A conditioned medium (CM) factor produced by chondrocytes that promotes their own differentiation.
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Animals↗
Biomedical subjects
M Solursh
Publications and source records attributed to M Solursh.
Mediation of growth hormone-enhanced expression of the cartilage phenotype in vitro by the availability of the essential amino acid valine.
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Animals↗
The requirement for RNA synthesis in the differentiation of cultured chick embryo chondrocytes.
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Animals↗
Long-term cell culture of two differentiated cell types from the liver of larval and adult Xenopus laevis.
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Acid Phosphatase↗
Stimulation of sulfate incorporation by growth hormone treatment of cultured chick embryo chondrocytes.
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Animals↗
The comparative effects of several mammalian growth hormones on sulfate incorporation into acid mucopolysaccharides by cultured chick embryo chondrocytes.
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Animals↗
Immunohistochemical localization of TGF-B1 during morphogenetic movements of the developing mouse palate.
Transforming growth factor-beta (TGF-B1) may play an important role in developmentally active tissues in which it is found in high concentrations. We localized TGF-B1 in the developing fetal mouse palate immunohistochemically using a polyclonal antibody. Mouse fetal palates at 12-17 days (inclusive) of gestation were examined and specific focal concentrations of TGF-B1 identified regions undergoing active morphogenesis. The association of TGF-B1 with aggregates of mesenchymal cells in the palate and chondroblasts, rhabdomyocytes, and epithelia of the craniofacial complex strongly implicates its role in proliferation and differentiation in the developing mouse palate. We believe these findings have important bearing on the normal development of the palate as well as cleft anomalies.
Animals↗