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M Sliwinski

Publications and source records attributed to M Sliwinski.

42 records · Page 3Linked to original sources
PubMed1978

[The use of dopamin in shock and heart failure (author's transl)].

The action of dopamine was evaluated in 18 patients with cardiogenic shock after myocardial infarction, in 14 patients with heart failure and in 18 patients with low-output syndrome after cardiac surgery. In the patients with shock, dopamine increased significantly systolic arterial blood pressure, myocardial contractility, diuresis and sodium excretion. In patients with heart failure a great increase in diuresis and sodium excretion with decrease of CVP was observed. In patients after cardiac surgery dopamine produced a significant increase of arterial blood pressure and diuresis with decrease of CVP. The clinical application of dopamine and the advantages of the use of dopamine combined with other catecholamines were discussed.

Blood Pressure↗
PubMedDate not supplied

A change point model for estimating the onset of cognitive decline in preclinical Alzheimer's disease.

Dementia is characterized by accelerated cognitive decline before and after diagnosis as compared to normal ageing. Determining the time at which that rate of decline begins to accelerate in persons who will develop dementia is important both in describing the natural history of the disease process and in identifying the optimal time window for which treatments might be useful. We model that time at which the rate of decline begins to accelerate in persons who develop dementia relative to those who do not by using a change point in a mixed linear model. A profile likelihood method is proposed to draw inferences about the change point. The method is applied to data from the Bronx Ageing Study, a cohort study of 488 initially non-demented community-dwelling elderly individuals who have been examined at approximately 12-month intervals over 15 years. Cognitive function was measured using the Buschke Selective Reminding test, a memory test with high reliability and known discriminative validity for detecting dementia. We found that the rate of cognitive decline as measured by this test in this cohort increases on average 5.1 years before the diagnosis of dementia.

Aged↗
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How strong is the evidence for mediational hypotheses of age-related memory loss? Commentary.

BACKGROUND: Luszcz and Bryan review research supporting three theories of age-related memory loss: the speed hypothesis, the executive function hypothesis, and the common cause hypothesis. OBJECTIVE: The aim of this commentary is to extend that review by encouraging consideration of the strength (or lack thereof) of the empirical evidence supporting theories of age-related memory loss. METHODS: Arguments are presented that call into the question the strength of the evidence that derives from cross-sectional analysis of individual difference sources of variance. RESULTS: Supporting evidence for mediational hypotheses of cognitive aging (1) derives from potentially ambiguous statistical techniques; (2) is based on untested assumptions about the between and within person sources of variance; (3) is not supported by longitudinal studies, and (4) relies heavily on arguments of parsimony. CONCLUSIONS: Existing evidence is not strong enough to grant any particular theory presumptive status. We concur with Luszcz and Bryan that supplementing the now popular individual differences research designs with alternative approaches would advance theory development and testing.

Aging↗