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Biomedical subjects

M Sano

Publications and source records attributed to M Sano.

At least 649 records · Page 36Linked to original sources
PubMed1983

Detergent-extraction of a regulatory subunit of brain adenylate cyclase and its sensitivity to calmodulin and forskolin.

The increase in activity of brain adenylate cyclase caused by nonionic detergent might be associated with the response of this enzyme to calcium and calmodulin. The loss of fluoride and guanyl 5'-yl imidodiphosphate stimulation of adenylate cyclase by the incubation of brain membranes with Lubrol PX may be regarded as a selective release of guanine nucleotide regulatory subunits. The regulatory subunit preactivated with guanyl 5'-yl imidodiphosphate was resistant to detergent extraction. The loss of the subunits from membranes did not change the sensitivity of the enzyme to calmodulin and forskolin.

Adenylyl Cyclases↗
PubMed1983

[Current status and problems of gastric cancer in the aged].

Based on our analysis of 1) gastric cancer patients surgically treated between 1972-1980 in Niigata Prefecture, 2) mortality statistics, and 3) 381 gastric cancer patients older than 70 years operated in our hospital, we concluded that 1) The number of geriatric surgical patients with gastric cancer, especially early gastric cancer, is on the increase in Niigata Prefecture. 2) The mortality from gastric cancer has decreased markedly in 70-74 year-old patients, has declined slightly in patient ranging from 75-79 years and has increased in patients over 80 years. 3) In patients between 75-79 years and 70-74 years, surgery as almost equally safe and their long-term survival rate was similar. Our results suggest that gastric cancer patients ranging between 75-79 years should be operated as radically as younger patients.

Aged↗
PubMed1982

Uptake of fat by fluorescent granular perithelial cells in cerebral cortex after administration of fat rich chow.

As reported previously, fluorescent granular perithelial cells (F.G.P.) are distributed along small blood vessels, possibly postcapillary venous vessels, in the cerebral cortex; these cells take up intraventricularly administered horseradish peroxidase efficiently. In this study it is shown that lipid substances of the blood are easily incorporated into F.G.P. and stored in their cytoplasm. The quantity of fat deposits in F.G.P. varies with the age of the animal and is very marked in old rats. The administration of elastase suppresses the fat uptake and/or facilitates the fat metabolism in F.G.P.

Aging↗
PubMed1982

[Studies on chemotherapy of parasitic helminths (IV). Effects of alkaloids from Sophora flavescens on the motility of parasitic helminths and isolated host tissues (author's transl)].

Effects of N-methylcytisine (N-MC) and matrine (Mat), alkaloids from Sophora flavescens on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) The motility of Angiostrongylus cantonensis was affected spastically by N-MC (1.2 X 10(-6) approximately 1.2 X 10(-4) M), but paralytically by Mat (10(-5) approximately 10(-4) M). 2) The motility of Dipylidium caninum and Fasciola hepatica was affected paralytically by N-MC (1.2 X 10(-4) approximately 1.2 X 10(-3) M), but spastically by Mat (10(-4) approximately 10(-3) M). 3) Treatment with N-MC (10(-3) M) and Mat (8 X 10(-4) M) had little effect on the motility of Schistosoma japonicum. 4) Both N-MC (1.2 X 10(-5) approximately 2.4 X 10(-5) M) and Mat (10(-4) M) stimulated the twitch response induced by guanidine (2.5 X 10(-5) M) in the frog isolated rectus preparation. 5) The motility of the mouse isolated ileum preparation was affected paralytically by N-MC (1.2 X 10(-5) approximately 1.2 X 10(-4) M), but spastically by Mat (10(-4) approximately 10(-3) M). Thus, N-MC and Mat acted antagonistically on all the preparations with the exception of the frog rectus preparation. From the results on interactions between these alkaloids and known neuropharmacological agents, it is suggested that the effects of both alkaloids are elicited through a neuropharmacological mechanism in parasitic helminths and host tissues.

Alkaloids↗
PubMed1982

[Studies on chemotherapy of parasitic helminths (III). Effects of tuberostemonine from Stemona japonica on the motility of parasitic helminths and isolated host tissues (author's transl)].

Effects of tuberostemonine (TS), an alkaloid from Stemona japonica, on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. 1) TS (6.7 X 10(-6) approximately 2 X 10(-5) M) paralyzed the motility of Angiostrongylus cantonensis. 2) TS (6.7 X 10(-5) M) showed contractive effects on the motility of Dipylidium caninum and Fasciola hepatica. 3) Treatment with TS (6.7 X 10(-5) approximately 4.8 X 10(-4) M) had little effect on the motility of Schistosoma japonicum. 4) TS (6.7 X 10(-5) M) paralyzed the motility of the mouse isolated ileum preparation. 5) TS (6.7 X 10(-7) 6.7 X 10(-6) M) stimulated the twitch response induced by guanidine (2.5 X 10(-3) M) in the frog isolated rectus preparation. 6) Eserine and TS acted antagonistically on all preparations with the the exception of S. japonicum. 7) TS and strychnine were antagonistic in isolated host tissues, whereas these compounds acted similarly on parasitic helminths. Thus, it is suggested that some of the experiential effects of the crude extracts of Stemona such as the anthelmintic effects are caused through the action of TS on parasitic helminths and host tissues.

Alkaloids↗