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Biomedical subjects

M Slapak

Publications and source records attributed to M Slapak.

At least 19 recordsLinked to original sources
PubMed1997

Organ donation: Transplant Games, the "Island Effect," and other successful methods.

We have alluded to data showing that effective organisation has a well-documented effect on organ donation. We have also presented data demonstrating the positive effect of the Transplant Games on public opinion and through positive media influence, producing a very marked increase in organ donation. Attention has also been drawn to the surprising phenomenon we call the "Island Effect," which may endorse the concept of decentralisation and close communication as an effective way of increasing organ donation. Finally, we conclude that, with professional help, both into the organisation of organ donation, and the creation of a positive media effect on public opinion, there is a great scope for increasing human organ donation to levels that are very much higher than that which we now experience. Both the Transplant Games and the "Island Effect" have indicated routes that we can and must explore and use to narrow the vital gap between organ need and organ supply for transplantation.

Cadaver↗
PubMed1996

Acute renal failure in general surgery.

The high mortality and morbidity can be significantly reduced by three cardinal steps: 1. Early diagnosis of intrinsic renal failure 2. Early institution of fluid restriction and dialysis 3. The identification of patients who are likely to be at high risk from acute renal failure, and the careful planning and institution of available therapeutic measures to prevent it.

Acute Kidney Injury↗
PubMed1995

Renal autotransplantation for aortic dissection in Marfan's syndrome.

Marfan's syndrome is an autosomal dominant condition with a prevalence of 4 to 6:100,000, and classically comprises skeletal changes, ectopia lentis and cystic medial necrosis of the largest arteries. The latter leads to aneurysm formation, most often commencing at the aortic root, and is responsible for an average age at death of 32 years. We describe successful preservation of threatened renal function by renal autotransplantation, without concurrent aortic replacement, following dissection of the descending aorta in a patient with Marfan's syndrome.

Adult↗
PubMed1992

Lack of correlation between IgG T-lymphocyte flow cytometric crossmatches with primary renal allograft outcome.

The flow cytometric crossmatch (FCXM) has been reported to be more sensitive and capable of detecting very low levels of antibodies than the normally used complement dependent cytotoxicity test. We studied both the two colour IgG T cell FCXM and CDC-XM in 146 renal allograft recipients, 111 primary and 35 regrafts, of which 26% (29/111) of 1st and 20% (7/35) of regrafts had a positive FCXM. There was no overall correlation between the FCXM results and early graft outcome in primary renal allografts. The FCXM did not appear to have any advantage over the CDC-XM in predicting graft outcome in unsensitized first grafts. In the small number of regrafts studied, a positive FCXM was associated with a higher degree of graft failure. FCXM can exhibit false negative results if sera are used solely neat although these prozone phenomena do not influence subsequent graft outcome.

Adult↗
PubMed1991

Triple therapy.

Explore the source record for details and available documents.

Animals↗
PubMed1989

Tendinitis--a common complication after renal transplantation.

A group of 170 patients having functional renal allografts were evaluated at least six months after renal transplantation. They were assessed for symptoms and signs of tendinitis in the Achilles and Supraspinatus tendons. Of the 170 patients, 34 had tendinitis. Four patients (11.8%) had spontaneous rupture of the Achilles tendon one week to 72 months after transplantation. All of the symptomatic patients had received steroids, and 81% of these had been treated with methylprednisolone. Of the asymptomatic patients 89% received steroid and 69% received methylprednisolone. There was a significant correlation between symptoms of tendinitis and the cumulative steroid dose. The number of matching HLA loci of the donor kidney and the length of time on dialysis were also related to the incidence of tendinitis. Unlike a previous study (1) we could not find significant differences between the 34 patients with tendinitis and controls with reference to the levels of serum phosphate, alkaline phosphatase, albumin adjusted calcium, or cholecalciferol therapy prior to transplantation. Our data confirm that tendinitis is surprisingly common in patients after renal transplantation (20.0%).

Achilles Tendon↗
PubMed1988

Detection of kidney reactive antibodies at crossmatch in renal transplant recipients.

We have investigated retrospectively sera from 70 renal allograft recipients for the presence of antibodies binding to a preanastomosis biopsy of the donor kidney by an indirect immunoperoxidase technique. All recipients had a negative T cell lymphocytotoxic crossmatch. A positive immunoperoxidase crossmatch for kidney-reactive antibodies was seen in 13/70 (18.6%) recipients--6 reacting with endothelium, 4 with epithelium, and 3 with both cell types. Neither the presence of these antibodies nor their pattern of staining correlated with recipient graft outcome. Following transplantation endothelial reactive antibodies developed in 15/43 (35%) patients, whereas tubular epithelial antibodies occurred in 5/43 (12%). The antibodies were persistent and accompanied graft failure in 10/14 (71%) patients, while transient antibodies were only associated with graft failure in 2/12 (17%) recipients. Development of lymphocytotoxic antibodies did not correlate with the presence of renal reactive antibodies or eventual graft outcome. Smooth muscle and antinuclear antibodies in recipient sera prior to transplantation were associated with improved graft survival. Eluates of 8/14 rejected grafts confirmed the presence of renal reactive antibodies, with patterns of staining similar to those observed in recipient sera. Antibodies in 7/8 recipients were shown by absorption studies to have HLA class I and/or II specificity, the remaining recipient having proximal tubular brush border antibodies.

Adolescent↗