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Biomedical subjects

M Serban

Publications and source records attributed to M Serban.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Significance of platelet-activating factor acetylhydrolase in patients with non-insulin-dependent (type 2) diabetes mellitus.

BACKGROUND: Non-insulin dependent diabetes mellitus (NIDDM) represents an independent risk factor for cardiovascular diseases (CVD), being characterized by a continuous low-grade inflammation and endothelial activation state. Plasma platelet - activating factor - acetylhydrolases (PAF-AHs) are a subgroup of Ca(2+)-independent phospholipase A(2) family (also known as lipoprotein-associated phospholipases A(2)) that hydrolyze and inactivate the lipid mediator platelet-activating factor (PAF) and/or oxidized phospholipids. This enzyme is considered to play an important role in inflammatory diseases and atherosclerosis. The present study aims to investigate the relations between the levels of PAF-AH activity and LDL-cholesterol / HDL-cholesterol (LDL-ch / HDL-ch) ratio in NIDDM patients as compared to controls. METHODS: serum PAF-AH activity was measured in 50 patients with dyslipidemia, in 50 NIDDM patients and in 50 controls (normal lipid and glucose levels). Total cholesterol, LDL-ch, HDL-ch, triglyceride and blood glucose were determined in all subjects. RESULTS: All NIDDM patients display hiperlipidemia, with increased LDL-ch and triglyceride levels. There is a significant correlation between LDL-ch levels (especially LDL-ch / HDL-ch ratio) and PAF-AH activity in dyslipidemic and NIDDM patients. CONCLUSION: Diabetic and dyslipidemic patients have an increased plasma PAF-AH activity correlated with their LDL-ch levels and mainly with LDL-ch / HDL-ch ratio. Plasma PAF-AH high levels appear to be important as a risk marker for endothelial dysfunction in patients with NIDDM.

1-Alkyl-2-acetylglycerophosphocholine Esterase↗
PubMedDate not supplied

Prevalence of arterial hypertension in a collectivity of adolescents.

Arterial hypertension in adolescents was studied in a group of 899 school boys aged 15-18 years from the vocational school No. 48 of the Bucharest Transport Enterprise (ITB) and the secondary school No. 19 ITB. Essential arterial hypertension in the group investigated was found in proportion of 2.7%, a percentage comparable with that of other European countries (1-3%).

Adolescent↗
PubMedDate not supplied

[Diabetic nephropathy. I].

The paper reports on the present knowledge in the diabetic nephrosis (DN) with emphasis on three problems: evolution by stages, possibility of detecting the diabetics with high risk of developing clinic DN, and the prophylactic and therapeutic measures required for a resting or, at least, for slowing down the evolution of this complication. The functional changes, manifested mainly by increasing the glomerular filtration, are detected in many insulin-dependent diabetics even from the diagnosis of the disease and they are predictive elements for the clinic DN; that is the reason why they must be reduced by a correct and prolonged control. Microalbuminuria, defined as a urinary excretion of albumin of less than 250 mg/24 hours (18-74 micrograms/minute) is another characteristic of the precocious stages of the DN. Exceeding the above-mentioned values means the transition to the clinic DN, that subsequently progresses in all cases. The paper also describes the characteristics of the clinic DN and the therapeutic ways both in the incipient and clinic DN, with emphasis on their features in the diabetes mellitus and its complications.

Diabetic Nephropathies↗
PubMedDate not supplied

[The significance of psychological risk "patterns" in the recovery of the cerebrovascular patient].

The authors have applied the Jenkins Activity Survey test in 117 patients with residual and sequelae cerebrovascular disorders. Three behavioural types, A, B, and non-A--non-B were determined. A slight prevalence of type A (39.32%) was disclosed by comparison with the two other types, when considered separately although when type-B and type non-A--non-B subjects were lumped together the type A subjects remained a minority. Subjects with marked behavioural patterns were better represented (69.20%), especially those showing factor H. (31.62%), and factor S + H (27.35%).

Adult↗