Intestinal absorption and autoimmunity in endocrine disorders.
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Biomedical subjects
M Siurala
Publications and source records attributed to M Siurala.
The Sydney System: epidemiology and natural history of chronic gastritis.
Chronic gastritis is a common disease which forms an important background to the pathogenesis of several gastric diseases. In most instances, gastritis seems to be a bacterial (microbial) disease. It begins as long-lasting, chronic inflammatory reaction directed against Helicobacter pylori (HP), or occasionally against other spiral bacteria, which colonize in the space between the surface epithelium and the mucous layer. Gastritis may, irrespectively of the HP-related or HP-independent origin, progress to an atrophy (chronic gastritis with atrophy) in the underlying mucosa. Prevalence of gastritis increases with increase in age, but great variations exist in the age-specific prevalence and in mean age of onset of the gastritis in different populations. A high rate and an early onset of the HP-related gastritis associates with low socio-economic status. Chronic gastritis, and the gastritis with atrophy in particular, may interfere with the function of the affected gastric mucosa, and may subsequently increase or decrease the risk of some gastric diseases, such as cancer and peptic ulcer. Both antral and corpus gastritis with coexistent severe atrophic changes have been shown to be associated with an increased risk of gastric cancer. In addition, gastritis seems to also play an important role in the pathogenesis of peptic ulcer. Virtually all patients with DU and GU have coexisting and preceding gastritis. The cumulative risk of ulcer has been estimated to be high in subjects with gastritis, but, in contrast, to be low in subjects who have normal gastric mucosa.
Adolescent↗
[Chronic gastritis, a physiological symptom of aging?].
In order to answer the question we have tried to evaluate, firstly, whether the age-dependent increase of the prevalence of gastritis is due only to a regular recruitment of new cases associated with poor remission tendency, or whether some age-specific factors are participating, and secondly, whether gastritis is able to cause abdominal complaints. Dynamic evaluation of the age-behaviour of gastritis in first-degree relatives of patients with pernicious anaemia demonstrated the presence of age-specific factors, which facilitate the progression of gastritis in older age. The nature of these factors is, however, unknown. A significant association could be demonstrated between the presence of all gastritis and the B-type of it and the occurrence of upper abdominal complaints in a representative sample of a Finnish population. However, a considerable proportion of the gastritis cases with complaints had peptic ulcer, gallstones or hiatal hernia, which could better explain the occurrence of complaints than gastritis. It is concluded that gastritis is no disease in clinical sense, however, it is not a physiological aging phenomenon either, as is demonstrated by the present dynamic evaluation and the relations of gastritis to clinically important diseases, such as peptic ulcer, polyps, gastric carcinoma and pernicious anaemia.
Adolescent↗
Family patterns of antro- fundal gastritis.
311 first-degree relatives of 78 consecutive patients with gastric carcinoma and 386 first-degree relative of control probands computer matched from a large Finnish population were studied by means of biopsies from antrum and the fundus and by functional and immunological methods. Both the A and B type of Strickland the McKay as well as the AB types of Pitchumoni and Glass were discernable in the present series and often accumulated in the same families. Particularly the A type associated with high serum gastrin values and parietal cell antibodies revealed a family accumulation. In general members of the same family tended to behave similarly with regard to morhology, function and immunology of the antro-fundal mucosa. The 386 computer matched controls from the general population were treated by means of mathematical methods derived from stochastic theory. It appeared that on a family level there was clearly discernable a line representin families with predominance of fundal gastritis (A type?) which significantly deviated from the main population. However, no such behavior was found as to the families with predominantly antral gastritis (B type?) which behaved like the population at large.
Antibodies↗