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Biomedical subjects

M Schiff

Publications and source records attributed to M Schiff.

At least 73 records · Page 4Linked to original sources
PubMed1981

Secondary ureteropyelostomy in renal transplant recipients.

Ischemic necrosis of the allograft ureter after renal transplantation most often results from failure to preserve adequately is vascularity during donor nephrectomy. An acute episode of rejection occurring within the first few weeks postoperatively may serve to compound the problem, producing even more extensive necrosis of the urinary collecting system. Secondary ureteropyelostomy using the recipient's own ipsilateral ureter is the salvage operation of choice in this situation and can be highly successful provided there is strict adherence to a number of important surgical principles.

Graft Rejection↗
PubMed1981

Testicular tumors in 2 families.

Testicular cancers in closely related family members are rare. We herein report the second incidence of pure seminoma occurring in a father and son. The increased risk of malignant tumors developing in the undescended testis is well established. We also describe the second reported incidence of testicular cancers occurring in 2 non-twin brothers, in which 1 of the cancers developed in an undescended testis.

Adult↗
PubMed1981

Adaptive immunity of the tympanic membrane.

In a previous experiment an antiserum was developed in the rabbit from the lamina propria of the tympanic membrane of the guinea pig. In the present study 18 Hartley guinea pigs were used in an in vivo experiment in which the antiserum (RAGTM IgG) served passively to immunize the animals subjected to various forms of trauma to the right tympanic membrane. Two groups (18 animals) immunized with normal rabbit IgG or normal saline served as controls. The left tympanic membrane remained untouched in all groups and served as an internal control. Various forms of trauma (infection, cauterization, section), various times (one to 21 days), and diverse techniques of staining (immunofluorescence, complement, and immunoperoxidase) were studied. The results indicate that the combination of trauma and sensitization in the first group evokes a particular response in the lamina propria of the tympanic membrane in immunized animals (RAGTM IgG). The form of trauma does not influence the results, but time seems to be an important factor. This work addresses several questions concerning the possible role of the combination of trauma and sensitization in conditions that involve the tympanic membrane and middle ear clinically.

Animals↗
PubMed1980

Immune response of guinea pig tympanic membrane.

The authors present the results of their experiment on the immune response of the guinea pig tympanic membrane. The first step was to develop an antiserum in the rabbit from the guinea pig tympanic membrane (RAGPTM). The lamina propria was used and IgG was identified as the main constituent of this antiserum. In their initial experiment, the RAGPTM IgG seemed to be specific to the acellular connective tissues of the respiratory tract and TM. The experiment presented here is concerned with the immune response of the guinea pig tympanic membrane. The animals were sensitized by intracardiac injection with the antiserum, and within one hour the right TM was traumatized in diverse fashions (bacteriological, chemical, mechanical traumas). The left TM served as a negative control. Animals were sacrificed at 24 hours, 7 days and 21 days. Immunofluorescence staining, complement studies (C23) and immunoperoxidase techniques were used on the TM. It appears that the GPTM can be antigenic in the rabbit. The right TMs of the sensitized guinea pigs reacted differently in the sense that there seems to be homing of the RAGPTM IgG to the site of trauma and that the complement participates in the reaction at least in the first week. The lamina propria of the TM is the site of the immune response. This work will need more elaborate studies but allows us to address different questions concerning the possible role of the combination of trauma and sensitization in conditions clinically involving the TM and middle ear.

Animals↗
PubMed1980

Experience with the use of an intravesical hydrostatic pressure balloon.

Treatment with the use of an intravesical hydrostatic pressure balloon has been undertaken on 34 occasions in 24 patients. The procedure can be of great benefit in seriously ill patients with intractable hemorrhage of the bladder in whom alternative treatment methods either have failed or are too great a risk to attempt. It can also provide a useful treatment adjunct in the management of patients with massive low grade, noninvasive tumors of the bladder in whom endoscopic resection is not technically possible.

Cystitis↗
PubMed1980

Control of breathing in asthma.

The hyperventilation seen in asthma is due to an increase in respiratory drive. This may be reflected by increased neural output to the respiratory muscles and probably by alterations in the respiratory pattern. This increased respiratory drive is most likely in response to irritant receptor stimulation in the lung. Our understanding of the genesis of hyperventilation and an abnormal breathing pattern in asthma has paralleled in growth in our understanding of the mechanism of respiratory control. New methods for studying the control of respiration have been applied to the clinical problem of asthma successfully. Further growth in the applications of knowledge of respiratory control may be expected.

Airway Resistance↗
PubMed1979

Results of biopsy after early stage prostatic cancer treatment by implantation of 125I seeds.

We have treated 77 patients for clinically early stage carcinoma of the prostate, 9 stage A2, 63 stage B and 5 stage C, with direct implantation of 125I seeds into the prostate and pelvic lymphadenectomy. It is estimated that a minimum dose of 15,000 rad but a maximum dose of 35,000 rad is delivered to the prostate over several months. Of the 77 patients 14 (18 per cent) had metastatic disease in the pelvic lymph nodes. In 22 cases perineal needle biopsy was done 12 to 18 months after treatment and in 3 cases a second biopsy was performed after 2 to 3 years. Persistent tumor was present in 11 biopsies. Cytological changes were observed in 8 of these, primarily cytoplasmic vacuolation and nuclear pyknosis. There seemed to be no relationship between grade and stage of disease and histological evidence of persistence of tumor after radiation. One patient with persistent tumor in the postoperative biopsy has shown progression of disease after 2 years and another with a negative biopsy has a bony metastasis. The remaining 10 patients with persistent tumor have shown no sign of progression of disease during a 2 to 4-year interval.

Biopsy, Needle↗
PubMed1979

Treatment of solitary and bilateral renal carcinomas.

Recent experience with 7 patients, as well as a review of the literature, indicates that partial nephrectomy provides satisfactory treatment of solitary and bilateral renal adenocarcinomas. Patient survival seems to be dependent on the adequacy of tumor resection and not on the fate of the contralateral kidney. Total nephrectomy, dialysis and subsequent transplantation are viable alternatives when it is technically not possible to preserve adequate renal parenchyma.

Adenocarcinoma↗