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Biomedical subjects

M Sharf

Publications and source records attributed to M Sharf.

117 records · Page 7Linked to original sources
PubMedDate not supplied

Postpartum maternal group B streptococcal meningitis.

Maternal group B streptococcal (GBS) meningitis is rare, with only four cases previously reported in the literature. In this review a fifth case of postpartum GBS meningitis is presented. The five cases are compared with 34 cases of GBS meningitis in nonparturient adults. All cases of maternal GBS meningitis followed a vaginal delivery. The mean age of patients who had GBS meningitis outside the perinatal setting was 55 years, and most of these individuals had associated illnesses or frank immunosuppression; the mortality rate in this group was 23%. In contrast, all five patients with maternal GBS meningitis recovered. The case presented herein, like the four previous cases, illustrates the point that when patients with maternal GBS meningitis are treated immediately and have been healthy before the infection, the prognosis is good.

Adult↗
PubMedDate not supplied

Candida sepsis in pregnancy and the postpartum period.

Colonization of the vagina by Candida is common during pregnancy, while candida sepsis in pregnancy is rare. A case of candida sepsis complicating an abortion prompted us to review seven additional cases that occurred during pregnancy or the postpartum period. In four women candidemia developed during pregnancy or following abortion, while in the other four it developed postpartum. Seven women had an apparent predisposing factor, such as antibiotic treatment or an intrauterine device. The clinical course was difficult in four patients and ended in death in three instances. Both amphotericin B and 5-fluorocytosine proved effective for treatment.

Abortion, Septic↗
PubMedDate not supplied

Cervical cerclage in uterine malformations.

This retrospective study represents our experience with cervical cerclage (suture) in pregnancies with uterine malformation. Seventeen patients with uterine malformations were involved. In these patients, the outcome of 31 gestations with cervical cerclage was evaluated. Uterine malformation was associated with cervical incompetence in 41% of the patients. Term delivery rate and fetal loss were observed in 56% and 26% of pregnancies, respectively. Infant salvage was not significantly different regardless of whether cervical incompetence was present or absent. A prolonged hospital stay and frequent use of tocolysis were noted during gestations with cerclage. Our data suggest that the outcome of pregnancies with uterine malformation was not improved by cervical cerclage when the indication for cerclage was the malformation itself.

Adult↗
PubMedDate not supplied

Human gonadotropin therapy: hormonal and ultrasonographic characteristics of conceptual and nonconceptual cycles in the same women.

A retrospective analysis was carried out to assess hormonal and sonographic characteristics of 52 conceptual (P-cycles) and 53 nonconceptual (F-cycles) gonadotropin treatment cycles in the same women. In the P-cycles, an exponential E2 pattern was observed up to the day of hCG (human chorionic gonadotropin) administration (day 0). In the F-cycle group, a similar pattern was observed till day (-1), and then levels plateaued. Forty-two (80.9%) of the pregnancies were achieved when the active phase was 6 +/- 1 days; seven pregnancies (14.8%) occurred when the active phase was more than 7 days. Only one of these pregnancies was a singleton viable pregnancy (P less than .05). It is, therefore, postulated that 6 +/- 1 days rising E2 and exponential E2 rise pattern up to the day of hCG are the two main monitoring variables leading to the highest percentage of viable singleton or twin pregnancies in hMG-stimulated cycles.

Adult↗
PubMedDate not supplied

Emergency versus elective microsurgery.

During a 30-months period, a total of 148 microsurgical gynecological operations were performed in our department. We divided these operations into two groups: Emergency microsurgical operations, where microsurgical technique is used in urgent cases for preservation of fertility potential, and elective microsurgical operations, performed for restoration of fertility. We compared the two groups with regard to their inherent characteristics and differences in therapeutic and prognostic approach towards them. The results of our comparison show, that these two groups having in common only the microsurgical approach, are different from each other in the following points: The average age of the emergency microsurgery group was younger since it contained also prefertility cases; the timing of operations in the elective group was always in the proliferative phase of the menstrual cycle; antibiotics were given pre-, intra and postoperatively only in the elective group; corticosteroids were given intra- and postoperatively only in the elective group; the average number of different operative procedures performed during one operation was higher in the restorative group; desire for pregnancy was always present in the restorative and inconstantly in the preservative group; results of the operations regarding intrauterine pregnancy can be evaluated only for the elective, and not for the emergency group. Psychological evaluation of cases can be performed in the elective and not in the emergency group. Because of these differences, a division of microsurgical operations into elective and emergency microsurgery seems justified and valuable to us.

Adolescent↗
PubMedDate not supplied

Clear cell carcinoma of the endometrium and cervix in postmenopausal women: a case report.

Clear cell carcinoma of the endometrium and uterine cervix is a rare entity. Most of the recent literature deals with its occurrence in young women, and links it with intrauterine exposure to synthetic estrogens. Three cases of clear cell carcinoma in postmenopausal women are presented, with their histopathological findings. The clinical picture, incidence, origin and treatment of this neoplasm are reviewed.

Adenocarcinoma↗