Biomedical subjects
M Siegelbaum
Publications and source records attributed to M Siegelbaum.
A prospective evaluation of placental lactogen as a test for neonatal risk.
This study evaluates the usefulness of maternal serum concentrations of human placental lactogen in the management of high-risk pregnancies. The study was performed in a community hospital over a year's time and involved 250 gestations. The test detected only 11.4% of the pregnancies defined as high-risk by clinical criteria and none of the pregnancies in which the newborn was compromised. Serum human placental lactogen is an insensitive test in predicting the outcome of pregnancies in an obstetric population unless historical information regarding maternal disease is unavailable.
Use of doxycycline in elective first trimester abortion.
Elective first trimester abortion was performed in 263 patients, including 86 control patients and 177 patients receiving doxycycline as prophylactic antibiotic coverage. Abortions were done by the same physicians, using a standard protocol. Control and study populations had similar courses, except that the incidence of major complications and total complications was significantly reduced in the group receiving doxycycline. No untoward reactions to the drug were noted, and patient compliance was excellent. The results suggest that the low morbidity of elective suction abortion is further reduced by prophylactic doxycycline.