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Biomedical subjects

M Sefer

Publications and source records attributed to M Sefer.

At least 19 recordsLinked to original sources

[Studies of oral microbiocenosis. I. Incidence and properties of staphylocci in young persons].

The study of staphylococci in the buccodental washings of 117 second year students at the Faculty of Stomatology, all healthy youths aged 20-25 years, gave the following results: (I) stapphylococci were present in 90% of the students; (II) 50.66% were oral carriers of pathogenic staphylococcal strains; (III) in 23 cases two or more staphylococcal strains were found with different metabolic and biologic properties; (IV) part of the bucal lysozyme was of microbial origin since 95% of the coagulasopositive strains and 88% of the coagulasonegative strains produce lysozymes; (V) 35.23% of the strains yield staphylococcal active with regard to M. lysodeicticus; (VI) 56.19% of the staphylococcal strains were resistant to penicillin and/or tetracyclin, and 5 coagulopositive strains developed in media with a penicillin concentration of 800 u/ml; (VII) 85% of the coagulopositive staphylococci were sensitive to human anti-staphylococcal bacteriophages, the most frequent being phage type 77 of group III.

Adult↗

[New bacterial microorganisms in the etiology of human infections. The genus Gardnerella].

Haemophilus vaginalis first affiliated in the bacterial systems in the genus Haemophilus, the Corynebacterium due to its morphophysiological characteristics--forms a new genus Gardnerella with only one species G. vaginalis. The bacterium is important for man's pathology, as it is responsible for the most numerous vaginitis, considered nonspecific. The paper reports synthetically the present knowledge in biology, pathogenicity, diagnosis and treatment.

Animals↗

[Periodontal diseases with Entamoeba gingivalis].

At the beginning of our century Entamoeba gingivalis was considered to be a pathogenic bacteria, capable to induce parodontal lesions. Later on it was also found in healthy persons, and the germ was less interesting from the medical view-point. In the present study the authors report their findings concerning E. gingivalis in 135 patients with various stomatological affections including: dental caries, parodontopathies, pulpitis, gangrene, ulcero-necrotic stomatitis etc. The study was started following the discovery of the amoeba in the gingival exsudate of a male aged 19 years with chronic superficial marginal parodontopathy, who, after a treatment with metronidazol, was cured. Entamoeba gingivalis belongs to the Rhizopoda class, together with E. dysenteriae, and E. coli, but, in contrast with these strains it does not have resistance forms (cysts). Oral amoeba were evidenced in 18 out of 78 patients with parodontal lesions (23.07%), in the gingival exsudate, the purulent secretion from parodontal pouches, in the dental tartar, the alveolar fluid following extraction etc. In 117 students from the Faculty of Stomatology, and in 57 patients with various other stomatological affections these germs were not found in any of the abovementioned products. Microscopic examination of fresh preparations, and of Giemsa-stained smears was the main method for the detection of the amoeba. The etiopathogenic role of E. gingivalis is re-examined in discussions regarding certain parodontopathies.

Adult↗

[10 years after the death of Professor Mihai Ciucă (18 July 1883--20 Feb 1969). Mihai Ciucă and the study of bacteriophage, recorded in his working notebooks].

The work records of professor Mihai Ciucă (found in the archives of the Department of Microbiology) give us an insight into his scientific thoughts and practical activity. These documents speak of his dedication to the problem of the bacteriophage started in Jules Bordet's laboratory of the Pasteur Institute in Brussels, in 1920 and continued until 1969, the year in which he died. Since the discovery of the phenomenon of lysogeny, called the Bordet-Ciucă phenomenon, the professor initiated a wide range of research themes on the bacteriophage, guiding and promoting the work of a great number of specialists in the National Center, founded in 1949.

Bacteriology↗

[Studies of oral microbiogenesis. II. Significance of staphylocci present in periodontal lesions, pulp gangrene and in the alveolus after tooth extraction].

A study was carried out on the properties and significance of staphylococci isolated from the alveoli after dental extraction (12 strains), from parodontal pus (19 strains) and pulpar gangrene (15 strains). By their frequency, staphylococci of the Staphylococcus aureus have an etiologic significance in pulpar gangrene. Of particular importance for the diagnosis and epidemiology was the predominance of lysotype 80 among the staphylococci isolated from pulpar gangrene and lysotype 77 in healthy carriers. In 2 of 11 patients the coexistence of the same lysotype was found in the pulpar gangrene and nasal secretion.

Alveolar Process↗