Biomedical subjects

M Salinas-Carmona

Publications and source records attributed to M Salinas-Carmona.

2 recordsLinked to original sources

PubMed1983

T lymphocyte subsets in uveitis.

We evaluated the peripheral T-cell subsets in 32 adult patients with intraocular inflammatory disease and 12 age-matched normal controls by means of the OKT series of monoclonal antibodies in conjunction with the laser cytofluorograph, which quantitatively determines the fluorescence intensity of lymphocytes. We found no statistically significant difference in the ratio of OKT 4-positive (inducer) cells to OKT8-positive (suppressor) cells. However, this ratio was significantly decreased in patients with active posterior uveitis compared with controls (P less than .05). The number of OKT8-positive T lymphocytes in this group was significantly increased (P less than .01), causing a decrease in the OKT4-OKT8 ratio. In patients with positive in vitro cell-mediated responses to the retinal S-antigen, a statistically significant (P less than .05) decrease was found as well only in the patients with active disease.

Adult↗

PubMed1983

Cyclosporin A: alterations of the cellular immune response in S-antigen-induced experimental autoimmune uveitis.

We have previously shown that Cyclosporin A (CsA) is effective in preventing S-antigen (S-Ag)-induced experimental autoimmune uveitis (EAU). Lewis rats, which readily develop EAU, were studied for the alterations in cell-mediated immune functions associated with CsA therapy. Lymph nodes draining the site of S-Ag immunization were significantly smaller in the CsA-treated animals when compared to the nonprotected group (p less than 0.01), and also showed profound histologic alterations when compared to controls. In vitro responses of lymphocytes from lymph node and peripheral blood were greatly diminished in the CsA-treated animals. Sera from rats treated with CsA also were capable of inhibiting in vitro proliferative responses. These findings demonstrate that CsA-treated Lewis rats have alterations in several cell-mediated immune functions, thereby not permitting full development of the immune events that ultimately lead to uveitis.

Animals↗