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Biomedical subjects

M Saishin

Publications and source records attributed to M Saishin.

29 records · Page 2Linked to original sources
PubMed1975

Left ventricular ejection time measured by finger-tip plethysmography in healthy young Japanese. Its correction for heart rate.

Finger-tip plethysmograms were recorded photoelectrically on 200 young males and females each. The relation between the left ventricular ejection time (ET) and the preceding heart rate (HR) and a method for correcting ET for the heart rate were studied. The values calculated by the formula ET/S-S or ET/square root S-S varied with the HR, so these formulae cannot be used for correcting the ET for HR. Thus from the relationship between ET and HR, a formula for converting the measured ET to the ET at an HR OF 70, I.E. ETc, was deduced. ETc equals ET + HR - 70. This formula can be used for both sexes of Japanese juveniles and the values obtained by it can be directly compared, irrespective of the HR.

Adolescent↗
PubMedDate not supplied

Design concept and construction of a hybrid lamellar keratoprosthesis.

A novel hybrid lamellar keratoprosthesis composed of epithelium and stroma was developed. Artificial extracellular matrices were constituted of photocrosslinkable copolymers of N,N-dimethylacrylamide and 2-(7-coumaroxy)ethyl methacrylate; a copolymer with a high content of coumarin (A) was used as a basement membrane (BM) for the epithelium, and a copolymer with a low content (B) was used for entrapment of keratocytes. The lamellar keratoprosthesis was constructed as follows: First, a viscous buffer solution containing water-soluble copolymer (B), collagen, and keratocytes derived from rabbit was prepared. Then, a cast film of copolymer (A) was tightly placed onto the mixed solution. Ultraviolet light irradiation leading to intermolecular dimerization of coumarin groups resulted in the formation of a transparent keratocyte-entrapped hydrogel that was layered with an artificial BM. Epithelial cells were seeded on the BM. Further culturing produced the lamellar keratoprosthesis, within which both kinds of cells proliferated well. The preliminary study on two week implantation of the lamellar keratoprosthesis in rabbits provided quite promising results; adverse tissue reactions, such as corneal opacity and neovascularization, were not observed.

Animals↗