Biomedical subjects

M Sadanaga

Publications and source records attributed to M Sadanaga.

13 recordsLinked to original sources

PubMed1992

Skin pretreatments for shortening onset of dermal patch anesthesia with 3% GA MHPh 2Na-10% lidocaine gel mixture.

Three types of skin pretreatments (stripping with adhesive tape, scrubbing with Skin-Pure jelly, and cleaning with benzine) were studied in 21 volunteers to determine whether the pretreatments could shorten the application period of transdermal 3% GA MHPh 2Na-10% lidocaine gel. Before application of the gel, each subject received skin pretreatment on the volar surface of one forearm. Then, the lidocaine gel soaked in a round sponge was applied on both the pretreated area of the forearm and the unpretreated contrast area of the other forearm. A pain score was obtained from each subject at 30, 45, 60, and 75 min after placement of the dermal patch by noting the number of painful pinpricks of five delivered. The mean pain scores on the pretreated side were significantly lower at 30, 45, and 60 min in the stripping study group and at 45 and 60 min in the cleaning study group, compared with the corresponding scores on the unpretreated side (P less than 0.05). Skin pretreatments, such as stripping and cleaning, are useful for shortening the onset of the dermal patch anesthesia.

Administration, Cutaneous↗

PubMed1992

[Studies of emergency cardiopulmonary bypass (ECPB) for cardiopulmonary-cerebral resuscitation; (1) Introduction of a portable-percutaneous ECPB system].

The authors have developed an ECPB system, which can be applied quickly, safely and easily under an emergency condition requiring cardiac massage and artificial ventilation. Fundamentally, the ECPB system consists of 3 parts; a portable ECPB apparatus, a pair of percutaneous cannulae and a short circuit connecting an oxygenator with the cannulae. The ECPB apparatus is assembled with commercially available components (i.e., a centrifugal pump, a battery pack, a temperature controller, a compact membrane oxygenator with a heat exchanger, etc) and they are placed on a mobile cart. The circuit is primed with 300 ml of lactated Ringer solution. The priming can be done within 15 minutes via a reservoir. It is also possible to keep the primed circuit to be ready for emergency use at least for a week. The cannulae are placed intravascularly through the femoral artery and vein by using the Seldinger's percutaneous method. In an emergency situation, the arterial and venous cannulations are carried out separately on the both inguinal regions to save time. The tip of the venous cannula is adjusted to be placed near the right atrium under fluoroscopy. Initiation of ECPB via the femoro-femoral V-A cannulae assures instant and stable supply of oxygenated blood to all of the vital organs. At the present time, nothing is more important than a quick supply of oxygenated blood to the brain to ameliorate the post-ischemic brain damage.

Cardiopulmonary Bypass↗

PubMed1989

To-and-fro veno-venous extracorporeal lung assist for newborns with severe respiratory distress.

A veno-venous to-and-fro bypass method through a single blood access for extracorporeal lung assist with an artificial membrane lung is introduced. A premature newborn with severe respiratory distress was treated with this method. A 12 Fr. single lumen catheter with a spiral-embedded thin-wall, 0.25 mm in wall thickness, was placed in the right internal jugular vein. Venous blood was withdrawn and oxygenated blood returned alternately through the same catheter. Thus both carotid arteries and other large veins were kept intact. During the extracorporeal bypass, the patient was put on intermittent mandatory ventilation of 2 times/min for lung rest providing adequate arterial blood gases, and he survived.

Cardiopulmonary Bypass↗

PubMed1989

Clinical evaluation of vidian neurectomy for nasal allergy.

For the clinical evaluation of vidian neurectomy, questionnaires were sent to 250 cases operated on from 1971 to 1982, with answers obtained from 171. For sneezing, 56.8% of cases were evaluated markedly effective, 36.7% effective, 4.3% unchanged, and 2.2% aggravated. For rhinorrhea, markedly effective was 54.7%; effective, 39.4%; unchanged, 3.7%; aggravated, 2.2%. For nasal obstruction, markedly effective was 67.5%; effective, 27.4%; unchanged, 5.1%; and aggravated, 0%. On the other hand, 20% of cases complained of relapse of nasal allergic symptoms. Concerning the side effects, 28.7% of cases complained of cheek, upper lip, or palate numbness. Decrease of lacrimation was noted in 9.4% of cases. Several kinds of disturbances in the eye movement were observed in 4% of cases. Among them, 16 cases showed complete recovery within 24 h. In 3 cases, abducens paralysis continued for several months. Postoperative arterial bleeding occurred in one case. My recent strategy for the treatment of allergic rhinitis is conservative treatment at first, secondary nasal surgery such as septoplasty or turbinotomy, and at last vidian neurectomy if the patient agrees to be operated on after understanding the side effects.

Abducens Nerve↗

PubMed1988