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Biomedical subjects

M Sano

Publications and source records attributed to M Sano.

At least 559 records · Page 31Linked to original sources
PubMed1986

[Adenoid cystic carcinoma of the esophagus].

A 56-year-old man was admitted with the complaint of dysphagia. X-ray studies and endoscopy revealed a protruding tumor at the middle third of esophagus. Under the diagnosis of esophageal cancer, subtotal esophagectomy was performed. A Borrmann type I like tumor measuring 6.7 X 3.8 X 2.2 cm was identified on the resected specimen. The surface of the tumor was irregular, nodular and covered with thin compressed esophageal mucosa. The histology of the tumor was consistent with adenoid cystic carcinoma. Incidentally, small foci of invasive squamous cell carcinoma were found adjacent to this tumor. There was no lymph node or remote organ metastasis.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

[The function of the sympathetic nervous system determined by humoral factors in the maintenance hemodialysis patients].

Dialysis-induced hypovolemia in renal patients might accompany with decreased sympathetic tone and decreased baroreflex sensitivity. Present study was undertaken to elucidate the sympathetic nervous activity in terms of biogenic amines [plasma norepinephrine (NE), epinephrine (E) concentrations, dopamine-beta-hydroxylase activity (DBH) and plasma serotonin (5-HT) concentration] in 17 patients with chronic renal failure in whom renal hemodialysis were continuously performed. During pre-dialysis period, in these hemodialysis patients, heart rate, systolic blood pressure and plasma 5-HT were significantly elevated as compared with those on sex and age-matched controls; plasma NE and plasma DBH were not changed in these hemodialysis patients as compared with those in controls. After hemodialysis, increased plasma NE and increased DBH were observed in parallel with the significant weight loss. Mean blood pressure did not change after dialysis. Dialysis produced an increasing tendency of heart rate. Dialysis also produced a significant decrease in plasma 5-HT. Hemodialysis-induced weight loss was approximately 2 kg body weight after 5 hours dialysis; these patients were done 3 times dialysis during one week. However, hypotension and dizziness were not demonstrated under this condition. Present study revealed that long term maintenance hemodialysis produced increased sympathetic nervous system activity; the assumed explanation would be relevant to the simultaneous recovery of baroreflex sensitivity and sympathetic tone, because of the long-term continuous hemodialysis.

Adult↗
PubMed1986

[The incidence of breast cancer in Niigata Prefecture].

The number of operations, regarded as the incidence, of breast cancer in Niigata Prefecture between 1972 and 1983 was surveyed. The age-adjusted incidence rate of female breast cancer in Niigata Prefecture has increased from 12.2 (per 100,000) to 21.1 (per 100,000) during the past 10 years, although the age-adjusted mortality rate has increased only slightly, from 3.7 to 4.2 (per 100,000) during that time. The age-adjusted incidence rate also increased in the middle-aged (61%) and elderly (41%) group, incidence increased only in the elderly group (74%). It has recently been reported that the aging phenomenon of breast cancer in Japan shows a Western-type tendency. In this paper, however, this phenomenon was considered to be due merely to the increase (24%) in the population of the elderly.

Adult↗
PubMed1985

Calmodulin-dependent adenylate cyclase in rat retina and the response to dopamine.

Adenylate cyclase activity from the rat neural retina was highly stimulated with Ca2+ and calmodulin. The retinal adenylate cyclase activity was also increased by dopamine, and the activation was not changed with or without Ca2+-calmodulin in fractions from the neural retina homogenate after sucrose density gradient centrifugation. The results suggest that the two regulation systems (i.e. dopamine and Ca2+-calmodulin) of adenylate cyclase in the rat retina appear to be independent.

Adenylyl Cyclases↗
PubMed1985

Prevention of colon polyposis and carcinomas by right hemicolectomy and indomethacin in animal model.

Rats were given intrarectal instillations of N-methylnitrosourea. The experimental groups with right hemicolectomy and oral indomethacin had a significantly reduced rate of large bowel tumors. The inhibition rate of tumor development was 88% in incidence and 94% in number. This inhibition was associated with a decrease of fecal bile acid level and a shortened intestinal transit time. It was hypothesized that the change of fecal bile acid composition after surgery and the prostaglandin synthesis inhibition by indomethacin affected the promotion phase of large bowel carcinogenesis.

Animals↗
PubMed1985

Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.

Two forms of a neutral protease that catalyzed the hydrolysis of succinyl-Leu-Leu-Val-Tyr-MCA were isolated from porcine skeletal muscle cytosol by fractionation on DEAE-cellulose, hydroxyapatite and Sephadex G-100. The native enzyme had a molecular mass of above 1000 kDa. Peak A, which was eluted from hydroxyapatite at 50 mM phosphate, was activated 37-fold by the detergent, SDS, while peak B which was eluted at 150 mM phosphate, was activated only 2-fold. After dialysis against water, the B form showed restored ability to be activated by SDS (9.6-fold with 0.04% SDS). The activated peak B was extremely sensitive to divalent and monovalent cations such as Ca2+, Mg2+, Na+, K+ and NH+4 as well as protease inhibitors such as leupeptin, chymostatin and DFP. These results suggest that these proteases are generally latent in the cells and may be regulated by changes in the concentrations of cations in the cytosol. We call this new type of protease, ingensin.

Animals↗
PubMed1985

Forskolin induction of S-100 protein in glioma and hybrid cells.

The S-100 protein level in mouse neuroblastoma (N18TG-2 and NIE-115), rat glioma (C6, C6BU-1, and C6V-1), and hybrid (NG108-15, 140-3, 141-B, NBr10A, NBr20A, NCB20, and NX3IT) cells was determined with a sensitive enzyme immunoassay system that uses a rabbit antibody to bovine brain S-100 protein. S-100 protein was detected in glioma but not in neuroblastoma cells. All seven hybrid cells derived from neuroblastoma and glioma or other types of cells were found to possess a very little or undetectable S-100 protein. The induction of S-100 protein level in prestationary phase cultures of glioma C6BU-1 cells was examined by forskolin, which was a highly specific activator of adenylate cyclase of the cells and produced morphological differentiation. After incubation with 10 microM forskolin for 48 hr, the S-100 protein level increased 2-2.5-fold in C6BU-1 glioma cells whose mean control level was 60 +/- 26 ng/mg protein (+/- SD). The forskolin induction of S-100 protein in the cells was dose dependent, and the concentration of forskolin required for 50% activation of S-100 protein was about 0.6 microM. The increase by forskolin was initiated from 10-15 hr after incubation with it and was inhibited with cycloheximide and actinomycin D. In NG108-15 hybrid cells the induction of S-100 protein was also observed by forskolin as well as prostaglandin (PG) E1 plus theophylline which are known to activate adenylate cyclase of the cells. The results indicate that S-100 protein biosynthesis is genetically controlled in these clonal cells, and that S-100 protein can be regulated in a cAMP-dependent fashion in prestationary cultures.

Adenylyl Cyclases↗