Search PubMed⌕ Search

Biomedical subjects

M Saruk

Publications and source records attributed to M Saruk.

9 recordsLinked to original sources
PubMed2000

Immunoperoxidase technique for detecting spirochetes in tissue sections: comparison with other methods.

BACKGROUND: With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy, the incidence of syphilis has been increasing. Given the fact that the above conditions may mask or obscure the usual clinical signs and symptoms of syphilis, a means of enhanced detection is essential. AIMS METHODS: The purpose of this study was to determine whether an immunoperoxidase method using an antibody against treponemes would increase the sensitivity and specificity of diagnosis in biopsies of patients with secondary syphilis. This was compared to serology and silver stain in cases of known syphilis. RESULTS: Immunoperoxidase for treponemes was at least as sensitive (9/10) as pathology (9/10), and more sensitive than conventional silver stain (6/10) or serology (7/10). CONCLUSIONS: In those equivocal cases of secondary syphilis, where confirmation is essential, immunoperoxidase for treponemes may be a useful adjunct.

AIDS-Related Opportunistic Infections↗
PubMed1997

Cutaneous necrosis associated with recombinant interferon injection. Report of three cases with interferon beta-1b and review of the literature.

Interferons are cytokines produced by cells in response to stimulation by certain antigens and infectious agents. In recent years, recombinant interferons have been developed, which have antiviral, antiproliferative, and immunomodulatory functions. Several cutaneous reactions have been reported, including cutaneous ulceration at injection sites. We now report three cases of cutaneous ulceration caused by interferon beta-1b injections. In addition, we review all of the previously reported cases of cutaneous ulceration caused by recombinant interferons and discuss the different mechanisms by which these substances may produce this effect.

Adjuvants, Immunologic↗
PubMed1983

Acrokeratoelastoidosis.

Acrokeratoelastoidosis is a very rare entity of unknown etiology, characterized by small, firm, yellowish, translucent papules which usually appear on the margins of the hands and feet between the junction of the dorsal and palmar/plantar skin. Histologically, the most characteristic features are hyperkeratosis, mild acanthosis, and, most strikingly, fragmentation of coarse elastic fibers within the reticular dermis. This eruption is variable in terms of its onset, may be sporadic or familial, is generally asymptomatic, and has a prolonged course.

Acantholysis↗
PubMed1979

Carcinoma of gallbladder simulating metastatic prostatic cancer.

This is a case of carcinoma of the gallbladder, which clinically, chemically, and radiographically simulated metastatic prostate cancer. Other causes of elevated serum and bone marrow acid phosphatase and axial skeletal osteoblastic metastases are reviewed.

Acid Phosphatase↗
PubMed1977

Aortic lesion in Marfan syndrome: the ultrastructure of cystic medial degeneration.

Areas of medial alteration (Erdheim cystic medionecrosis) in an aortic root aneurysm surgically removed from a patient with Marfan syndrome were studied with an electron microscope. The single striking morphologic abnormality was the disorganized, haphazard architecture of the media in these areas. This lesion is interpreted as being an abortive reparative response to hemodynamic stress in a condition with a molecular defect in the structural proteins of connective tissue.

Adult↗