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Biomedical subjects

M Shimono

Publications and source records attributed to M Shimono.

At least 109 records · Page 6Linked to original sources
PubMed1985

Morphometry of cytoarchitecture of the lateral hypothalamic area in the rat.

The cytoarchitecture of the lateral hypothalamic area (LHA) in rats was studied with cresyl violet-stained coronal celloidin sections and with sections of the brain impregnated by a Golgi method. Unimodality was established in the frequency distribution histogram of both the somatic cross-sectional area of the LHA neurons and somatic shape (elongation and circularity). The predominant somatic orientation was in the dorsomedial-ventrolateral direction: bimodality of the frequency distribution of somatic orientation was denied. These findings suggest that the LHA neurons examined in the present study are not subdivisible on the basis of the somatic area, shape or orientation. Although the neurons were classified into eight types based upon the dendritic pattern, those in the LHA largely consisted of only three of them; Type III (dendrites extending in two directions along the long axis of soma), Type IV (three directions) and Type VIII (four directions) jointly accounted for 97.1 percent of the total neurons examined. This finding suggests that the parameter of dendritic pattern serves an important purpose in the typing of the rat LHA neurons. The orientation of intrinsic dendrites and intrinsic axons in the LHA has also been described.

Animals↗
PubMed1984

Intercellular junctions in odontoblasts of the rat incisor studied with freeze-fracture.

The morphology and distribution of various types of intercellular junctions were investigated in young odontoblasts. Gap junctions were found between odontoblasts as well as between odontoblasts and fibroblasts in the dental pulp. The junctions between odontoblasts were larger and more numerous than those between odontoblast and fibroblast, suggesting that the former may play an important role in regulating cellular activity and the latter may provide a pathway of low electrical resistance between odontoblast and nerve fibres. Irregularly-shaped gap junctions appeared as small aggregations of particles associated with a particle-free area and may indicate that the junction might not yet have been completely assembled. Tight junctions were observed at the distal ends of the young odontoblasts, arranged to form small maculae or faciae occludentes rather than belt-like zonulae. It is therefore not likely that the junction contributes to barrier function in the young odontoblasts. Although structures resembling typical desmosome were recognizable, this type of junction in odontoblasts is properly termed a desmosome-like junction from its morphological peculiarities.

Animals↗
PubMed1984

Acinic cell carcinoma arising in the glossopalatine glands: a report of two cases with electron microscopic observations.

Two cases of acinic cell carcinoma arising in the glossopalatine glands were examined with the electron microscope by means of conventional thin sectioning and freeze-fracturing. Light and electron microscopic observation revealed that the tumors consisted of three types of cells: serous-type, ductlike, and vacuolated cells. Serous-type cells had numerous secretory granules, some of which were discharged into the intercellular spaces. Ductlike cells were smaller, usually lacked secretory granules, and were similar to intercalated duct cells. Vacuolated cells had electron-opaque vacuoles in the cytoplasm. Our findings supported the hypothesis that acinic cell carcinoma may represent a neoplasm of multipotential duct cells which have differentiated mainly into granulated serous cells. Freeze-fracture images of this tumor revealed that tight junctions were composed of ten or more interlinked strands with elongation of basal frontier strands. These findings suggested that the junctional morphology of the tumor resembled that of developing salivary glands and was associated with the degree of cellular differentiation.

Carcinoma↗
PubMed1984

The evaluation of a new synthetic pyrethroid pesticide (permethrin) for neurotoxicity.

A new synthetic pyrethroid, permethrin, has recently been granted a registration by the United States Environmental Protection Agency. Permethrin and a large number of other chemicals of its type are expected to receive widespread use in the environment in the near future. Since the mechanism by which these compounds exert their toxic effect in insects (and at higher doses in mammals) is by disruption of the normal function of nervous tissue, a detailed morphologic evaluation of the nervous system was performed on rats from two long-term feeding studies conducted on permethrin. In this evaluation, examination of central and peripheral nervous plus examination of extensive morphometric data and teased myelinated fibers of distal sural and tibial nerves and of the maxillary division of cranial nerve V did not reveal any changes which could be attributed to the feeding of the pesticide.

Animals↗
PubMed1983

[Case of Borrmann III stomach cancer effectively treated by UFT therapy (co-administration of uracil and futraful)].

Through X-ray and endoscopic examination of stomach, a 77 year-old man, who complained of epigastralgia, he was diagnosed to have Borrmann III type gastric carcinoma on the antrum. The gastric biopsy specimen obtained from the tumor revealed to be well differentiated adenocarcinoma. Since the patient refused receiving surgical treatment, a combined administration of futraful and uracil (UFT therapy) was performed. 4 weeks after receiving UFT therapy, the patient became less aware of subjective symptom and the gastrofiberscopic picture showed smaller mass lesion compared to that of prior to the treatment. 8 weeks later, the tumor was remarkable reducing its size. When compared 14 cases of gastric carcinoma receiving UFT therapy with 26 cases receiving Futraful therapy (FT therapy), the UFT group responded more effectively than the FT group. In the UFT therapy, complete (CR) and partial response (PR) were obtained in 4 of 13 cases of gastric carcinoma with an effective rate of 30.8% according to the response criteria proposed by the Koyama-Saitoh group and with a Karnofsky scale of IA or better in 6 (42.8%) of 14 cases. On the other hand, in the FT therapy CR and PR were obtained in 5 of 26 cases with that of 19.2%, while a Karnofsky scale of IA or better was achieved in 6 (23.1%). As for 3 cases of PR in the UFT therapy the microscopic view of the biopsy specimen from gastric carcinoma showed well differentiated adenocarcinoma, which responded to the UFT therapy remarkably 4-5 weeks after receiving UFT therapy.

Adenocarcinoma↗