[Evaluation of the results obtained in thromboembolic vascular lesions with 2 platelet aggregation inhibitors].
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Adult↗
Biomedical subjects
M Salvetti
Publications and source records attributed to M Salvetti.
[Transcutaneous radiotherapy combined with low dose intraluminal brachytherapy in the treatment of non-operable neoplastic stenoses of the bile ducts].
Percutaneous biliary drainage is an excellent method to relieve the acute symptoms related to neoplastic stenoses of extrahepatic bile ducts. However, survival rates are low and the quality of life of these patients is poor. High dose irradiation--combined with external beams (ERT) and intraluminal brachytherapy (BRT) through percutaneous drainage--allows effective disease control and, therefore, not only higher survival rates but also a much better quality of life when drainage can be removed after bile duct stenosis resolution. March, 1990, through March, 1993, eleven patients (8 with extrahepatic cholangiocarcinomas and 3 with extrinsic tumors) were treated with combined ERT (40-60 Gy, 6-15 MV X-rays) and intraluminal BRT (6-25 Gy, 192Ir wire, LDR). In 8 patients the biliary stenosis was resolved, completely (CR) in 5 and partially (PR) in 3, as shown by posttreatment cholangiography. In 5 patients biliary drainage could be removed for an average 9 months' period; 3 of 11 patients did not respond to treatment at all (NR). Average overall survival was 14 months: 11 months for NR patients and 16.5 months for CR+PR patients. Treatment complications were acceptable: in two patients only treatment had to be discontinued, both during BRT. Two cases of high grade postirradiation stenosis were observed, both resolved with percutaneous cholangioplasthy.
Aged↗
[Use of safety catheter after removal of Kehr's tube in liver transplant patients].
The authors report on the use of a safety catheter when removing the T-tube in the patients with choledocho-choledochal biliary reconstruction after liver transplantation. After T-tube removal, bile may leak into the peritoneal cavity through the catheter insertion site in the biliary wall. Biliary peritonitis, bilomas, subhepatic collections may develop, which are difficult to treat in immunodepressed patients. The safety catheter is used to allow the external drainage of the biliary outflow, if present, and to prevent the complications due to bile collecting in the peritoneal cavity. Moreover, the catheter allows cholangiography and interventional procedures to be performed when necessary. A soft guidewire is inserted into the distal bile duct through the T-tube and pushed into the duodenum. After removing the T-tube, an 8.3-F all-purpose catheter (APD) is placed on the guidewire with the tip just outside the biliary wall. The APD is then connected to a drainage bag allowing the amount of bile eliminated daily to be checked. This maneuver was performed in 24 transplant recipients and the safety catheter correctly positioned in 22 of them (91.6%). The APD was removed 48 hours after insertion in 15 patients with no biliary leakage. In the remaining 7 patients the catheter was left in situ up to 8 days, since biliary leakage was observed (range: 50-400 ml/day). No early or late complications related to this technique were observed.
Anastomosis, Surgical↗
[The 3rd national workshop on defecography: the functional radiology of (neo) rectal ampullae (ileal reservoir, colo-anal anastomosis, continent perineal colostomy)].
A survey was made in 13 Italian centers with a questionnaire concerning the (a) indications, (b) postoperative complications, (c) functional results and (d) diagnostic imaging modalities related to the making of an ileal or colonic (neo) rectum. Ulcerative colitis (100%), familial polyposis (61.5%) and Crohn's disease (15.3%) were the most common indications for an ileal pouch; rectal cancer (7.96%), chronic inflammatory diseases (15.3%), diverticulosis, rectal prolapse, redundant colon and imperforate anus (7.6% each) were the most common indications for a colonic pouch. Postoperative complications included pelvic abscess (14%), sinus tract/dehiscence (10%) and bowel obstruction (9%). When compared with the S and W variants, the J-shaped ileoanal pouch proved superior because urgency and fecal retention rates were lower (18.4% vs. 44.4% and 23% vs. 28.6%, p < 0.01 and p < 0.05, respectively), despite slightly more frequent staining episodes (15.8% vs. 11.1%; p < 0.05). As for colonic ampullae, fecal retention and provoked evacuation were more frequent in the J pouch and after gracileplasty; urgency and incontinence in the straight colo-anal anastomosis (33.3% vs. 22.2% and 41.6% vs. 33.3%, respectively). The functional outcome was assessed by anal endosonography (available in 4/13 centers), defecography and anorectal manometry. Abnormal findings included: (a) reduced capacity, barium leakage, anal gaping, sphincter damage (urgency and incontinence); (b) barium retention, pouch dilatation, split evacuation, knobs and strictures (fecal retention).
Defecation↗