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Biomedical subjects

M Sandler

Publications and source records attributed to M Sandler.

At least 307 records · Page 17Linked to original sources
PubMed1972

Metabolism of isoprenaline in dog and man.

1. The metabolism of isoprenaline has been studied in man and dog following intravenous and oral or intra-duodenal administration.2. Intravenous isoprenaline was excreted largely unchanged in urine in both species. Only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.3. After oral doses in man or intraduodenal doses in dogs, plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.4. Catechol-O-methyl transferase may be less important than Uptake(2) in limiting the pharmacological action of isoprenaline.5. Pharmacological response (heart-rate increase) was related to plasma concentration of isoprenaline only after rapid intravenous injections. In dogs, following prolonged infusion or intraduodenal doses, heart rate returned to base-line values when plasma concentrations of isoprenaline were high.

Administration, Oral↗
PubMed1972

5-Hydroxyindole-secreting rectal carcinoid tumour.

A patient with a 5-hydroxyindole-secreting rectal carcinoid tumour is described, the second on record. There was no clinical evidence of carcinoid syndrome. Prostaglandin-like substances were isolated from hepatic metastases.

Adult↗