Biomedical subjects

M Schulein

Publications and source records attributed to M Schulein.

3 recordsLinked to original sources

PubMed2001

Physicians' perceptions of menopause and prescribing practices in Morocco.

OBJECTIVE: To investigate the prescribing practices of Moroccan physicians around menopause. METHODS: A survey was carried out on a representative sample of physicians in the capital city Rabat. The sample included general practitioners, gynecologists, cardiologists and rheumatologists, practicing in both public and private facilities. The instrument consisted of close- and open-ended questions about the socio-demographic characteristics of physicians, their patient population, their prescribing practices, and their perceptions of menopause and the different medical approaches to managing the symptoms and risks associated with it. RESULTS: Most of the physicians interviewed are positively inclined towards the notion of prevention and in favor of hormonal treatment, and approximately half report that they have prescribed hormone therapy. Gynecologists and male physicians prescribe hormones more frequently, as well as physicians who are at private facilities. These findings are discussed in relation to the physicians' perceptions of the menopause transition. CONCLUSION: There are considerable variations in prescribing practices and perceptions of menopause among Moroccan physicians.

Attitude of Health Personnel↗

PubMed1983

Perceived behavioral changes observed with adaptive seating devices and training programs for multihandicapped, developmentally disabled individuals.

The purpose of this study was to assess, by analyzing survey responses, the perceived behavioral changes that were observed when adaptive seating devices and training programs were provided to multihandicapped, developmentally disabled individuals. Results for 41 clients were analyzed. Statistical analysis revealed that significant changes in social interaction, positioning, tracking, grasping, and self-feeding were perceived by parents, guardians, or trainers. The necessity of a prospective study to analyze data about the influence of behavior programs used with adaptive seating devices is discussed.

Adaptation, Psychological↗

PubMed1978

Stoichiometry and specificity of binding of Rauscher oncovirus 10,000-dalton (p10) structural protein to nucleic acids.

A structural protein of Rauscher oncovirus of about 8,000 to 10,000 daltons (p10), encoded by the gag gene, has been purified in high yield to apparent homogeneity by a simple three-step procedure. The purified protein was highly basic, with an isoelectric point of more than 9.0, and its immunological antigenicity was chiefly group specific. A distinctive property of the protein was the binding to nucleic acids. The stoichiometry of p10 binding to Rauscher virus RNA was analyzed using both 125I-labeled p10 and 3H-labeled RNA. The protein-RNA complex, cross-linked by formaldehyde, was separated from free RNA and free protein by velocity sedimentation and density gradient centrifugation. A maximum of about 140 mol of p10 was bound per mol of 35S RNA, or about one molecule of p10 per 70 nucleotides. This protein-RNA complex banded at a density of about 1.55 g/ml. The number of nucleic acid sites bound and the affinity of p10 binding differed significantly among the other polynucleotides tested. The protein bound to both RNA and DNA with a preference for single-stranded molecules. Rauscher virus RNA and single-stranded phage fd DNA contained the highest number of binding sites. Binding to fd DNA was saturated with about 30 mol of p10 per mol of fd DNA, an average of about one p10 molecule per 180 nucleotides. The apparent binding constant was 7.3 X 10(7) M(-1). The properties of the p10 place it in a category with other nucleic acid binding proteins that achieve a greater binding density on single-stranded than on double-stranded molecules and appear to act by facilitating changes in polynucleotide conformation.

Binding Sites↗