[Experimental program of dental care for pregnant women of the Public Health Department of Uruguay].
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Biomedical subjects
Publications and source records attributed to M Serrano.
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Thirty-eight children with acute epidemic hepatitis (Type A) and 22 children in "contact" with the disease, 5 of whom subsequently developed hepatitis, were studied. Three technics based on laser ray nephelometry were employed to investigate the presence of circulating immune complexes. Our results indicated that circulating immune complexes are present in the serum during the course of epidemic hepatitis. These were demonstrated in 79% of the patients. The capacity to fix complement diminishes as the disease evolves toward the convalescent phase. We also detected a similar percentage of immune complexes (80%) in the patients during the incubation period. In the subjects in "contact" with the disease who subsequently did not develop hepatitis, the immune complexes were shown to have a greater capacity to fix complement, and the percentage of immune complexes present was higher (94%). The specificity of the immune complexes was verified by correlating the antivirus A antibody activity with the percentage of C4 in the precipitates obtained by polyethylene glycol (3.5%).
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A 34-year-old woman had a three-month history of a double mitral lesion. Chest radiographs disclosed a mediastinal mass. Thoracotomy was performed and multiple white nodules and an enlarged thymus were seen. Sarcoidosis and true thymic hyperplasia were diagnosed in the excised white nodules and thymus. A decrease of cell-mediated immunity was also discussed. When commissurotomy of the mitral valve was performed 4 months later, sarcoidosis and true hyperplasia had disappeared and alterations of cell-mediated immunity became normal after a course of steroid therapy. The alterations of cell-mediated immunity, so frequent in sarcoidosis, could be related to true thymic hyperplasia.