been previously reported that SAH is seen in the lesion of ruptured AVM in the acute stage. From our CT findings of ruptured AVM in the acute stage, however, it was concluded that the lesion of a ruptured AVM in the acute stage does not cause SAH but an intracerebral haematoma or ventricular rupture and that blood may enter the CSF only secondarily.

Acute Disease↗
PubMed1982

[Chronic subdural hematoma developing after EMS for moyamoya disease].

A case of chronic subdural hematoma following EMS (Encephalo-Myo-Synangiosis) for moyamoya disease was presented. Two and a half year-old girl was admitted to our division because of right hemiparesis. Left carotid angiography revealed a very narrow left carotid bifurcation and small moyamoya vessels. EMS was performed on the left side and a right hemiparesis was improved. But she developed a headache and vomiting one month after the operation. CT scan and angiogram showed a chronic subdural hematoma on the left side. A hematoma weighing approximately 30 g was evacuated. We reviewed a similar case of 5-year-old boy in the literature and discussed the mechanism accounting for formation of the chronic subdural hematoma following EMS.

Arterial Occlusive Diseases↗