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Biomedical subjects

M Schrader

Publications and source records attributed to M Schrader.

At least 145 records · Page 8Linked to original sources
PubMed1987

[A morphological study of the peri- and epineurium in the compression zone of the median nerve in carpal tunnel syndrome].

The structure of the peri- and epineurium of the median nerve in the carpal tunnel syndrome was studied by light and transmission electron microscopy. Electron microscopy confirms the flattened lamellar arrangement of the perineurial cells, but in contrast to the normal architecture the perineurial component of the median nerve in carpal tunnel syndrome consists of 20-25 layers of ramified squamous-type cells, each layer being separated from the adjacent one by a wide space containing thick bundles of collagen fibrils. The perineurial cells are bounded on both sides by a basement membrane which is of substantial thickness. A prominent feature is the occurrence of multiple pinocytotic vesicles and caveolae opening on both the internal and external aspects of the flattened cells. They also contain bundles of closely aggregated filaments. In the spaces between the perineurial cells we find, in some places, extremely disoriented and individually abnormal fibrils and fine filaments arranged in form of a spider web. Matrix vesicles can also be seen. The epineurium of the median nerve in the carpal tunnel syndrome is also considerably thickened, and the attachment is solid, so that the median nerve is relatively immobile constricted like an hourglass. The thick collagen fibers are orientated predominantly parallel to the axis of the nerve, but circular fibers can also be seen. Apart from fibroblasts, the outer layer of the epineurium contains mast cells and vasa nervorum as well as myelinated nervi nervorum. Variable quantities of fat are also present, particularly in the surrounding loose connective tissue.

Carpal Tunnel Syndrome↗
PubMed1986

[Results of comparative studies of Strömbeck and Skoog breast reduction-plasty].

Long-term results in reduction mammaplasty can be evaluated at the earliest after one year. Criticism about the result induced us to apply more often the technique of Skoog beside the procedure of Strömbeck. A follow-up study of 110 patients could be done. Objective parameters were considered as well as subjective factors. Special attention was paid to diagnosis of cancer after mammaplasty.

Breast↗
PubMed1985

[Nuclear spin tomography of the petrous bone and cerebellopontiLe angle. Methods and normal anatomy].

Proton nuclear resonance tomography, also called magnetic resonance imaging, is a new imaging procedure which makes it possible to obtain tomographic cuts of the petrous bone in three planes. It is complementary to CT and is able to demonstrate the small structures of the inner ear and of the cerebello-pontine angle, without bone artefacts and without overlap or distortion. By using special surface coils combined with thin sections and a gradient-zoom technique, it is possible to obtain high resolution images which equal those of modern CT. By choosing suitable exposure parameters and a multi-echo technique, one can obtain excellent tissue contrast without using positive or negative contrast media.

Cerebellopontine Angle↗
PubMed1985

[Proton spin tomography in diseases in the petrous bone region].

Magnetic resonance tomography (MRI = magnetic resonance imaging) can provide sectional images of the petrous bones in all planes. It is complementary to computed tomography (CT) and can demonstrate inflammatory changes in the petrous bones and mastoids, and cholesteatomas, with accuracy and without artifacts. MRI is inferior to CT for the demonstration of bone destruction and this this limits its use in the diagnosis of glomus tumours. The use of special surface coils combined with thin sections and a gradient-zoom technique provides high resolution images which approach the quality of modern CT examinations. This opens new possibilities for the diagnosis of small acoustic neuromas; because of the excellent tissue contrast, they can be well demonstrated without using intravenous contrast media or intrathecal air (CT-air meatography).

Adult↗
PubMed1985

[Differential diagnosis, operative procedure and prognosis in complicated syndactylies].

Two cases of congenital syndactyly of all fingers are presented. Special anatomical abnormalities found during the operations are discussed. The correlation with an anatomically and ontogenetically well-founded classification provides knowledge for use in the individual case which may be helpful in selecting the proper surgical procedure, in establishing a schedule, and in providing the prognosis.

Hand↗
PubMed1985

[Subglottic plasmacytoma: diagnosis and prognosis].

A subglottic primary extramedullary plasmacytoma (typ IgA-Lambda) of the larynx is reported. These tumours are very rare. The diagnosis is made more difficult by unspecific symptoms and can only be confirmed by histopathology. Early diagnosis and differentiation between primary extramedullary plasmacytoma and metastasis from a multiple myeloma are very important for the prognosis of the disease. Whether immunology can help to solve this problem is still doubtful: few cases have so far been examined by this method. Paraproteins are often not secreted in extramedullary plasmacytoma; the peroxidase-anti-peroxidase method is therefore helpful for classification of the tumour.

Aged↗
PubMed1985

[Long-term experiences in plastic surgery treatment of radiation damage].

Over a period of 22 years the authors reconstructed 49 patients with radiation injuries of varying severity. The retrospective study examined the indications for the radiation therapy, the interval between the treatment and the development of tissue damage, its site and severity. A few typical case reports are presented. Particular aspects emerging from this series, the reconstructive methods used and the results achieved with regard to partial or complete excision of radiation damaged skin are discussed.

Adolescent↗
PubMed1984

[Plastic surgery reconstruction of late sequelae following burns of the hands].

Late consequences of burns of the hands can be divided into four types depending on their extent and the involvement of the underlying tissue structures. Of 88 hands operated on, 43% were Type I, 28% were type II, 25% were type III, and only 4% belonged to the mutilating type IV. Clinical examples of types I and III are shown. Type I requires operation on the skin only to restore full function of the hand, whereas type III also needs repeated surgical treatment of the dorsal apparatus, tendons, ligaments and joints to improve hand movement.

Adolescent↗
PubMed1983

In vivo induction of neoplastic growth in nude mouse connective tissue adjacent to xenografted human tumors.

Induction of neoplastic growth of murine stroma cells within the human tumor xenograft was observed after serial passage of CEA and beta 2-microglobulin producing human colonic SLu tumor xenografts in nu/nu BALB/c mice. Mouse tumors within the human tumor xenografts were identified using specific immunohistologic staining techniques for mouse histocompatibility marker or human CEA. These mixed tumors could be distinguished from normal human tumor xenografts by a different relationship between development of the tumor marker in the serum and tumor size. We were able to establish transformed murine cells from human xenografts, either induced by SC injection of 1 X 10(6) tumor cells of the SLu cell line or by human SLu or mammary carcinoma tissue serially passaged in athymic animals. The established human and murine cell lines were characterized by cytogenetic methods. Transformed murine cells were then continuously passaged in tissue culture. The transformed mouse fibroblasts proved to possess tumorigenicity in nude mice. In the case of SLu-derived mouse tumor cells, tumors also developed in the immunocompetent BALB/c mice using 1 X 10(6) to 5 X 10(6) tumor cells for SC transplantation.

Adenocarcinoma↗
PubMed1980

[Late results of shape-improving and shape-preserving mammaplasties: indication and selection of procedure (author's transl)].

Results of shape-improving and shape-preserving operations to a woman's breast and the quality of the operation method cannot be assessed until a number of years later. Subsequent processes entailing alteration in the structure of the skin and subcutaneous tissue, gliding down of gland tissue to Mm. pectoralis, broadening of vertical scars, and complications to the remaining gland tissue may basically vary the results obtained. Late results and view points leading to the selection of procedure will be discussed and compared with those in the literature.

Adult↗
PubMed1980

[Malformation syndrome with constriction rings, pseudoligaments, acral defects and syndactylism: diagnosis and treatment (author's transl)].

Congenital constricting bands of the extremities, pseudo-ligaments, distal defects of fingers and syndacatyly are all characteristic marks of this syndrome. At least two of the features must be present to make the diagnosis. The authors' results are reported and experience in paediatric hand surgery is essential. This should be performed as early as possible. Operative techniques are described.

Abnormalities, Multiple↗
PubMed1980

[Mamma augmentation with homoeoplastic fatty tissue. Long term observations (author's transl)].

The report covers three cases of mamma augmentation with homoeoplastic fatty tissue, performed elsewhere. The defence reaction takes a three-phase course: 1st Phase: Clinically asymptomatic, with autolysis and capsule formation (1 to 8 years), 2nd Phase: intermittant complaints, hardening of the mammae and enlargement of lymph nodes (after 4 to 91/4 years), 3rd Phase: Acute mastitis (after 5 to 91/4 years). The long-term developments show that mamma augmentation with homoeplastic fatty tissue is a method which is detrimental to health.

Adipose Tissue↗
PubMedDate not supplied

The membrane fatty acid-binding protein is not identical to mitochondrial glutamic oxaloacetic transaminase (mGOT).

For evaluation whether the membrane fatty acid-binding protein is related to mGOT, studies on the structure and function of both purified proteins were performed. Physicochemical characterization revealed that both proteins are different: the membrane fatty acid-binding protein has a molecular weight of 40 kD and a pI of 8.5-9.0, whereas rat mGOT has a molecular weight of 44 kD and a pI of 9.5-10.0. According to this distinct differences, they migrated separately on 2-dimensional electrophoresis. Furthermore, monospecific antibodies against the membrane fatty acid binding protein did not react with rat mGOT. In co-chromatography studies only the membrane fatty acid-binding protein showed affinity for long chain fatty acids, but not mGOT. Moreover, membrane binding studies were performed with the monospecific antibody to the membrane fatty acid binding protein. The inhibitory effect of this antibody on plasma membrane binding of oleate was reversed after preabsorption of the antibody with the membrane fatty acid binding protein, but was not affected after preabsorption with mGOT. These results indicate that the membrane fatty acid binding protein and mGOT are structurally and functionally not related. The data also support the significance of this membrane protein in the plasma membrane binding process of long chain fatty acids.

Animals↗