Search PubMed⌕ Search

Biomedical subjects

M Shirataka

Publications and source records attributed to M Shirataka.

22 records · Page 2Linked to original sources
PubMed1980

A multivariate factor analysis of the high plasma concentration of cyclic AMP in patients with chronic renal failure.

The concentration of cyclic AMP which is known as an intracellular mediator of hormone action increased in the plasma of patients with chronic renal failure (CRF). In the present study, the plasma concentration of cyclic AMP significantly correlated not only with serum, creatinine, and urea levels, but also with plasma PTH and glucagon in patients with CRF. Furthermore, plasma concentrations of PTH and glucagon correlated with the serum creatinine concentration to a significant extent. To discuss the cause of the increased cyclic AMP concentration in plasma of patients with CRF, multivariate analyses were carried out on the obtained clinical data from patients and normal subjects. In the factor analysis on the clinical data from 61 subjects, cyclic AMP, creatinine and BUN correlated with the first factor and PTH correlated with the second factor. The cumulative contribution ratio by the second factor was 76%. The results of the cluster analysis indicated that cyclic AMP, creatinine, and BUN formed a cluster and PTH glucagon made another cluster. These results suggest that the elevated plasma concentration of cyclic AMP in patients with CRF was mainly introduced not by overproduction but by the retention of cyclic AMP due to the decreased renal function.

Adult↗
PubMed1979

Estimation of body water and salt contents from plasma sodium, protein concentrations, and hematocrit.

New formulae for the estimation of change in water (delta W) and salt (delta NaCl) contents of the body from hematocrit, plasma Na, and protein concentrations were proposed based on a compartment model of body fluid regulation: delta W = 0.4(delta Vi/Vi0) + 0.2(delta Ve/Ve0) litres/Kg of body weight; delta NaCl = 1.64[delta Ve/Ve0 + 1)/(delta Vi/Vi0 + 1) - 1)-1] Gms/Kg of body weight; where delta Vi/Vi0, and delta Ve/Ve0 are relative increment of intra and extracellular fluid volume. delta Vi/Vi0 is considered equal to ([Na]0/[Na]-1) under the condition of normal cell membrane, whereas delta Ve/Ve0 may be a nonlinear function of relative increment of plasma volume and hematocrit or sodium concentration. Thus a nomograph was presented to obtain delta W and delta NaCl simultaneously. This nomograph could predict delta W and delta NaCl with satisfactory accuracy in the experiments with the dogs to which fluid of various osmolarity was given intravenously. It was also confirmed in a case of mixed water depletion in which the clinical estimation agreed with that of the present method. The conventional formulae of calculation based on either pure dehydration or purse salt loss proved not to be applicable in the usual cases of body fluid disturbances.

Animals↗