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Biomedical subjects

M Sansone

Publications and source records attributed to M Sansone.

At least 73 records · Page 4Linked to original sources
PubMed1980

Influence of benzodiazepine tranquilizers on amphetamine-induced locomotor stimulation in mice.

Four benzodiazepine tranquilizers have been tested, alone or in combination with amphetamine, on spontaneous locomotor activity of C57BL/6 mice. Amphetamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. The results indicate that benzodiazepine derivatives may be somewhat differentiated on the basis of their interactions with amphetamine.

Amphetamine↗
PubMed1980

Effects of chlordiazepoxide-morphine combinations on spontaneous locomotor activity in three inbred strains of mice.

Spontaneous locomotor activity has been studied, in three strains of mice, following the administration of morphine and chlordiazepoxide, given alone or in combination. The results demonstrate that chlordiazepoxide enhances the morphine-induced locomotor stimulation in C57/BL/6 and BALB/c mice and counteracts the depressant effect exerted by morphine in DBA/2 mice.

Animals↗
PubMed1979

Enhancement by chlordiazepoxide of the anticholinergic-induced locomotor stimulation in mice.

Spontaneous locomotor activity has been studied in mice treated with chlordiazepoxide, atropine, and scopolamine, given alone or in combination. Chlordiazepoxide alone increased activity for a short time, while the two anticholinergic drugs produced longer lasting stimulatory effects. Locomotor stimulation was stronger when chlordiazepoxide and anticholinergics were given in combination.

Animals↗
PubMed1978

Effects of chlordiazepoxide, amitriptyline, imipramine, and their combinations on avoidance behaviour in mice.

Chlordiazepoxide, imipramine, and amitriptyline, given alone or in combination, were tested in mice subjected to 5 daily 100-trial avoidance sessions in the shuttle-box. When the drugs were given alone, chlordiazepoxide and the lower doses of imipramine facilitated avoidance behaviour. The higher doses of the two antidepressants impaired avoidance behaviour. Mixtures of chlordiazepoxide and imipramine produced some facilitating effects, while depressant effects prevailed in the chlordiazepoxide-amitriptyline combinations.

Amitriptyline↗
PubMed1978

Effect of clonidine, amphetamine, and their combinations on the locomotor activity of CD-1 and C57BL/6 mice.

Clonidine inhibited the exploratory motor activity of C57BL/6 mice non-habituated to the testing conditions. In CD-1 mice clonidine did not depress exploratory activity but did elevate the basal locomotor activity of animals both non-habituated and habituated to testing conditions. Amphetamine increased the locomotor activity of many C57BL/6 mice and conversely inhibited the locomotion of many CD-1 mice. In both strains, amphetamine in doses up to 2 mg/kg was unable to alter effects produced by clonidine. Results suggest that the locomotor activity of C57BL/6 mice is more sensitive than that of CD-1 mice to drugs affecting the central noradrenergic system.

Amphetamine↗
PubMed1977

Improvement of shuttle-box performance of mice by combinations of benzodiazepines and morphine given during training.

Chlorodiazepoxide, diazepam and morphine, given alone or in combination, were tested in naive mice subjected to five 100-trial avoidance sessions in the shuttle-box. When given alone before each training session all three drugs improved avoidance behaviour. However, facilitation of avoidance responding was much more evident when either benzodiazepine derivative was given in combination with morphine.

Animals↗
PubMed1975

Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice.

Chlordiazepoxide and amphetamine, given separately or in combination, were tested in mice subjected to 5 100-trial avoidance sessions in the shuttle-box. Facilitation of avoidance responding was much more evident and statistically significant when the two drugs were combined. Drug mixtures produced effects which could not be obtained when the drugs were given separately.

Amphetamine↗
PubMed1975

Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone.

Melanocyte stimulating hormone (MSH) enhances melanization but inhibits proliferation of Cloudman S91 melanoma cells in culture. We have isolated variants of these cells that can grow in the presence of MSH. The conclusions we have reached from analyses of these cells are the following: (1) Basal tyrosinase activity (monophenol monooxygenase; monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1), i.e., the activity that is present in the absence of added MSH, is related through a common biochemical pathway to MSH-mediated control of growth. (2) MSH-inducible tyrosinase activity does not appear to be related to MSH control of growth. (3) The morphological changes that occur following the addition of MSH or cAMP are related to controls of growth and not to those of melanization.

Animals↗
PubMed1975

Benzodiazepines and amphetamine on avoidance behaviour in mice.

Six benzodiazepine derivatives, given alone or in combination with amphetamine, were tested in mice subjected to five 100-trial avoidance sessions in the shuttle-box. All derivatives, execpt bromazepam, showed some facilitating effects on avoidance responding when given alone. Facilitation was particularly evident following the administration of chlordiazepoxide (2.5 mg/kg), medazepam (10 mg/kg) and nitrazepam (0.25, 0.5 and 1 mg/kg). Favourable effects were obtained by combining each benzodiazepine compound with amphetamine. The levels of avoidance respinses were usually higher under benzodiazepine-amphetamine combinations than under benzodiazepines alone.

Amphetamine↗
PubMed1975

Effects of chlordiazepoxide, CNS stimulants and their combinations on avoidance behaviour in mice.

Various central stimulant drugs were tested in mice subjected to five daily 100-trial avoidance sessions in the shuttle-box. Facilitation of avoidance responding was observed following i.p. administration of metamphetamine and cocaine, but not following methlyphenidate, caffeine, pentetrazole and strychnine. Some favourable effects were obtained by combining the above stimulant drugs with cholrdiazepoxide. Advantages in the combination with chlordiazepoxide were particularly evident in the case of methamphetamine.

Animals↗