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Biomedical subjects

M Said

Publications and source records attributed to M Said.

At least 37 records · Page 2Linked to original sources
PubMed1983

Recent results of the German Thorotrast study--dose relevant physical and biological properties of Thorotrast equivalent colloids.

As a prerequisite for quantifying the non-radiation effect of Thorotrast, nonradioactive and radioactive aquasols with identical physicochemical properties and with biophysical behavior comparable to that of Thorotrast were developed and produced for a second long-term animal experiment. Comparative investigations with hafnium and zirconium (zirconotrast) dioxide aquasols showed the latter to be most appropriate considering the size of both the dispersoids and the aggregates in the liver tissue. The average particle diameters of ThO2, ZrO2 and HfO2 proved to be values of 9.3 nm, 15 nm and 45 nm, respectively. The size of the aggregates shows a slight dependence on the applied amount but no dependence on the duration of body burden of the colloid. The aggregate diameters in the 600 microliters group turned out to be 9.6 microns, 14.4 microns and 5.3 microns, respectively. Radioactive zirconotrast was prepared by radiochemical incorporation of 230Th and 228Th at dose rates which produce accumulated doses in the liver of rats equivalent to those of commercial 230Th enriched Thorotrast after 1.5 yr. Five different colloids were prepared with alpha-energy emission rates increased by factors of 1, 2.5, 5, 10 and 25 compared to Thorotrast and then injected into rats.

Animals↗
PubMed1982

[Varying utilization of glucose and sorbitol in drug-induced hypercortical metabolism].

Utilisation of glucose and sorbitol in medically induced hypercorticalic states was investigated by means of the steroid-glucose-tolerance-test (SGTT) in 9 children, aged 6-16 years suffering from obesity and prediabetes. Prednisolone (1 mg/kg up to 20 mg) was applied 9 and 3 h prior to the loading tests. Blood samples were taken 0, 2, 5, 30, 60, 90, 120, 150 and 180 min after the onset of the loading tests. During the intravenous infusion of glucose (initial 0,33 g/kg followed by 12 mg/kg/min through 2 h) the mean blood glucose values increased from 103 +/- 15,5 to 388 +/- 96,6 mg/100 ml. Decrease of glycemia began delayed after 90 min, and did not approach the 180 min normal values in 3 of 9 patients. In analogous sorbitol-loading tests performed 2 to 6 days later blood glucose rose from 93 +/- 16,6 mg/100 ml to 129 +/- 28,7 mg/100 ml only. There was a significantly higher blood glucose level on SGTT as compared to steroid-sorbitol loading through the whole test period. Renal losses of glucose after SGTT as well as sorbitol losses after steroid-sorbitol loading amounted to approximately 14% of the doses supplied. The resulting data point to the advantages of combined glucose and non-glucose carbohydrate application for parenteral nutrition in medically induced and postoperative hypercorticalic states of metabolism.

Adolescent↗
PubMed1979

The treatment of tuberculous meningitis in children with a combination of isoniazid, rifampicin and streptomycin--preliminary report.

Twenty two children with tuberculous meningitis were treated with isoniazid, streptomycin and rifampicin and 19 were treated with isoniazid, PAS and streptomycin for at least 18 months. Both groups received corticosteroids at the beginning of treatment. The 2 groups were compared for clinical and neurological improvement, rate of recovery, the presence of neurological sequelae and for mortality. The drug toxicity of both regimens was also compared. The rate of recovery in the first 2 months of treatment was slightly more rapid in group I than in group II and neurological sequelae were less frequent in group I than in group II, but the differences between the groups were not statistically significant. There was very little difference in the death rate in both groups. A high incidence of jaundice was found amongst the children who received rifampicin.

Child↗
PubMed1979

Cell mediated immune (CMI) responsiveness to soluble egg antigen (SEA) and its relation to the occurrence of schistosomal hepatosplenic disease in patients with schistosomiasis mansoni.

The delayed intradermal test and migration inhibition tests were used to assess the delayed hypersensitivity in patients with BHF and simple intestinal bilharziasis using SEA. All bilharzial patients gave a positive intradermal test. The specificity of the intradermal test using SEA is demonstrated clearly by the negative response in all control groups.

Adult↗
PubMed1978

Intravenous fat tolerance in hepatic schistosomiasis.

The elimination rate of lipid after a single intravenous dose of an artificial fat emulsion was studied in 13 schistosomal patients and 13 controls. A strikingly significant lower level was found in the mean incremental values of TG ten minutes after injection in the schistosomal patients than the controls. The shape of the curve up to 120 minutes after injection was of zero order in the controls but exponential in the schistosomal patients. The possible factors responsible for these differences are discussed.

Adolescent↗
PubMed1978

Thyroid function in hepatic schistosomiasis.

Serum thyroxine (T4), serum tri-iodothyronine (T3-uptake) and the free thyroxine index in 17 men suffering from hepatosplenic schistosomiasis did not differ significantly from those of ten healthy male controls. There was no correlation between these values and serum protein levels or liver function tests.

Adolescent↗
PubMed1976

Single dose therapy of trichomoniasis with tinidazole.

Tinidazole was used in a single dose of 2.1G for 52 patients found to have Trichomonas Vaginalis infection. Husbands of 28 patients were also treated. The cure rate in 35 cases followed for 4 weeks or more was 100%. The drug was well tolerated.

Adolescent↗