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Biomedical subjects

M Saegusa

Publications and source records attributed to M Saegusa.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Intravesical chemotherapy with interferon in superficial bladder tumors].

Interferon (IFN) was used in the treatment of superficial bladder tumors. Interferon (IFN-beta, IFN-gamma) was instilled into the bladder at dosages ranging from 16 billion to 36 billion U IFN per 30 ml physiological saline. The IFN was instilled into the bladder once a day or twice a day for 10 to 20 days. In this trial, ten patients with superficial bladder tumors were treated at Okayama City Hospital, and of these, 1 CR, 3 PR, 2 MR and 4 NC were obtained. There were no signs of either irritable bladder or general side effects. IFN (especially IFN-beta) is considered a useful drug for superficial bladder tumors in intravesical chemotherapy.

Administration, Intravesical↗
PubMed1987

[A new anti-cancer agent, bestrabucil (KM 2210): I. Concentration in the serum and tissue in urogenital tumors].

Serum and tissue concentrations of bestrabucil (KM 2210), a combined agent of 17-estradiol and Chlorambucil, were examined in patients with urogenital cancers including those of the kidney, bladder, prostate and testis. We administered orally 100mg (50 mg X 2/day of bestrabucil for 3 days), and determined its plasma levels and metabolites. A maximum drug concentration, i.e., 9.25 ng/ml, was noted 3 hours after administration; a constant plasma level of 5 ng/ml was maintained and the concentration of free chlorambucil was low. After single or consecutive oral administration of bestrabucil (100-300 mg), tumor specimens contained significantly large amounts of bestrabucil in comparison with adjacent normal tissue. Selective accumulation of the active component in tumor tissue suggests the clinical usefulness of bestrabucil.

Administration, Oral↗
PubMed1978

The development of a fibre optic catheter tip pressure transducer.

There has been much discussion on the distortion of intracardiac pressure waveforms measured by catheter methods. Tip transducers, which can eliminate this waveform distortion, have several problems. There are manufacturing difficulties with the mechano-electric transducing element. The devices also do not remain stable over variations in temperature and with long term clinical use. Safety problems may also be experienced due to the direct connection between external electronic devices and the heart. In order to overcome these difficulties, the application of fibre optics to the measurement of intracardiac pressure has been proposed. In this paper, the design, construction, and evaluation of a side-hole optic catheter, intended for intracardiac pressure measurement, is described.

Animals↗