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Biomedical subjects

M Satoh

Publications and source records attributed to M Satoh.

At least 1,045 records · Page 58Linked to original sources
PubMed1986

A case of idiopathic sustained ventricular tachycardia of about 70 days' duration.

A 29-year-old woman with idiopathic sustained ventricular tachycardia (VT) of about 70 days' duration who was in congestive heart failure is described. VT showing QRS morphologic pattern of right bundle branch block and left axis deviation during an episode of tachycardia is suggested to make a unique clinical entity; (1) it occurred in young and asymptomatic adults without demonstrable organic heart disease; (2) the VT was inducted and terminated with atrial or ventricular stimulation; and (3) it responded to verapamil.

Adult↗
PubMed1986

Communication between epidural hematoma and cephalhematoma in a neonate.

A case of neonatal epidural hematoma caused by falling at a premature delivery is presented. It accompanied a cephalhematoma communicating to the epidural hematoma through a fracture of the skull. The mechanism of this peculiar form of neonatal epidural hematoma is discussed.

Birth Injuries↗
PubMed1986

Endogenous production of TNF in mice with immune complex as a primer.

C3H/He mice were immunized i.v. with sheep red blood cells (SRBC), and then the effect of i.v. challenge with SRBC on the priming of endogenous production of tumor necrosis factor (TNF) was investigated. Mice were immunized i.v. with 10(8) SRBC/mouse, and their serum TNF activity, triggered by 3 micrograms lipopolysaccharide (LPS) per mouse, was assayed by an in vitro cytotoxicity test using L-929 cells. Anti-SRBC antibodies were induced maximally in 2 weeks, but the acquired immunity did not affect TNF triggering. However, 9-10 weeks after the primary challenge, when there was still a relatively high antibody titer in the serum, i.v. rechallenge with 10(8) SRBC/mouse transiently enhanced the TNF activity triggered by LPS to about 10 times that in normal control mice. This priming effect of SRBC challenge was antigen specific, because challenge with horse red blood cells (HRBC) had no effect. SRBC opsonized with anti-treated with anti-SRBC antiserum or sonicated SRBC had no effect. These findings suggest two ways of facilitating the triggering of endogenous TNF production: booster challenge of immunized animals with the corresponding antigens makes them ready for TNF triggering, and direct injection of immune complexes, even into normal animals, makes them ready for triggering of TNF. The possible application of these findings for inducing endogenous TNF production in human cancer patients by use of immune complexes is discussed.

Animals↗
PubMed1986

[A case of intracranial amelanotic melanoma].

Malignant melanoma is usually black in color because of the existence of melanin pigments in it. Differing from such a usual melanoma, amelanotic melanoma, which has no melanin pigments and is not black-colored, is rarely described in literature. In this report, a case of intracranial amelanotic melanoma of unknown origin is presented and discussed. This represents the seventh case report of an intracranial amelanotic melanoma. On May 28, 1984, a 55-year-old man was admitted to our department because of repeated left hemiconvulsion. Neurological and physical examination disclosed left hemiparesis, poor concentration and right inguinal tumors. CT scan revealed a right posterior frontal mass with ring like enhancement. On June 7, the patient underwent craniotomy. The brain tumor, partly emerged from right frontal lobe, was reddish and easy to bleed. Macroscopically there were no abnormal findings over leptomeniges. The right inguial tumors, that were lymph nodes, were also removed simultaneously. Microscopic interpretation at that time was that of a malignant tumor of ectodermal origin. Although no melanin pigments were demonstrated in any specimens except for a part of lymph nodes, dopa reaction was positive in both specimens from the brain tumor and the inguial lymph nodes, strongly suggesting amelanotic melanoma. Postoperative course was uneventful, but CT scan of Aug. 31 again showed multiple intracerebral enhanced lesion and ventricular hemorrhage. Aphasia, right hemiparesis and consciousness disturbance developed gradually, and he died on Sept. 21, 1984. Autopsy demonstrated multiple intracerebral hematomas, containing much tumor cells in lung, thyroid and subcutaneous tissue. Primary lesion remained unknown in spite of an extensive examination in autopsy.(ABSTRACT TRUNCATED AT 250 WORDS)

Brain↗
PubMed1985

Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn.

To investigate pre-synaptic influence of the descending noradrenergic system on the primary afferents containing substance P (SP), effects of noradrenergic manipulations on the in situ release of immunoreactive SP (iSP) from the dorsal horn were examined in the thalamic rabbit. Local application of noradrenaline (10 microM) to the dorsal horn produced complete inhibition of the noxious mechanical stimuli-evoked release of iSP. This effect was reversed by yohimbine (the more selective alpha 2-blocker, 10 microM) and partially antagonized by prazosin (the more selective alpha 1-blocker, 10 microM). The resting release of iSP was not affected by noradrenaline. The noxious mechanical stimuli-evoked release of iSP was significantly increased by acute spinal transection and local application of yohimbine (10 microM) alone to the dorsal horn. Prazosin (10 microM) slightly increased the evoked iSP release, and a beta-blocker metoprolol did not affect it. These results suggest that the nociceptive primary afferents containing SP are tonically inhibited by the descending noradrenergic system linked to alpha-adrenoceptors, and that such alpha-adrenoceptors located on the primary afferent terminals may be one of the sites of action of noradrenaline spinal analgesia. In contrast to the evoked iSP release, the resting iSP release was increased only by acute spinal transection and not by yohimbine, prazosin and metoprolol. All these observations suggest that tonic inhibition in propriospinal neurons containing SP is mediated by a non-noradrenergic system.

Adrenergic Fibers↗
PubMed1985

Multiple forms of immunoreactive renin in human pituitary tissue.

Immunoreactive renin was demonstrated in pituitary tissues of postmortem human subjects with different diseases. The specific immunoreactive renin activity comprised the majority of the tissue renin-like activity (mean, 83%), indicating the absence of nonspecific actions of proteases such as cathepsin D. We used three pituitary specimens with high levels of the specific renin activity for further biochemical characterization of the enzyme. Small differences were found in the molecular mass (45 K, 42 K and 37 K), binding to concanavalin A-Sepharose, and isoelectric points (pI) (4.72, 4.78, 4.86, 5.06, 5.28 and 5.44). These results seem to be interpreted as evidence for the presence of specific renin in the human pituitary with microheterogeneity.

Chromatography, Affinity↗
PubMed1985

Pertussis toxin inhibits intracellular pH changes in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine.

Changes of intracellular pH in human neutrophils were monitored by 9-aminoacridine fluorescence. Both initial acidification and subsequent alkalinization phases induced by a chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine were dependent on the extracellular Ca2+-concentrations, and a calcium ionophore, A-23187 similarly induced the pH-changes. Pertussis toxin inhibited the pH-changes induced by the peptide while cholera toxin did not. The pH-changes induced by A-23187 were not affected by the toxins. The results suggest that the inhibitory guanine-nucleotide regulatory protein and Ca2+ are involved in the pH-changes induced by the peptide.

Adult↗
PubMed1985

Analgesic effects of cyclazocine and morphine microinjected into the rat dorsomedial hypothalamus demonstrated by the bradykinin-induced flexor reflex test.

The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morphine into the same portion also produced a dose-dependent analgesic effect (ED50 2.5 micrograms/rat). As naloxone (0.9 mg/kg s.c.) antagonized both these analgesic effects, the findings suggest that the dorsal portion of the medial hypothalamic area of the rat is one of the primary target sites of analgesic drugs.

Animals↗
PubMed1985

Antinociceptive effects of intrathecal opioids, noradrenaline and serotonin in rats: mechanical and thermal algesic tests.

Antinociceptive effects of intrathecal injections of morphine, methionine-enkephalin, noradrenaline and serotonin were examined in rats, using 3 different methods: the tail-pinch, hot-plate and tail-flick tests. The order of sensitivity of the 3 methods to noradrenaline in the production of antinociception was tail-pinch greater than tail-flick greater than hot-plate, while that of morphine, methionine-enkephalin and serotonin was tail-flick greater than hot-plate greater than tail-pinch. These results indicate that intrathecal noradrenaline, but not methionine-enkephalin and serotonin, produces more potent inhibition of the mechanical nociception than does the thermal one, and suggest a closer relationship of the descending noradrenergic system to the mechanical nociceptive system, in the spinal cord of rats.

Analgesics↗
PubMed1985

Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn.

Effects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined. Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively. Innocuous stimuli did not affect the release of these peptides. These results suggest that the nociceptive mechanical or thermal primary afferents contain substance P or somatostatin, respectively.

Animals↗