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Biomedical subjects

M Schürer

Publications and source records attributed to M Schürer.

25 records · Page 2Linked to original sources
PubMed1984

[Studies and results of the use of nuclear medicine methods in kidney function tests].

It is sought for alternative methods for the endogenous creatinine clearance as parameters for the GFR. For this purpose served investigations with Tc-99m-Sn-DTPA. It was found a good reproducibility for the slope clearance with 3 blood takings between 60 and 120 minutes. When combined with the camera function scintigraphy a side-separated quantitative statement of the clearance equivalent is possible. The inulin clearance serves as reference method. The investigations at the gamma-camera with Tc-99m-Sn-DTPA also allow the determination of the perfusion which is particularly of interest in patients with hypertension. According to the comparison at the gamma camera a diagnostic schema is recommended.

Adult↗
PubMed1983

[A method for the cryopreservation of thrombocytes].

By using dimethylsulfoxide (0.7 mol/l) a technique of cryoconservation of thrombocyte concentrates was elaborated, with own material-technological possibilities being taken into consideration. In comparison to fresh thrombocytes the results of parameters tested in vitro reveal a mean functional ability of 50%. The survival time of cells stored in this way in vivo may be compared with fresh cells. On this basis HLA-typed single-donor pools could be established for clinical application.

Blood Platelets↗
PubMed1983

[Suitability of bone scintigraphy for the determination of bone reaction or regeneration following endosseous implantation of alloplastic materials with special reference to bioactive materials].

A programme for the investigation of the behaviour of bioactive and bioinactive implant materials by the osseous bed was enlarged by the scanning. This one allows a follow-up of bone processes in vivo. The implants were inserted into the patellar surface of the right and left femur of rabbits. The bone regeneration after defect formation without implant serves as standard of comparison. The scintigrams were taked down with 99m-Tc-EHDP. The bone scanning provides differentiate statements about the temporal process incorporation. Its non-specificity allows no separation between the behaviour of bioactive and bioinactive materials in biologic surroundings. The scintigraphic findings can be interpreted below employment of the results of the other tests and previously known material qualities.

Animals↗
PubMed1982

[Relation between the density and maturity of red blood cells in the perinatal period in the rat].

Relations between 59Fe incorporation into red blood cells (rbc) and their density was examined in rats during ontogenesis (20th, 21st, 22nd gestational day, 1st, 21st day of life, adults). The incorporation of 59Fe in rbc of different density was measured 24 or 96 h after application. The density separation was carried out by centrifugation of rbc in phthalate esters of known density. The density of rbc increased during ontogenesis (median density 1.093 kg/l on the 20th gestational day and 1.102 kg/l in adult rats). The erythropoietic activity, in terms of 59Fe-incorporation into peripheral rbc, is higher in newborn rats (60-70%) than in adults (30-50%). 59Fe incorporation into pregnant rats and their fetuses is similar to adult nonpregnant rats. In fetuses a relatively high incorporation of 59Fe was found in comparison to their mother. The relationship between density and maturity of rbc is postnatally more evident than in the prenatal period. (59Fe enrichment in cells of low density prenatally: 2.6 +/- 0.5, postnatally: 8.4 +/- 0.5 (1st day of life), 5.8 +/- 0.8 (21st day of life) 28.5 +/- 5.6 (adult male rats). These findings may reflect a simultaneous formation of rbc at different sites or different clonal origin during prenatal period of ontogenesis.

Age Factors↗
PubMed1982

[Effect of hypoxia on the relationship of density and maturity of erythrocytes of newborn, young and adult rats].

Adult male, juvenile and pregnant rats were exposed to repeated hypoxia 8 h daily for 3-9 days in a low pressure chamber (altitude of 5000 m, pO2 = 11.3 kPa and 6000 m, respectively, pO2 = 9.89 kPa). The density distribution curves of the red blood cells (RBC) and the incorporation of 59Fe into cells of different density were determined. In the ontogenesis the density of RBC increases (median density on the first day of life 1.100 kg/l; on the 21st day of life 1.102 kg/l, adult rats 1.103 kg/l). The density difference between the 1st and 4th quartile in which 50% of the cells range was 0.010 kg/l for newborn and juvenile animals and 0.004 kg/l for adult ones. Exposure to hypoxia led iN the animals of the investigated age groups to a rise of the proporborns, 0.004 for juveniles, and 0.002 kg/l for adult rats. The cumulative distribution curves of 59Fe incorporation and density of RBC can be described by the equation (formula: see text). The value alpha characterizes the relation between density, on the one hand, and the maturity and age of cells, on the other. For control and hypoxic animals the following values for alpha have been calculated: for newborns 0.515 and 0.520, for juveniles 0.829 and 0.596 (p less than or equal to 0.01), and for adult rats 0.875 and 0.823. Juvenile animals from in regard to density similar heterogenic cells as newborns after hypoxia. It may be that ontogenetically older cell forming sites or clones are reactivated.

Aging↗
PubMed1980

[Intraoperative detection of parathyroid tissue by semiconductor electrodes (author's transl)].

With miniature semiconductor electrodes of high sensitivity and special shape it is possible to charakterize diverse tissues during operation. The measured radioactivity of phosphorus reflects its enrichment and storage in the parathyroid tissue. The findings of 5 patients in whom clinically hyperparathyroidism was strongly suspected and who underwent surgery are reported. We have successfully localized parathyroidea adenomas in 3 patients, in 2 cases no adenoma could be found the storage of phosphorus 32 was normal. In all measurements we achieved a complete agreement with histological findings.

Adenoma↗