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Biomedical subjects

M Seishima

Publications and source records attributed to M Seishima.

124 records · Page 7Linked to original sources
PubMed1985

Determination of serum apo A-IV concentration in patients receiving total parenteral nutrition.

Serum apolipoprotein (apo) A-IV levels were determined in patients receiving total parenteral nutrition (TPN) by an immunoassay using a specific antiserum against apo A-IV purified from human sera. The value was significantly lower than that of normal subjects (p less than 0.001), and the level correlated significantly with the duration of TPN. In a patient receiving TPN, serum apo A-IV concentration decreased during TPN and returned to normal levels after resuming oral intake of diet. This finding indicates that serum apo A-IV is a new parameter for nutritional assessment, since the protein is exclusively synthesized in the gut, being different from other rapid turnover proteins which are mainly synthesized in the liver.

Adolescent↗
PubMedDate not supplied

Demonstration of antibody to 230 kDa bullous pemphigoid antigen in lichen planus-like keratosis.

We describe a 67-year-old man with lichen planus-like keratosis associated with anti-230 kDa bullous pemphigoid antigen (BPAG1) autoantibody. The patient had noticed solitary dark brown macule more than 6 years previously on his left chest. Histological findings showed hypergranulosis, irregular acanthosis, liquefaction degeneration of basal cells, band-like infiltration of lymphocytes at the subepidermal portion, and a cleft at the basement membrane zone (BMZ), resulting in the formation of subepidermal blisters. Direct immunofluorescence findings of perilesional skin showed a linear deposition of IgG at BMZ. On indirect immunofluorescent study using normal human skin, circulating IgG autoantibody to BMZ was present in the patient's serum at a titer of 1:80. The antigen located on the epidermal site of normal skin split by 1M NaCl was reacted with the patient's serum. Immunoblot analysis using epidermal extracts demonstrated the presence of IgG antibody directed to BPAG1 in the patient's serum. These observations suggest that the presence of an antibody to BPAG1 could be caused by the damage of basal cells following lichen planus-like keratosis.

Aged↗
PubMedDate not supplied

Raynaud's phenomenon possibly induced by a compund drug of tegafur and uracil.

We describe a 50-year-old woman who noted acral hyperpigmentation, sclerodactyly and Raynaud's phenomenon with 1:160 of antinuclear antibody titer after treatment with a compound drug with tegafur and uracil. Histological findings of the finger and palm included hyperkeratosis, vacuolar degeneration of basal cells, thickened collagen fibers in the dermis, and dilatation of capillary vessels, perivascular mononuclear cell infiltration and melanophages in the upper dermis. IgG, IgA, IgM, C3 and C1q were not deposited in the skin by direct immunofluorescence study. After cessation of the drug, Raynaud's phenomenon and hyperpigmentation disappeared within 1 month and 4 months, respectively, and antinuclear antibody turned negative within 4 months. These observations suggest that tegafur may have caused not only hyperpigmentation in the palms and soles, but also sclerodactyly and Raynaud's phenomenon in the present case.

Antibodies, Antinuclear↗
PubMedDate not supplied

Tick bite by Haemaphysalis megaspinosa - first case.

We describe the first case of tick bite by Haemaphysalis megaspinosa. The tick was found on the skin at the right occipital area in a 5-year-old girl, who had gone on a picnic twice to a mountain 1 and 5 days before she noticed the tick. The tick was surgically removed. The tick was identified as an adult female of Haemaphysalis megaspinosa from its morphological characteristics. This is the first report of tick bite by Haemaphysalis megaspinosa.

Animals↗
PubMedDate not supplied

Mixed connective tissue disease following interstitial cystitis.

A 64-year-old woman complained of severe infrapubic pain and pollakisuria with nausea, vomiting and diarrhea, but with normal urinalysis since 1987. The clinical diagnosis of interstitial cystitis (IC) was made, and cystectomy was performed in 1996. The bladder taken was markedly shrunken with a capacity of 50 ml, and showed bleeding on the mucosal surface. Histological findings of the bladder showed ulcer formation in the mucous membrane, and marked infiltration of mononuclear cells, edema and fibrosis in the submucosal tissue. She had noticed exudative erythema, swelling and sclerosis on the bilateral fingers and dorsal aspects of the hands since 1993, and Raynaud's phenomenon and morning stiffness of the fingers from November, 1998. Laboratory data showed positive anti-nuclear antibody (titer: 1: 2,560) and anti-U1 RNP antibody (titer: 69.5 by ELISA). A diagnosis of mixed connective tissue disease following IC was made.

Cystectomy↗
PubMedDate not supplied

Skin metastasis of breast cancer clinically undistinguished from amyopathic dermatomyositis.

We report a 65-year-old woman who consulted us on May 25, 1998, showing pruritic, partially flagellate erythema on the back and upper extremities, livedo lesions with erythema on the loins, and erythematous papules on the dorsal finger joints for 2 months. Histopathological findings of erythema on the back showed mononuclear cell infiltration around capillaries and marked edema in the dermis. Laboratory data were within normal range except for positive anti-nuclear antibody. She had undergone total left mastectomy on June 2, 1997 for breast cancer. Supraclavicular lymph node metastasis was found at the beginning of May, 1998. A diagnosis of amyopathic dermatomyositis associated with breast cancer was made. Erythema with itching gradually subsided from the end of August, 1998. Treatment with radiation and chemotherapy reduced lymph node swelling, but complete remission was not obtained. Erythema similar to the previous lesion but without itching re-appeared on the back from January, 2000. Histological findings of erythema showed many carcinoma cells similar to the primary lesion of left breast cancer in the whole dermis. A diagnosis of skin metastasis of breast cancer was made. These findings suggest that skin metastasis should be taken into account for patients with erythema on the trunk similar to dermatomyositis.

Adenocarcinoma↗
PubMedDate not supplied

Pemphigus of the eyelids.

We report the case of a 56-year-old woman who presented with a 2-month history of widespread oral erosion and a 3-day history of small papules on the lower eyelids. No other skin involvement was found. Histopathological examination revealed suprabasal cleft and acantholysis in the lower epidermis of the papule on the lower eyelid and in the lower mucous membrane of the oral mucosa. Intercellular deposits of IgG and C3 were seen in the whole epidermis of the specimen from the papule on the right lower eyelid by direct immunofluorescence study. These deposits were also observed in the biopsy specimen from erosion on the left buccal membrane. Indirect immunofluorescence study using normal human skin as a substrate showed intercellular antibodies directed to the cell surface of the whole epidermis with a titer of 1:40. The titers of antibodies to desmoglein 3 and 1 were 118 and 25.9, respectively, by enzyme-linked immunosorbent assay. The patient was treated with an oral administration of prednisolone (0.75 mg/kg/day) for 9 days, which improved the skin eruptions and oral erosion. The dose of prednisolone was gradually tapered and it took 10 weeks to cease this treatment. These findings suggest that this patient is an unusual case of pemphigus vulgaris (mucosal dominant type) diagnosed from the clinical and histopathological findings, with positive antibodies to desmoglein 3 and 1.

Anti-Inflammatory Agents↗
PubMedDate not supplied

Papular mucinosis associated with scleroderma.

A 49-year-old Japanese woman had been suffering from limited cutaneous scleroderma with papular mucinosis. Papular mucinosis was characterized by multiple, asymptomatic, elevated, skin-colored papules on the dorsal regions of the hands. Histopathological findings of the hard papules showed a marked deposition of hyaluronic acid along sclerosis in the middle and the lower parts of dermis. Serological studies revealed a positive antinuclear antibody (speckled type). Intravenous administration of prostaglandin E1 derivatives reduced the size of the papules, the degree of sclerodactyly and the severity of her Raynaud's phenomenon. These observations suggest that manifestations of scleroderma could be found in some cases of papular mucinosis.

Alprostadil↗
PubMedDate not supplied

Antibody to bullous pemphigoid antigen 1 binds to the antigen at perilesional but not uninvolved skin, in localized bullous pemphigoid.

We describe a 59-year-old woman who presented with vesicles, bullae and crusts on her lower legs. Direct immunofluorescence findings for perilesional skin showed linear depositions of IgG and C3 at the basement membrane zone, while no deposition was observed in intact thigh skin, 20 cm distant from the edge of the erosion. On indirect immunofluorescence study using normal human skin, circulating IgG autoantibody to the basement membrane zone (BMZ) was observed in the patient's serum at a titer of 1: 160, which reacted with an antigen located on the epidermal side of normal skin split by 1M NaCl and which stained the BMZ of the thigh skin of the patient that was negative in direct immunofluorescence study. Immunoblot analysis using epidermal extracts demonstrated the presence of IgG antibody directed to 230 kDa bullous pemphigoid antigen (BPAG1) in the patient's serum. These findings suggest that antibody to BPAG1 binds to an antigen uncovered by unknown causes at perilesional, but not at uninvolved skin in the present case of localized bullous pemphigoid.

Autoantibodies↗