Search PubMed⌕ Search

Biomedical subjects

M Sharma

Publications and source records attributed to M Sharma.

At least 397 records · Page 22Linked to original sources
PubMed1981

Frequency and significance of fungal isolations from conjunctival sac and their role in ocular infections.

Five hundred conjunctival swabs, from 150 males and 100 females with no history of ocular infections, were collected and cultured for the isolations of fungi. Eighty (16%) of the total specimens yielded positive fungal isolations. The isolation rate was more from the males than the females subjects. Mycelial fungi were predominant than the yeast organisms. Aspergillus species were the commonest isolates with A. flavus taking the lead in the isolations being positive 16 of the total 24 Aspergillus species isolated. A variable rate of fungal isolations was observed in different months of the year. The percentage of the isolations increases after the local use of Efcorlin-N. Nineteen of the 20 eyes studied did not yield the same fungal species in the repeated samples.

Adolescent↗
PubMed1981

Interaction of prolactin and testosterone in the human prostate.

Three experiments were performed to determine whether human prolactin (hPr) affects prostatic uptake and metabolism of testosterone (T). 1) Patients with prostatic cancer were infused twice with radio-labelled androgens, the first time with basal hPR, the second time with oral thyrotrophin-releasing hormone (TRH)-elevated hPr. In 5/7, significant increases in metabolic clearance of dihydrotestosterone (DHT) and in conversion of T to DHT accompanied increased hPR. 2) The incorporation of labelled T into minced benign prostatic hypertrophy (BPH) tissue from subjects with high (40 ng/ml) hPR was measured and was found to be more than twice the uptake into tissue from those with low hPR (6.5 +/- 1.9 ng/ml). 3) Uptake and metabolism in vivo of a bolus of 3H-T by BPH and carcinomatous prostates was measured and was far greater in subjects whose hPR was elevated by chlorpromazine than in untreated controls. It is concluded that prolactin increases prostatic uptake and metabolism of T. It is suggested that the best management of prostatic cancer should include depletion of prolactin as well as androgen.

Dihydrotestosterone↗
PubMed1981

Derivatives of n-aryl-N-amino piperazines as potential cardiovascular agents.

24 new substituted piperazino guanidines and 34 substituted benzylideno- or benzylamino-4-phenyl piperazines were synthesized and evaluated for their cardiovascular activity. Several compounds of the above two series exhibited vasopressor or vasodepressor activity without modifying the carotid occlusion (CO) and noradrenaline (NA) induced pressor responses.

Animals↗
PubMed1980

Modifications at C-3 and C-4 of 2-amino-2-deoxy-D-glucose.

Modifications at C-3 and C-4 of 2-amino-2-deoxy-D-glucose have been developed. A 3,4-double bond was introduced into benzyl 2-acetamido-2-deoxy-3,4-di-O-methylsulfonyl-alpha-D-glucopyranoside by treatment with NaI and Zn. Epoxidation of the double bond with m-chloroperoxybenzoic acid gave an exo-epoxide exclusively. The stereochemistry of the epoxidation product has been confirmed by an alternative synthesis. An analysis of the 1H-n.m.r. spectra indicates that both the 3,4-unsaturated derivatives and the epoxide exist in the OH1 (D) conformation. Nucleophilic reagents (F-, I-) opened the 3,4-epoxide to give 4-substituted derivatives having the D-gulo configuration. Thus, 2-acetamido-1,3,6-tri-O-acetyl-2,4-dideoxy-4-iodo-alpha-D-gulopyranose and 2-acetamido-1,3,6-tri-O-acetyl-3,4-dideoxy-4-fluoro-alpha-D-gulopyranose have been synthesized. Reduction of the double bond in the key intermediate and deprotection gave 2-acetamido-2,3,4-trideoxy-D-glucopyranose. Some of the derivatives were active as inhibitors of growth of mouse, mammary adenocarcinoma cells in culture.

Adenocarcinoma↗