Direct thiation of uridine 5'-phosphate.
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Chemical Phenomena↗
Biomedical subjects
M Saneyoshi
Publications and source records attributed to M Saneyoshi.
Alteration of codon recognition of Escherichia coli transfer RNA by modification with cyanogen bromide.
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Amino Acids↗
Synthetic nucleosides and nucleotides. I. On synthesis and properties of several thiocyanate derivatives of purines and their ribonucleosides.
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Antineoplastic Agents↗
[Chemistry of minute constituents of transfer RNA].
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Chemical Phenomena↗
Biological photochemistry. I. The correlation between the photodynamical behaviors and the chemical structures of nucleic acid-bases, nucleosides, and related compounds in the presence of methylene-blue.
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Chemical Phenomena↗
Synthetic nucleosides and nucleotides. 40. Selective inhibition of eukaryotic DNA polymerase alpha by 9-(beta-D-arabinofuranosyl)-2-(p-n-butylanilino) adenine 5'-triphosphate (BuAaraATP) and its 2'-up azido analog: synthesis and enzymatic evaluations.
Starting from 2',3',5'-tri-O-acetyl-2-iodoadenosine, 9-(beta-D-arabinofuranosyl)-2-(p-n-butylanilino)adenine and its 2'(S)-azido counterparts were synthesized in seven steps. These exhibited only moderate growth-inhibitory effects against mouse leukemic P388 cells (IC50 = 13-24 microM), although 5'-triphosphate derivatives showed strong and selective inhibitory action on calf thymus DNA polymerase alpha, but not on beta- and epsilon-polymerases from eukaryotes.
Adenine↗
Inhibition of human telomerase by L-enantiomers of natural 2'-deoxyribonucleoside 5'-triphosphates.
In order to clarify whether L-enantiomers of natural 2'-deoxyribonucleoside 5'-triphosphates (dNTPs) are recognized by human telomerase, a quantitative telomerase assay based on the 'stretch PCR' method was developed and used for kinetic analysis. Among the four L-dNTPs, L-dTTP and L-dGTP inhibited telomerase activity and the others showed slight or no inhibitory effect. Lineweaver-Burk plot analysis showed that the inhibition mode L-dGTP was competitive with dGTP.
Deoxyguanine Nucleotides↗