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Biomedical subjects

M Schultz

Publications and source records attributed to M Schultz.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Pharmacodynamics of vecuronium in infants during intravenous induction of anesthesia with ketamine].

The pharmacodynamic effects of vecuronium in children aged 1 to 6 years were investigated after intravenous induction of anaesthesia with ketamine, using an initial dose of vecuronium of 0.08 mg/kg body wt. 0.1 mg/kg body wt. The degree of neuromuscular blockade was determined by measuring the contraction force of the m. adductor pollicis after supramaximal stimulation of the ulnar nerve using an electromechanical device. The results (median, chi min and chi max) were as follows. For the initial dose 0.08 mg/kg body wt., the onset time was 150 s (110-360 s); total blockade: 5 of 9 children, D25 (duration of 25% recovery) 13 min (10-31); RI (recovery index): 8.5 min (6.0-14.5); D90 (duration of 90% recovery): 27 min (20-44). For the initial dose of 0.1 mg/kg body wt., the onset time was 135 s (80-300); total blockade: all children, D25: 19.5 min (12-32.5); RI: 8.75 min (6.5-13.5); D90 35 min (22-45). Only the D25 was significantly shorter using an initial dose of 0.08 mg/kg body wt. For a total blockade, a higher dose of vecuronium is necessary using intravenous induction of anaesthesia compared with previously described inhalation techniques. Even with the high dosage, recovery from neuromuscular blockade is so rapid in this age group that it can be used even for short operations without reversal.

Anesthesia, Intravenous↗
PubMed1985

[Hemodynamics and morphologic changes following stroma-free hemoglobin solutions in animal experiments].

Hemodynamics and pathomorphological signs after infusion of a stroma-free hemoglobin solution with defined stroma rest contend were registered in 24 minipigs. The small intravascular persistence and potential toxicity were the disadvantages of the solution. We noted a falling down of the central venous pressure and an ascent of the middle arterial pressure so the total peripheral resistance.

Acid-Base Equilibrium↗
PubMed1985

Explorative studies on karyometric frequency distributions. II. Approximation using normally distributed curves versus median interpolation.

An approximation using normally distributed curves and a median interpolation were applied to frequency distributions of nuclear size with one maximum. Both methods gave the same results as far as the positions of the curves on the axis of nuclear volume classes were concerned. Further detailed information on the course of the curves by the median interpolation, however, may be falsified by artificial differences due to the interpolation.

Animals↗
PubMed1984

The pharmacokinetics of heroin in patients with chronic pain.

We measured blood concentrations of heroin and its active metabolites, 6-acetylmorphine and morphine, serially in 11 patients with chronic pain (9 of whom had cancer) after intravenous injection, intravenous infusion, intramuscular injection, and an oral dose of heroin hydrochloride. Parenteral heroin provided measureable blood levels of heroin, 6-acetylmorphine, and morphine. Blood levels of heroin and 6-acetylmorphine reached their maximal concentrations within minutes and were cleared rapidly. The mean half-life of heroin (+/- S.D.) after intravenous injection or infusion was only 3.0 +/- 1.3 minutes, and the mean clearance of heroin from the blood at apparent steady state was 30.8 +/- 2.1 ml per kilogram of body weight per minute. Morphine levels rose more gradually, and morphine was cleared much more slowly. Oral administration of heroin resulted in measurable blood levels of morphine but not of heroin or 6-acetylmorphine. The amount of circulating morphine provided by an oral dose of heroin was only 79 per cent of that available from an equal amount of morphine. We conclude that heroin is a pro-drug that serves to determine the distribution of its active metabolites. Parenteral heroin is rapidly converted to 6-acetylmorphine, which contributes to rapid pain relief. Oral heroin is converted to morphine and appears to be an inefficient means of providing morphine to the systemic circulation.

Administration, Oral↗
PubMed1984

Problems in fitting a cosine curve.

In fitting of cosine curves latent experimental inequalities due to a serial effect have to be excluded. Though cosinor analysis may be sufficient then, inclusion of biological time, i.e. not fitting values to time but to a function of time, will lead to further improvement.

Animals↗
PubMed1984

[Note on the smoothing of time series].

For smoothing of time series instead of the method introduced by Kulenkampff and Kolb as a simple mathematical procedure weighted moving averages are proposed.

Animals↗
PubMed1983

Karyometric investigation on circadian rhythmic changes in the periportal and perivenous zones of the acinus of the rat liver.

In untreated adult male albino rats changes in nuclear volume within the periportal and the perivenous zones of the liver acinus were measured during a full day and night cycle. Only the perivenous zone displayed circadian rhythmic changes as expressed in the sinus-like course of the nuclear volume-distribution graph (polynomial) with a maximum between 16.00 h and 18.00 h and a minimum at 8.00 h. In all groups studied zonal heterogeneity of the means of nuclear volume and the percent-distribution graphs of nuclear volume classes were retained during the full cycle. Within each zone, however, distribution curves of nuclear volume classes were homogeneous indicating an equally directed trend in time-dependent changes in nuclear volume.

Animals↗
PubMed1983

Evidence from opiate binding studies that heroin acts through its metabolites.

The relative affinity to opiate receptors of heroin, 6-acetylmorphine and morphine was estimated by determining their ability to displace specifically bound 3H-naltrexone from rat brain opiate binding sites. In vitro hydrolysis of heroin to 6-acetylmorphine was monitored in the binding assay filtrate by use of a quantitative HPLC procedure. The rate of heroin hydrolysis was significantly slower at 0 degrees C than at 37 degrees C. The displacement of 1 nM 3H-naltrexone by unlabeled ligand at concentrations ranging from 7 to 500 nM was measured at 0 degrees C for 120 minutes, yielding IC50 values of heroin = 483 nM, 6-acetylmorphine = 73 nM and morphine = 53 nM. When the binding data for heroin were recalculated to include the displacement that could be attributed to the 6-acetylmorphine derived from heroin degradation during the incubation, all of the apparent heroin binding was accounted for by the 6-acetylmorphine. These results are consistent with previous reports of the low binding affinity of morphine congeners (e.g., codeine) that lack a free phenolic 3-hydroxyl group and support the view that heroin is a prodrug which serves to determine the distribution of its intrinsically active metabolites, 6-acetylmorphine and morphine.

Animals↗
PubMed1983

Eclipse of coxsackievirus infectivity: the restrictive event for a non-fusing myogenic cell line.

Coxsackieviruses A2, A5 and B3 did not replicate in L8CL3-U cells (a non-fusing variant of the rat L8 myogenic cell line) although these cells possessed a common receptor for coxsackieviruses A2 and A5, and a different receptor for coxsackievirus B3. The restriction in replication was identified as a block in viral eclipse, since 6 M-LiCl treatment permitted recovery of the coxsackievirus A2 inoculum from L8CL3-U cells after 2 h at 37 degrees C, and the cells could be transfected by viral RNA. Cellular fusion which was induced in L8CL3-U cultures by herpes simplex virus type 1 (HF strain) facilitated coxsackievirus A2 and A5 replication. Differentiating myogenic L8 cells acquired full susceptibility to infection concurrently with the appearance of acetylcholine receptors, the muscle-specific isoenzyme of creatine phosphokinase, prominent myotube formation and the acquired capacity of the cells to eclipse virus.

Animals↗
PubMed1983

The detection and prevalence of reactive and physiologic sclerotic dentin, reparative dentin and dead tracts beneath various types of dental lesions according to tooth surface and age.

The pulpo-dentinal complex responds to external injuries with dentin sclerosis (DS), dead tracts (DT), or reparative dentin (RD). This investigation correlates the prevalence of these responses with age, sex, type and surface location of tooth lesions (caries, restorations, attrition, abrasion and erosion) utilizing ground sections, microradiographs and decalcified paraffin-embedded tooth sections treated with the Pollak trichrome stains (270 teeth from 113 patients). The main response to caries, restorations and erosion was DS, followed by RD and DT. DS, RD and DT occurred equally in any tooth, on any tooth surface and even beneath the same lesion. DS did not necessarily prevent RD. Root and furcation DS and RD in the floor of the pulp chamber and root canals were unrelated to particular lesions but did relate to increasing age. Root DS extended from apical to cervical area with increasing age. Beneath caries and restorations DS and RD were more prevalent in males, but DT was more prevalent in females. Pollak staining of decalcified paraffin sections for DS was approximately 80% as accurate as ground sections and microradiography. In pulp studies, where the result is contrary to previous experience, the Pollak stains reveal whether DS has decreased dentin permeability.

Adolescent↗
PubMed1983

[Regenerative behavior of the human digestive tract under different pathologic conditions. In vitro autoradiographic study].

Tissue samples were obtained by operation on 23 patients with gastric and colonic carcinomas as well as gastric ulcers and polyps in the gastro-intestinal tract. The samples were taken from the pathological area and the "healthy" mucosa, respectively, 2 cm as the standardized distance from the respective place of finding. They were examined by means of in vitro-autoradiography with 3H-thymidine. The marking indiced obtained for benign, and malignant, tumours exceed distinctly the corrected labelled indiced of the normal mucous membrane. The marking values of the mucosa in the histologically inconspicuous vicinity of the carcinoma equal the carcinoma values. In correspondence to autoradiographic investigations by other authors and appropriate biopsy examinations in the neighbouring tumour regions, the in vitro-autoradiography is suggested to have some importance for the diagnosis of tumours.

Autoradiography↗
PubMed1983

[Primary sarcoma of the spleen].

Four cases of sarcoma of the spleen, two fibrosarcomas and two malignant haemangioendotheliomas (mHE), are described. They correspond to an frequency of 0.08% of the post-mortem material. Malignant non-Hodgkin lymphomas of the spleen have not been considered. There are distinct differences between fibrosarcomas and mHE with respect to macroscopic appearance, behavior and formation of metastases. Differential diagnostic problems in the histologic assessment of mHE are discussed.

Aged↗
PubMed1982

Production, characterization and application of protein isolates from shark. Part 3. Characterization of protein isolates.

The functional and nutritional characterization of two isolates elaborated through cleaning-extraction processes, as well as that of a third isolate obtained by means of a chemical modification (alkaline heat treatment) from one of the former, was carried out. The first two isolates exhibit in general similar properties, are nutritionally comparable with casein and show a fairly high water absorption, having a potentially great value for instance in bakery and meat products and pastes. The modified isolate is essentially different from the isolate used as raw material in many of the characterized parameters, having a high nitrogen solubility index (NSI) by pH 3.5 and 7.0 and thus offering its possible use in such food systems as soft drinks where a high solubility is desired.

Amino Acids↗
PubMed1982

[Malformed child following failed termination of pregnancy].

Reported in this paper are findings recorded from a male infant who died eight days from birth, after an attempt of pregnancy termination had failed earlier. Included in these findings were malformation of the vertebral column and bony thorax as well as dorsal meningomyelocele. Intra-uterine manipulation in early pregnancy does not necessarily lead to injury of the foetus and to abortion. Hence, intra-uterine foetal damage should be ruled out by methods of prenatal diagnosis in all cases of continued pregnancy.

Abnormalities, Multiple↗
PubMed1981

Miami TLSO in the management of scoliosis: preliminary results in 100 cases.

A custom fabricated polypropylene thoraco-lumbo-sacral orthosis (TLSO) for the treatment of scoliotic curves with an apical vertebrae of T7 or below is described, and the results in 100 patients treated over a 5 year period are reported. The average follow-up for all cases was 13 months, the longest being 59 months. Average initial correction in brace for thoracic curves was 36%, for thoraco-lumbar curves 56%, and for lumbar curves 63%. Double major curves averaged 38% initial correction for the upper curves and 37% for the lower curves. Twenty cases had completed brace treatment with an average follow-up of 8 months out of brace. Of the 30 curves in the 20 patients, 11 were improved more than 5 degrees, 19 remained unchanged (+5 degrees), and none had progressed more than 5 degrees. Twenty-three percent of the patients required a second orthosis and complications occurred in only two patients. The primary advantages of this TLSO include improved cosmesis, minimal discomfort, excellent provision for heat exchange, minimal confinement of the thoracic cage, and maximum retention of spinal mobility.

Adolescent↗