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Biomedical subjects

M Sadeh

Publications and source records attributed to M Sadeh.

At least 91 records · Page 5Linked to original sources
PubMed1987

Familial bilateral paralysis of diaphragm. Adult onset.

At age 50 two homozygote twin brothers developed bilateral paralysis of the diaphragm. No infectious, metabolic, degenerative or proliferative disorders of the neuromuscular system and no thoracic diseases which could explain this lesion were detected during four years of follow-up. It appears thus to be an isolated lesion of genetic origin. To the best of our knowledge, no similar cases have been reported in literature.

Diaphragm↗
PubMed1986

Occurrence of alkaline phosphatase-positive fibers in experimental muscle disorders.

The alkaline phosphatase (AP) reaction was carried out on muscle sections from a large series of rats under various experimental neuromuscular disorders. Only denervated and non-innervated muscle fibers stained positively with the AP reaction. In other conditions including degenerating, regenerating, tenotomized and immature muscles the AP reaction was negative. This suggests that the presence of AP-positive fibers in human neuromuscular disorders reflects a concomitant denervation process.

Alkaline Phosphatase↗
PubMed1985

Altered rat skeletal muscle carnitine with age and after denervation.

We investigated the effect of denervation on the concentration of total free, and acyl carnitine in the soleus (S), extensor digitorum longus (EDL), and anterior tibial (AT) muscles of the rat. Soon after denervation there was a marked decrease in total carnitine in all three muscles. Acyl carnitine levels decreased concomitantly with changes in total carnitine. In control but not in denervated muscle, the carnitine concentration was age-dependent during the period of rapid growth of the animals. The highest carnitine concentration was observed at 14 weeks of age. The results of this study suggest that normal innervation significantly influences carnitine-mediated lipid metabolism in skeletal muscle.

Age Factors↗
PubMed1985

Chronic myopathy induced by repeated bupivacaine injections.

The effect of recurrent cycles of muscle fiber degeneration-regeneration was studied by repeated bupivacaine injections into the rat anterior tibial muscle. Injections of 0.6 ml of 0.75% bupivacaine were performed weekly for 6 months. The rats were allowed to recover for another 2 months and then killed. Histological and histochemical stains showed striking changes, including marked variability in fiber size, numerous internal nuclei, extensive fiber splitting and many whorled fibers. Combined staining for end-plate cholinesterase and terminal axons showed a markedly enlarged zone of terminal innervation. These findings suggest that the observed morphological changes usually attributed to a primary myopathic process may instead be the manifestations of impaired and incomplete regeneration occurring after cycles of degeneration-regeneration.

Adenosine Triphosphatases↗
PubMed1985

Minimal time interval in auditory temporal resolution.

Human auditory temporal resolution was measured. Normal-hearing adults in 3 age groups (I: mn age: 24 yrs, N:55; II: mn age: 44.5 yrs, N: 25; III: mn age: 66.4 yrs, N:18) were required to indicate in which of 2 successive noise bursts of relatively low frequency (concentrated from .1-.5 kc/s) a brief temporal gap was inserted. The noise was created by passing a 100-c/s square wave through an electronic switch with virtually instantaneous rise-fall time and through a clinical audiometer to the associated earphone. The level was set at about the loudness of each S's HTL at .25 kc/s. The minimum detectable time interval (delta t) varied lawfully and significantly (p less than .001) with burst duration and with age. For all ages delta t was approximately equal to 3 msec when the burst duration was longest (85 msec), but at the shortest duration (10 msec) it rose to 17.6, 22.2, and 29.9 msec for Grps I-III, respectively. The interaction between age and duration was also significant (p less than .001). It was suggested that establishment of delta t by this or a similar procedure could offer an important parameter for evaluation of auditory function.

Adult↗
PubMed1985

Changes in end-plate cholinesterase and axons during muscle degeneration and regeneration.

Injection of bupivacaine into the rat anterior tibial muscle produced rapid necrosis with disintegration of muscle fibres and phagocytic infiltration within two days. Regenerating myotubes appeared four days after injection, and muscle structure was restored seven days after injection. One day after injection, axons and end-plate cholinesterase appeared normal in spite of the underlying muscle fibre necrosis. Intensity of cholinesterase staining was gradually reduced through the second and third day but axons remained intact. On the fourth day, newly formed end-plates delineated by cholinesterase stain were seen on myotubes. Some were innervated by thin regenerating axons. Axonal outgrowth appeared to compensate for occasional neuronal degeneration and for the greater number of end-plates on myotubes. In some areas, not all end-plates were innervated by the fourth day but were by the fifth day. On the sixth and seventh day after myotube maturation, a process of degeneration of superfluous end-plates and axons occurred, reducing their number to the number of muscle fibres. Fourteen and 28 days after injection, the innervation pattern was normal except for a slight increase in terminal innervation band width. These results indicate that injection of bupivacaine does not directly affect intramuscular nerves and that the changes observed in this experimental model are the consequence of muscle fibre degeneration and regeneration.

Animals↗
PubMed1984

Alterations in creatine kinase, ornithine decarboxylase, and transglutaminase during muscle regeneration.

Creatine kinase (CK), transglutaminase (TGase) and ornithine decarboxylase (ODC), enzymes implicated in the regulation of growth processes, were studied during muscle regeneration subsequent to the injection of bupivacaine into rat tibialis anterior. Within 2 days, the percent BB isozyme of CK detected in the muscle was elevated 70-fold coincident with a marked decrease in total CK activity. The MB isozyme also increased and was 15-fold of control at 4-5 days postinjection. TGase activity was increased significantly to greater than 2-fold of control within 2 days of injection and significantly decreased at days 3 through 7 compared to controls. ODC activity was elevated significantly to 2- to 3-fold of control from 2-7 days after injection. These results suggest an early alteration in the expression of a coordinated battery of genes in this model of muscle degeneration-regeneration. The increased expression of MB and BB isozymes of CK in various human neuromuscular diseases may be a manifestation of an ongoing process of degeneration-regeneration.

Acyltransferases↗
PubMed1984

Changes in muscle carnitine during regeneration.

Carnitine in rat skeletal muscle was measured before, during, and after muscle regeneration. Early regenerating tibialis anterior muscle consequent to bupivacaine injection was found to have smaller amounts of total, free, and acyl carnitine per milligram wet weight, but returned toward normal values as muscle regeneration was completed. Accumulation of DL-[3H]carnitine per milligram wet weight in regenerating muscle was less than one-half that of control muscle at day 4 (P less than 0.005), but was not significantly different from the control value at day 7. Our results are consistent with the hypothesis that the reported decrease in muscle carnitine content in several different human neuromuscular diseases is in part a manifestation of muscle fiber regeneration.

Animals↗
PubMed1984

Increased activities of MB and BB isozymes of creatine kinase in denervated neonatal and adult rat muscle.

Creatine kinase (CK) activity and isozyme patterns were assessed in newborn and adult rat anterior tibial muscle in response to denervation. Total CK activity was low in the control neonatal muscle, gradually increasing to the adult level within 1 month. Denervation prevented this normal increase, and, therefore, CK activity was reduced to 25% of control at 2 months. In the denervated adult muscle, total CK activity decreased to 50% of control within 3 weeks and remained at that level. Denervation of neonatal muscle resulted in a greater conservation of MB isozyme compared with controls. The alteration in BB isozyme expression was even more dramatic with a 33-fold difference expressed at 2 months in terms of percent total CK in denervated vs. control muscle. In denervated adult muscle, MB and BB isozyme activities increased gradually, attaining levels 3-fold and 13-fold, respectively, above control muscle at the end of the experimental period.

Aging↗
PubMed1983

Postictal blindness in adults.

Cortical blindness following grand mal seizures occurred in five adult patients. The causes of seizures included idiopathic epilepsy, vascular accident, brain cyst, acute encephalitis and chronic encephalitis. Blindness was permanent in one patients, but the others recovered within several days. Since most of the patients were either unaware of or denied their blindness, it is possible that this event often goes unrecognised. Cerebral hypoxia is considered the most likely mechanism.

Adult↗
PubMed1982

Basal encephalocele associated with suprasellar epidermoid cyst.

A 27-year-old woman suffered from multiple congenital defects, including transsphenoidal encephalocele. Recent progressive visual loss was at first attributed to this encephalocele, but was later proved to be caused by a suprasellar epidermoid cyst. Its removal was followed by improvement of vision. To the best of our knowledge, the association of basal encephalocele and epidermoid cyst has not been previously described.

Abnormalities, Multiple↗
PubMed1982

Periodic ataxia: an unusual non-familial variation with paroxysmal EEG features.

A 19-year-old youth suffered from periodic attacks of ataxia and dysarthria. Abnormally high IgG and IgA levels were found in the CSF. The length of the episodes of ataxia, absence of family history and the presence of generalised paroxysmal features in the EEG constitute a combination which is not believed to have been recorded previously. Carbamazepine was ineffective but temporary clinical and electroencephalographic improvement followed the administration of ACTH. Acetazolamide therapy has resulted in prolonged remissions from attacks.

Adult↗
PubMed1982

Multifocal neuropathy and vocal cord paralysis in relapsing fever.

A 19-year-old soldier developed multifocal neuropathy following an infection with tick-borne Borrelia. He suffered from involvement of the right accessory nerve, the right brachial plexus and the left recurrent laryngeal nerve. As was expected, all these complications were reversible. In contrast to louse-borne relapsing fever, neurological manifestations in the tick-borne variants are not common. To the best of our knowledge, vocal cord paralysis has never been described before.

Adult↗