New drugs for mental disorders?
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Biomedical subjects
Publications and source records attributed to M Shepherd.
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Data from a large-scale (N greater than 3000) community survey (the 'West London Survey') were used to examine the effect of minor psychiatric morbidity on the probability of contact with primary medical care, and factors which influenced this effect. The presence of such morbidity was found to double the probability of consulting, and about one-fifth of consultations could be attributed to it. Logistic analysis was used to investigate the joint effect on general practice consultation of minor psychiatric morbidity, three other health-related variables and five sociodemographic variables. It was found, as expected, that the health variables exerted much more influence on consulting than the sociodemographic variables, but that the relationship was characterized by complex interactions between health and sociodemographic variables. In particular, sex, socioeconomic status and minor psychiatric morbidity interacted in their effect on the probability of general practitioner consultation. The findings are interpreted in the context of previous theoretical and empirical work.
An outline is provided of an experimental study of the classification of mental ill-health presented to general practitioners (GPs). Videotaped real-life consultations were assessed by 27 GPs for the purpose. A high degree of inter-observer variation was recorded. Some of the implications of the findings are discussed.
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A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant difference between the prophylactic efficacy of the 2 antidepressants. An account is given of the relative adverse effects of the treatments, and the implications of the findings are discussed.
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