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Biomedical subjects

M Savoldelli

Publications and source records attributed to M Savoldelli.

82 records · Page 5Linked to original sources
PubMed1977

[Ultrastructural study of a case of molluscum contagiosum (author's transl)].

This is the case of a female child with molluscum contagiosum widely disseminated around the mouth and the eye-lids. Antibiotics were used to stop local staphylococcal superinfection. Follicular conjunctivitis and keratitis punctata disappeared only after complete removal of all cutaneous lesions. Biological diagnosis was done by direct observation of the Poxvirus with the electron microscope, since isolation of the virus itself is impossible. Ultrastructural study of the excised tumor has shown the different stages of the growth of the virus, and the associated cellular lesions.

Child, Preschool↗
PubMedDate not supplied

[Bilateral hereditary corneal dermoid (author's transl)].

The opportunity to follow the descendants of a family carrying the defect of a bilateral corneal lesion already described in the literature has led the authors to recommend surgical treatment and the lesions have been studied by light and electron microscopy. The two diagnoses are discussed: scleocornea and dermoid. They retain the latter diagnosis and give their reasons.

Adult↗
PubMedDate not supplied

Damage to the corneal endothelium by minus power anterior chamber intraocular lenses.

We present 16 phakic myopic eyes (from -10.00 to -25.00 diopters) corrected by minus power intraocular lenses implanted in the anterior chamber whose corneal endothelium was observed by specular microscopy during a postoperative period from 6 to 18 months. Significant morphologic endothelial changes were noted in three eyes along the border of the lens optic. Around dark zones, which appeared acellular, endothelial cells were enlarged, deformed, and separated. These findings may be produced by intermittent contact between the endothelium and lens. Corneal indentation during specular microscopy occasionally caused a curvilinear reflection which corresponded to the optic border. In three eyes, dark areas without cellular abnormality were observed near the curved edge of the lens. These findings probably resulted from the disturbance of the specular reflection on part of the endothelium due to this edge.

Anterior Chamber↗
PubMedDate not supplied

Corneal wound healing in monkeys 18 months after excimer laser photorefractive keratectomy.

Excimer laser keratomileusis (photorefractive keratectomy, direct corneal ablation) for myopic corrections of 2.00 diopters (n = 1), 4.00 D (n = 4), and 8.00 D (n = 3) was performed on eight corneas of four Rhesus monkeys. All animals were followed for 18 months. The ablations healed normally and no epithelial erosions occurred. Serial slit-lamp microscope examinations revealed that a variable amount of corneal haze developed in all animals; this haze progressively faded during the follow-up period. Histopathology revealed an epithelium of normal thickness, basement membrane abnormalities, increased number and activity of stromal keratocytes, and a variable amount of newly secreted extracellular matrix in the anterior stroma. These findings suggest that excimer laser keratomileusis induces a mild wound healing response in the anterior cornea which displays considerable individual variability and persists up to 18 months.

Animals↗
PubMedDate not supplied

[Trephination using an Excimer laser].

We compared histologically and ultrastructurally donor buttons and recipient beds trephined mechanically with those trephined by the Excimer laser at 193 nm. The laser allowed for superior cutting precision and perfect centering. This non-contact method obviated the need for any pressure or suction during trephination, thereby eliminating problems associated with distortion of corneal topography. We studied wound healing after penetrating keratoplasty with mechanical and laser trephination in an animal model. The laser did not adversely affect wound healing processes.

Animals↗