Temporal bone disease in pre-Columbian America.
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Biomedical subjects
Publications and source records attributed to M Schultz.
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Three cases of hard tissue formations of odontogenic origin are presented. The objects were discovered among skeletal finds in prehistoric settlements. The morphology of these objects is described with macroscopical, histological, and radiological methods. All three cases are odontomas. The differential-diagnostic possibilities of these formations, their development and the frequency of their occurrence are discussed. Odontomas are not interpreted as tumors, but rather as malformations and are contrasted to blastomas of odontogenic tissues (e.g. ameloblastoma).
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The problem of 'Gundu' in primates is discussed. Cases of so-called 'Gundu' in the literature, two cases in Gorilla and one in Lagothrix, are dealt with. Histological and X-ray techniques are used. One case (Lagothrix) represents the so-called simian bone disease, which is metabolic disorder and is due to a secondary nutritional hyperparathyroidism. The other two cases (Gorilla) show symmetrical bony tumors of the maxilla. The origin is uncertain. Gundu, Paget's disease and primary hyperparathyroidism Recklinghausen have not been observed in primates so far.
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The isolation of II-S globulin, which is homogenous on sedimentation and gel chromatography (s020, w = II,8 S), from sunflower seeds is achieved by cryoprecipitation from solutions of high ion strength (I approximately 0.5 to 1.8) with simultaneous reduction of the salt concentration (I approximately 0.3) and repeated gel chromatography on Sephadex G-200. By this technique, the 7-S component which occurs in small quantity is isolated too. In solutions of low ion strength (I less than 0,3), the II-S globulin dissociates to give a 7-S component. At high or low pH values (greater than 9.0 and less than 3.0, respectively), the latter dissociates to give a 3-S component, and in the presence of urea it further dissociates to give subunits. In the presence of sodium of sodium chloride, the dissociation of the 3-S component may be inhibited. The various steps of dissociation can be studied by means of ultracentrifugal sedimentation, gel chromatography and gel electrophoresis.
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The presented data suggest that PAPase may, indeed, be important in the biosynthesis of lung phospholipids. The observed increase in the specific activity of rabbit lung precedes the "surge" of phosphatidylcholine concentration and surfactant biosynthesis by at least 24 hours. In human amnionic fluid, PAPase specific activity was markedly increased in pregnancies of 35 weeks of gestation or more. The increase in the specific activity of PAPase preceded the "surge" of acetone precipitated phosphatidylcholine. The reported studies may provide an additional procedure to examine the problems associated with surfactant biosynthesis.
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